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New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies


New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies
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New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies


New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies
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Author : Alessandra Stasi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-03

New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies written by Alessandra Stasi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-03 with Medical categories.




Community Series In New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies Volume Ii


Community Series In New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies Volume Ii
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Author : Alessandra Stasi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-17

Community Series In New Insights In Sepsis Pathogenesis And Renal Dysfunction Immune Mechanisms And Novel Management Strategies Volume Ii written by Alessandra Stasi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-17 with Medical categories.


This Research Topic is the second volume of the “New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies” Community Series. Please see the first volume here. Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization. Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.



Immunity And Inflammatory Responses In Kidney Disease From Mechanisms To Novel Therapeutic Strategies


Immunity And Inflammatory Responses In Kidney Disease From Mechanisms To Novel Therapeutic Strategies
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Author : Wei Jing Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-30

Immunity And Inflammatory Responses In Kidney Disease From Mechanisms To Novel Therapeutic Strategies written by Wei Jing Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-30 with Medical categories.


Kidney disease is a leading cause of death worldwide and is increasingly recognized as a global health problem. The kidneys are a frequent target of systemic immune and autoimmune disorders, including systemic autoimmunity and vasculitis, immune complex-related serum sickness, and complement disorders. The complex regulation between the immune system and inflammation plays a key role in the progression of kidney disease, especially in immune-related nephropathy. Cytokines released by monocytes/macrophages, including IL-17, INF-γ, TNF, and IL-6, exacerbate renal dysfunction and injury. M1 pro-inflammatory cells help to clear infections but can also promote renal injury and lead to renal fibrosis. Loss of immune homeostasis can exacerbate the adverse effects of inflammation on the kidney and lead to loss of renal function. Therefore, further understanding of immune dysregulation and inflammatory responses has the potential to develop innovative, paradigm-shifting strategies for the treatment of kidney disease. The development of novel computational tools and genomic data analysis are accelerating our understanding of the crosstalk of immunity and inflammation in kidney disease. The aim of this Research Topic is to provide a forum to explore potential and effective therapeutic targets by focusing on the role of regulatory mechanisms of immunity and inflammation in renal disease. We aim to elucidate the possible biological mechanisms of immunity and inflammation in the pathogenesis of kidney disease. We welcome submissions of Original Research and Review articles, including but not limited to the following: (1) The role of immune regulation of inflammation in immune-related nephropathy. (2) Mechanisms of immune and inflammatory interactions in hypertensive nephropathy. (3) Emerging novel cytokines and immune markers in the diagnosis and prognosis of membranous nephropathy. (4) Pathogenetic mechanism of inflammation in chronic kidney disease. (5) Influence of chemokines and chemokine receptors on inflammation in kidney disease.



Current Perspectives In Kidney Diseases


Current Perspectives In Kidney Diseases
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Author : G. La Manna
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2017-05-23

Current Perspectives In Kidney Diseases written by G. La Manna and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-23 with Medical categories.


After years of stagnation, much has been happening in the diagnosis and treatment of kidney diseases. This book contains a comprehensive review of the main developments in AKI, CKD, hemodialysis and kidney transplantation. The section on AKI deals with the key innovations in extracorporeal technologies. The section on nephrology and CKD concentrates on mineral metabolism alterations, restenosis in hemodialytic fistulas, mycophenolate mofetil as an alternative treatment for IgA nephropathy, and the genetics and progression of autosomal dominant polycystic kidney disease. The part on hemodialysis includes contributions on expanded hemodialysis, potassium profiling and home hemodialysis. Chapters on the treatment of acute antibody-mediated rejection after transplantation, pathogenesis and therapy of chronic allograft injury, and non-invasive surrogate biomarkers of acute rejection round out the subjects covered. Due to the wide variety of topics included in each section, this book is not only of interest to nephrologists, but also to professionals from related fields.



Sepsis Kidney And Multiple Organ Dysfunction


Sepsis Kidney And Multiple Organ Dysfunction
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Author : C. Ronco
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2004-07

Sepsis Kidney And Multiple Organ Dysfunction written by C. Ronco and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-07 with Medical categories.


Severe sepsis is among the most common causes of death in the United States and the most common cause of death in the Intensive Care Units worldwide, and its recognition and treatment remain the most important challenges of critical care medicine. Severe sepsis and septic shock have a profound effect on kidney function and the function of other organs through complex mechanisms, which involve the immune response, multiple pro and anti-inflammatory pathways, intracellular dysfunction and hemodynamic instability. Their optimal management requires complex knowledge of general medicine, immunology, nephrology, extra-corporeal technology, fluid resuscitation and critical care endocrinology. In order to deliver optimal patient care, nephrologists and intensive care medicine specialists need to understand and be highly knowledgeable in the epidemiology of sepsis, the mechanisms of injury which determine outcome and the fundamental aspects of new insights into fluid resuscitation, acid-base physiology and glucose control. They also need to have a clear appreciation of new technical developments in the monitoring of critically ill patients and in the delivery of advanced extra-corporeal blood purification therapies. Experts from the fields of intensive care medicine, nephrology, endocrinology, acid-base physiology, extra-corporeal blood purification technology and immunology have contributed to the present book, providing a cutting edge view of developments in each field which contribute to the care of patients with severe sepsis, acute renal failure and multiple organ failure. The resulting mix of fundamental knowledge and recent developments from clinical trials and laboratory research constitute a valuable tool for all professionals involved in the care of the critically ill patient.



The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment


The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment
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Author : Luregn J. Schlapbach
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-19

The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment written by Luregn J. Schlapbach and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with categories.


We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.



Sepsis Kidney And Multiple Organ Dysfunction


Sepsis Kidney And Multiple Organ Dysfunction
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Author : Claudio Ronco
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2004-01-01

Sepsis Kidney And Multiple Organ Dysfunction written by Claudio Ronco and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-01 with Medical categories.


Severe sepsis is among the most common causes of death in the United States and the most common cause of death in the Intensive Care Units worldwide, and its recognition and treatment remain the most important challenges of critical care medicine. Severe sepsis and septic shock have a profound effect on kidney function and the function of other organs through complex mechanisms, which involve the immune response, multiple pro and anti-inflammatory pathways, intracellular dysfunction and hemodynamic instability. Their optimal management requires complex knowledge of general medicine, immunology, nephrology, extra-corporeal technology, fluid resuscitation and critical care endocrinology. In order to deliver optimal patient care, nephrologists and intensive care medicine specialists need to understand and be highly knowledgeable in the epidemiology of sepsis, the mechanisms of injury which determine outcome and the fundamental aspects of new insights into fluid resuscitation, acid-base physiology and glucose control. They also need to have a clear appreciation of new technical developments in the monitoring of critically ill patients and in the delivery of advanced extra-corporeal blood purification therapies.Experts from the fields of intensive care medicine, nephrology, endocrinology, acid-base physiology, extra-corporeal blood purification technology and immunology have contributed to the present book, providing a cutting edge view of developments in each field which contribute to the care of patients with severe sepsis, acute renal failure and multiple organ failure. The resulting mix of fundamental knowledge and recent developments from clinical trials and laboratory research constitute a valuable tool for all professionals involved in the care of the critically ill patient.



Mandell Douglas And Bennett S Principles And Practice Of Infectious Diseases E Book


Mandell Douglas And Bennett S Principles And Practice Of Infectious Diseases E Book
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Author : John E. Bennett
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009-10-19

Mandell Douglas And Bennett S Principles And Practice Of Infectious Diseases E Book written by John E. Bennett and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-19 with Medical categories.


After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.



The Charnolosome As A Novel Nanothereranostic Biomarker


The Charnolosome As A Novel Nanothereranostic Biomarker
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Author : Sushil Sharma
language : en
Publisher: Elsevier
Release Date : 2024-09-30

The Charnolosome As A Novel Nanothereranostic Biomarker written by Sushil Sharma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-30 with Science categories.


The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author's original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases.The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions. - Shares the latest knowledge on the charnolosome and charnolosome-derived nano-vesicles and their significance at a cellular and molecular level - Considers the charnolosome in relation to a range of conditions, including neurodegenerative, metabolic, and multi-drug resistant systemic diseases - Presents future perspectives of the charnolosome in personalized nanotheranostics



Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases 2nd Edition


Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases 2nd Edition
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Author : Chengjin Gao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06

Characteristic Clinical Immune Phenotypes And Molecular Mechanisms Associated With Inflammatory Diseases 2nd Edition written by Chengjin Gao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Science categories.


The systemic inflammatory response is evident in inflammatory diseases, and the immune system secretes many cytokines involved, resulting in a robust immune response. For example, the pathogenesis of sepsis includes abnormal immune cell activation in the early stages as well as sepsis-related immunosuppression. During the immunosuppressive phase, CD4+ T cells, CD8+ T cells, Th17 cells, and ?d T cells are reduced while regulatory T cells increase. At the same time, T lymphocytes and neutrophils, as immune effector cells, interact with each other and play a key role in regulating the immune response to immune-inflammatory diseases. The increased release of neutrophil extracellular trap networks (NETs) by neutrophils leads to a significant upregulation of NETs-DNA-MPO, which further aggravates the septic inflammatory response and organ functional impairment. Therefore, it is important to deeply investigate the characteristic clinical immune phenotypes and molecular mechanisms associated with inflammatory diseases, and targeting therapies against them may provide new ideas for the precise treatment of diseases. The goal of this Research Topic is to provide a forum to advance research on the contribution of the fundamental mechanisms of immune system development and function, with special emphasis on the description and mechanism of clinical immunological phenotypes in different immune disorders and the definition of their molecular basis. The Research Topic had the bullet points including but not limited to the following: 1) Description of the immune phenotypes of various common acute and chronic diseases; 2) The regulatory mechanisms of different factors on the development and function of the host immune system; 3) Inflammatory immunological mechanisms, organ function, and interorgan interactions.