The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment
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The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment
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Author : Luregn J. Schlapbach
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-19
The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment written by Luregn J. Schlapbach and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with categories.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment
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Author : Luregn J. Schlapbach
language : en
Publisher:
Release Date : 2020
The Immunology Of Sepsis Understanding Host Susceptibility Pathogenesis Of Disease And Avenues For Future Treatment written by Luregn J. Schlapbach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Non Coding Rna In Immunotherapies And Immune Regulation
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Author : Bertrand Kaeffer
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-02
Non Coding Rna In Immunotherapies And Immune Regulation written by Bertrand Kaeffer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Medical categories.
Understanding Crohn S Disease Immunity Genes And Microbes
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Author : Amélia Sarmento
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-11
Understanding Crohn S Disease Immunity Genes And Microbes written by Amélia Sarmento and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-11 with categories.
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology.
Handbook Of Sepsis
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Author : W. Joost Wiersinga
language : en
Publisher: Springer
Release Date : 2018-04-13
Handbook Of Sepsis written by W. Joost Wiersinga and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-13 with Medical categories.
This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Buruli Ulcer
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Author : Gerd Pluschke
language : en
Publisher: Springer
Release Date : 2019-04-29
Buruli Ulcer written by Gerd Pluschke and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Medical categories.
A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
Immunological Biomarkers For Tuberculosis
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Author : Christof Geldmacher
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-31
Immunological Biomarkers For Tuberculosis written by Christof Geldmacher and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Medical categories.
The Mononuclear Phagocyte System In Infectious Disease
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Author : Geanncarlo Lugo-Villarino
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-04
The Mononuclear Phagocyte System In Infectious Disease written by Geanncarlo Lugo-Villarino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with categories.
The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strategy to detect 'microbial non-self' relies on MPS to recognize conserved microbial products known as 'pathogen-associated molecular pattern' (PAMPs). PAMPs recognition represents a checkpoint in the response to pathogens and relies on conserved 'pattern recognition receptors' (PRRs). Upon PRR engagement, MPS mount a cell-autonomous attack that includes the internalization and compartmentalization of intracellular pathogens into toxic compartments that promote destruction. In parallel, MPS cells launch an inflammatory response composed of a cellular arm and soluble factors to control extracellular pathogens. In cases when innate immunity fails to eliminate the invading microbe, MPS serves as a tailor to generate adaptive immunity for pathogen eradication and generation of "memory" cells, thus ensuring enhanced protection against re-infection. Indeed, MPS cell functions comprise the capture, process, migration and delivery of antigenic information to lymphoid organs, where type-1 immunity is tailored against intracellular microbes and type-2 immunity against extracellular pathogens. However, this potent adaptive immunity is also a double-edge sword that can cause aberrant inflammatory disorders, like autoimmunity or chronic inflammation. For this reason, MPS also tailors tolerance immunity against unwanted inflammation. Successful clearance of the microbe results in its destruction and proper collection of debris, resolution of inflammation and tissue healing for which MPS is essential. Reciprocally, as part of the evolutionary process taking place in all organisms, microbes evolved strategies to circumvent the actions bestowed by MPS cells. Multiple pathogens modulate the differentiation, maturation and activation programs of the MPS, as an efficient strategy to avoid a dedicated immune response. Among the most common evasion strategies are the subversion of phagocytosis, inhibition of PRR-mediated immunity, resistance to intracellular killing by reactive oxygen and nitrogen species, restriction of phagosome maturation, modulation of cellular metabolism and nutrient acquisition, regulation of cell death and autophagy, and modulation of pro-inflammatory responses and hijacking of tolerance mechanisms, among others. The tenet of this eBook is that a better understanding of MPS in infection will yield insights for development of therapeutics to enhance antimicrobial processes or dampen detrimental inflammation for the host's benefit. We believe that contributions to this topic will serve as a platform for discussion and debate about relevant issues and themes in this field. Our aim is to bring expert junior and senior scientists to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.
Immune Imbalance In Obesity Associated Diseases
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Author : Yifu Qiu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-30
Immune Imbalance In Obesity Associated Diseases written by Yifu Qiu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-30 with Medical categories.
Repurposed Drugs As Immune Modulators To Combat Infectious Diseases
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Author : Suraj P. Parihar
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-04
Repurposed Drugs As Immune Modulators To Combat Infectious Diseases written by Suraj P. Parihar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-04 with Medical categories.