Nonlinear Dynamics Of Parkinson S Disease And The Basal Ganglia Thalamic Cortical System
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Nonlinear Dynamics Of Parkinson S Disease And The Basal Ganglia Thalamic Cortical System
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Author : Erwin B. Montgomery Jr.
language : en
Publisher: Elsevier
Release Date : 2023-06-20
Nonlinear Dynamics Of Parkinson S Disease And The Basal Ganglia Thalamic Cortical System written by Erwin B. Montgomery Jr. and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-20 with Medical categories.
Nonlinear Dynamics of Parkinson’s Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson’s disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson’s disease at the level of the lower motor neuron are also discussed. Outlines phenomenological selectivity of pallidotomy and Deep Brain Stimulation Reviews the anatomical models of pathophysiology and physiology Discusses the instrumental and analytical misrepresentations and the inferences that misrepresent the data in Nonmonotonic Nonlinear Dynamics
Nonlinear Dynamics Of Parkinson S Disease And The Basal Ganglia Thalamic Cortical System
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Author : Erwin B. Montgomery Jr.
language : en
Publisher: Elsevier
Release Date : 2023-06-30
Nonlinear Dynamics Of Parkinson S Disease And The Basal Ganglia Thalamic Cortical System written by Erwin B. Montgomery Jr. and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Medical categories.
Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-Cortical System examines current research regarding the operations of the basal ganglia-thalamic-cortical system that causes neurological disorders like Parkinson's disease. While there have been remarkable advances in the understanding of the anatomy, physiology and chemistry of these systems, there remains a significant degree of inconsistency and incompleteness between facts and advancements. This book introduces the novel concepts of nonlinear complex systems and their connection to Parkinsonism as well as hyperkinetic disorders. The actual mechanisms underlying the motor disorders of Parkinson's disease at the level of the lower motor neuron are also discussed.
Cortico Subcortical Dynamics In Parkinson S Disease
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Author : Kuei-Yuan Tseng
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-20
Cortico Subcortical Dynamics In Parkinson S Disease written by Kuei-Yuan Tseng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-20 with Medical categories.
The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.
Reproducibility In Biomedical Research
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Author : Erwin B. Montgomery Jr.
language : en
Publisher: Elsevier
Release Date : 2024-04-26
Reproducibility In Biomedical Research written by Erwin B. Montgomery Jr. and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-26 with Science categories.
Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. explores the ideas and conundrums inherent in scientific research. Reproducibility is one of the biggest challenges in biomedical research. It affects not only the ability to replicate results, but the very trust in the findings. Since published in 2019, Reproducibility of Biomedical Research: Epistemological and Statistical Problems established itself as a solid ethical reference in the area, leading to significant reflection on biomedical research. The second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters will be expanded to cover advances in the topics previously addressed. Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area. Includes four new chapters and updates across the book, covering recent developments of issues affecting reproducibility in biomedical researchCovers reproducibility of results from machine learning AI algorithmsPresents new case studies to illustrate challenges in related fieldsIncludes a companion website with interactive exercises and summary tables
Handbook Of Parkinson S Disease
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Author : Rajesh Pahwa
language : en
Publisher: CRC Press
Release Date : 2013-05-09
Handbook Of Parkinson S Disease written by Rajesh Pahwa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-09 with Medical categories.
Highly Commended, BMA Medical Book Awards 2014This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatme
Neural Modeling Of Brain And Cognitive Disorders
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Author : James A. Reggia
language : en
Publisher: World Scientific
Release Date : 1996
Neural Modeling Of Brain And Cognitive Disorders written by James A. Reggia and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
During the last few years there has been a rapidly increasing interest in neural modeling of brain and cognitive disorders. This multidisciplinary book presents a variety of such models in neurology, neuropsychology and psychiatry. A review of work in this area is given first. Computational models are then presented of memory impairment in Alzheimer's disease, functional brain reorganization following a stroke, patterns of neural activity in epilepsy, disruption of language processes in aphasia and acquired dyslexia, altered cognitive processes in schizophrenia and depression, and related disorders. This is the first book on this topic, with contributions from many of the leading researchers in this field.
Movement Control
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Author : Paul Cordo
language : en
Publisher: Cambridge University Press
Release Date : 1994-05-27
Movement Control written by Paul Cordo and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-05-27 with Medical categories.
Movement is arguably the most fundamental and important function of the nervous system. Purposive movement requires the coordination of actions within many areas of the cerebral cortex, cerebellum, basal ganglia, spinal cord, and peripheral nerves and sensory receptors, which together must control a highly complex biomechanical apparatus made up of the skeleton and muscles. Beginning at the level of biomechanics and spinal reflexes and proceeding upward to brain structures in the cerebellum, brainstem and cerebral cortex, the chapters in this book highlight the important issues in movement control. Commentaries provide a balanced treatment of the articles that have been written by experts in a variety of areas concerned with movement, including behaviour, physiology, robotics, and mathematics.
Multiscale Models Of Brain Disorders
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Author : Vassilis Cutsuridis
language : en
Publisher: Springer Nature
Release Date : 2019-10-11
Multiscale Models Of Brain Disorders written by Vassilis Cutsuridis and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Medical categories.
This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.
Neurodegenerative Diseases
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Author : Shamim I. Ahmad
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-12
Neurodegenerative Diseases written by Shamim I. Ahmad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-12 with Medical categories.
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Deep Brain Stimulation Programming
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Author : Erwin B. Montgomery, Jr.
language : en
Publisher: Oxford University Press
Release Date : 2016-04-26
Deep Brain Stimulation Programming written by Erwin B. Montgomery, Jr. and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-26 with Medical categories.
Principles of DBS electronics -- Principles of electrophysiology -- Controlling the flow of electrical charges -- DBS safety -- Nervous system responses to DBS -- DBS effects on motor control -- Pathophysiological mechanisms -- Approaches to programming -- Clinical assessments -- Approach to subthalamic nucleus -- Approach to globus pallidus internal -- Approach to thalamic DBS -- Algorithm for selecting electrode configurations and stimulation parameters -- Helpful programming hints -- Oscillator basics -- Discrete neural oscillators