Novel Anticancer Agents
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Novel Anticancer Agents
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Author : Alex A. Adjei
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Novel Anticancer Agents written by Alex A. Adjei and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field Presents drug discovery strategies Discusses regulatory issues surrounding drug development
Advances In Anticancer Agents In Medicinal Chemistry
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Author : Michelle Prudhomme
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-06-14
Advances In Anticancer Agents In Medicinal Chemistry written by Michelle Prudhomme and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-14 with Medical categories.
Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.
Novel Anticancer Drug Protocols
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Author : John K. Buolamwini
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Novel Anticancer Drug Protocols written by John K. Buolamwini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin® (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.
Anticancer Drugs
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Author : Niamh M O’Boyle
language : en
Publisher: MDPI
Release Date : 2019-10-11
Anticancer Drugs written by Niamh M O’Boyle and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-11 with Medical categories.
The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.
Heterocyclic Anticancer Agents
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Author : Bimal Krishna Banik
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2022-06-21
Heterocyclic Anticancer Agents written by Bimal Krishna Banik and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-21 with Science categories.
Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Chemistry And Pharmacology Of Anticancer Drugs
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Author : David E. Thurston
language : en
Publisher: CRC Press
Release Date : 2006-11-22
Chemistry And Pharmacology Of Anticancer Drugs written by David E. Thurston and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-22 with Medical categories.
While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells.
Anticancer Agents From Natural Products Second Edition
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2011-10-10
Anticancer Agents From Natural Products Second Edition written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Advances In Anticancer Agents In Medicinal Chemistry
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Author : Michelle Prudhomme
language : en
Publisher:
Release Date : 2013-06-14
Advances In Anticancer Agents In Medicinal Chemistry written by Michelle Prudhomme and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-14 with Medical categories.
Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series
Topics In Anti Cancer Research Volume 10
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-12-13
Topics In Anti Cancer Research Volume 10 written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-13 with Medical categories.
Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms. The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers. The topics covered in this volume are: - Peptides can play a major role in combating cancer diseases - Studying of the CLL after treatment using fractal parameter of neoplastic lymphocytes detection (ΛNLD) - Mechanistic insight of rhenium-based compounds as anti- cancer agents - Targeting cancer-specific inflammatory components in cancer therapeutics - Marine natural products as a source of novel anticancer agents: a treasure from the ocean - PDX clinical trial design in anti-cancer research
Anticancer Agents From Natural Products
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2005-06-13
Anticancer Agents From Natural Products written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-13 with Medical categories.
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen