Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 428 Skin Absorption In Vitro Method
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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 428 Skin Absorption In Vitro Method
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2004-11-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 428 Skin Absorption In Vitro Method written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-23 with categories.
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 427 Skin Absorption In Vivo Method
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2004-11-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 427 Skin Absorption In Vivo Method written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-23 with categories.
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Health Effects Test No 427 Skin Absorption In Vivo Method
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2004-11-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Health Effects Test No 427 Skin Absorption In Vivo Method written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-23 with categories.
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 435 In Vitro Membrane Barrier Test Method For Skin Corrosion
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 435 In Vitro Membrane Barrier Test Method For Skin Corrosion written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 404 Acute Dermal Irritation Corrosion
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 404 Acute Dermal Irritation Corrosion written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 431 In Vitro Skin Corrosion Reconstructed Human Epidermis Rhe Test Method
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-06-18
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 431 In Vitro Skin Corrosion Reconstructed Human Epidermis Rhe Test Method written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442d In Vitro Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Keratinocyte Activation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2024-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442d In Vitro Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Keratinocyte Activation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-25 with categories.
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with a tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This Test Guideline is proposed to address a Key Event leading to skin sensitisation, namely keratinocyte activation. This Key Event on the Adverse Outcome Pathway (AOP) leading to skin sensitisation takes place in the keratinocytes and includes inflammatory responses as well as gene expression associated with specific cell signalling pathways such as the antioxidant/electrophile response element (ARE)-dependent pathways. This Test Guideline provides three in vitro test methods addressing the same Key Event on the AOP for skin sensitisation: (i) the ARE-Nrf2 luciferase KeratinoSensTM test method, (ii) the ARE-Nrf2 luciferase LuSens test method and (iii) the Epidermal Sensitisation Assay – EpiSensA. The KeratinoSens and the Lusens are in vitro ARE-Nrf2 luciferase-based test methods and the EpiSensA is based on gene expression quantification using Reverse Transcription- quantitative PCR in reconstructed human epidermis models. The proposed test methods are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. Performance standards have been developed to enable the validation of similar test methods.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method Ter
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method Ter written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2024-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-25 with categories.
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.