Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442d In Vitro Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Keratinocyte Activation
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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442d In Vitro Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Keratinocyte Activation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2018-06-27
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442d In Vitro Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Keratinocyte Activation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-27 with categories.
This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442c In Chemico Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Covalent Binding To Proteins
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442c In Chemico Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Covalent Binding To Proteins written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This Test Guideline is proposed to address the Molecular Initiating Event leading to skin sensitisation, namely protein reactivity, by quantifying the reactivity of test chemicals towards model synthetic peptides or amino acid derivatives containing either lysine or cysteine. This Test Guideline provides three in chemico test methods addressing the same Key Event on the Adverse Outcome Pathway for Skin Sensitisation: (i) the Direct Peptide Reactivity Assay – DPRA, (ii) the Amino Acid Derivative Reactivity Assay – ADRA and (iii) the kinetic Direct Peptide Reactivity Assay – kDPRA. The DPRA and ADRA are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. In contrast, the kDPRA allows discrimination of UN GHS subcategory 1A skin sensitisers from those not categorised as subcategory 1A, i.e. subcategory 1B or no category but does not allow to distinguish sensitisers from non-sensitisers.
Oecd Guidelines For The Testing Of Chemicals Section 4 Guideline No 497 Defined Approaches On Skin Sensitisation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Guideline No 497 Defined Approaches On Skin Sensitisation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Chemical Testing Using New Approach Methodologies Nams
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Author : Amy J. Clippinger
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-16
Chemical Testing Using New Approach Methodologies Nams written by Amy J. Clippinger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Science categories.
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans
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Author : Yanzhu Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-10
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans written by Yanzhu Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-10 with Science categories.
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 442c Sensibilisation Cutan E In Chemico Essai Portant Sur L V Nement Cl Relatif L Tablissement D Une Liaison Covalente Avec Les Prot Ines Dans La Voie Toxicologique Impliqu E Dans Les Effets Ind Sirables
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2025-06-25
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 442c Sensibilisation Cutan E In Chemico Essai Portant Sur L V Nement Cl Relatif L Tablissement D Une Liaison Covalente Avec Les Prot Ines Dans La Voie Toxicologique Impliqu E Dans Les Effets Ind Sirables written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
La présente Ligne directrice fondée sur les événements clés porte sur le danger de sensibilisation cutanée pour la santé humaine faisant suite à une exposition à un produit chimique. La sensibilisation cutanée fait référence à une réponse allergique après un contact avec la peau, selon la définition du Système général harmonisé de classification et d'étiquetage des produits chimiques (SGH) des Nations Unies. La présente Ligne directrice est proposée pour l'étude de l'événement moléculaire initiateur menant à la sensibilisation cutanée, nommément la réactivité protéique, par quantification de la réactivité des produits chimiques testés vis-à-vis de modèles peptidiques ou dérivés d’acides aminés de synthèse contenant soit de la lysine, soit de la cystéine. La présente Ligne directrice décrit trois méthodes in chemico portant sur ce même événement clé : (i) l’essai de liaison directe sur la réactivité peptidique (DPRA), (ii) l’essai de réactivité à des dérivés d’acides aminés (ADRA) et (iii) l’essai cinétique de liaison directe sur la réactivité peptidique (kDPRA). Le DPRA et l’ADRA sont utilisés pour aider à distinguer les sensibilisants des non-sensibilisants cutanés. A l’inverse, le kDPRA permet de distinguer les sensibilisants cutanés de la sous-catégorie 1A du SGH de l’ONU, de ceux qui ne sont pas sous-catégorisés 1A, c’est-à-dire ceux de la sous-catégorie 1B ou non classés ; mais il ne permet pas de distinguer les sensibilisants des non-sensibilisants.
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Ligne Directrice N 497 Approches D Finies Pour La Sensibilisation Cutan E
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2025-06-25
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Ligne Directrice N 497 Approches D Finies Pour La Sensibilisation Cutan E written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
Une approche définie (AD) est un ensemble défini de sources d’information (p. ex. prédiction in silico, des données in chemico ou in vitro) utilisées en une combinaison spécifique, dont les résultats sont interprétés selon une procédure établie d’interprétation des données (modèle mathématique ou approche fondée sur des règles, par exemple). Les ADs utilisent des combinaisons de méthodes dans le but de compenser certaines des limites de chacune de ces méthodes lorsqu’elles sont appliquées seules.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2024-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442e In Vitro Skin Sensitisation In Vitro Skin Sensitisation Assays Addressing The Key Event On Activation Of Dendritic Cells On The Adverse Outcome Pathway For Skin Sensitisation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-25 with categories.
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.
Oecd Series On Testing And Assessment The Adverse Outcome Pathway For Skin Sensitisation Initiated By Covalent Binding To Proteins
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-03
Oecd Series On Testing And Assessment The Adverse Outcome Pathway For Skin Sensitisation Initiated By Covalent Binding To Proteins written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with categories.
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.