Of Microenvironments And Mammary Stem Cells

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Of Microenvironments And Mammary Stem Cells

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Author :
language : en
Publisher:
Release Date : 2007

Of Microenvironments And Mammary Stem Cells written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion and directs their critical functions. Thus guided, stem cells are able to maintain tissue homeostasis throughout the ebb and flow of metabolic and physical demands encountered over a lifetime. Indeed, a pool of stem cells maintains mammary gland structure throughout development, and responds to the physiological demands associated with pregnancy. This review discusses how stem cells were identified in both human and mouse mammary glands; each requiring different techniques that were determined by differing biological needs and ethical constraints. These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit.

Reprogramming Stem Cells Is A Microenvironmental Task

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Author :
language : en
Publisher:
Release Date : 2008

Reprogramming Stem Cells Is A Microenvironmental Task written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

That tumor cells for all practical purposes are unstable and plastic could be expected. However, the astonishing ability of the nuclei from cells of normal adult tissues to be reprogrammed - given the right embryonic context - found its final truth even for mammals in the experiments that allowed engineering Dolly (1). The landmark experiments showed that nuclei originating from cells of frozen mammary tissues were capable of being reprogrammed by the embryonic cytoplasm and its microenvironment to produce a normal sheep. The rest is history. However, whether microenvironments other than those of the embryos can also reprogram adult cells of different tissue origins still containing their cytoplasm is of obvious interest. In this issue of PNAS, the laboratory of Gilbert Smith (2) reports on how the mammary gland microenvironment can reprogram both embryonic and adult stem neuronal cells. The work is a follow-up to their previous report on testis stem cells that were reprogrammed by the mammary microenvironment (3). They demonstrated that cells isolated from the seminiferous tubules of the mature testis, mixed with normal mammary epithelial cells, contributed a sizable number of epithelial progeny to normal mammary outgrowths in transplanted mammary fat pads. However, in those experiments they were unable to distinguish which subpopulation of the testis cells contributed progeny to the mammary epithelial tree. The current work adds new, compelling, and provocative information to our understanding of stem cell plasticity. Booth et al. (2) use neuronal stem cells (NSCs) isolated from WAP-cre/R26R mice combined with unlabeled mammary epithelial cells that subsequently are implanted in cleared mammary fat pads. In this new microenvironment, the NSCs that are incorporated into the branching mammary tree make chimeric glands (Fig. 1) that remarkably can also express the milk protein [beta]-casein, progesterone receptor, and estrogen receptor [alpha]. Remarkably, the primary transplants are capable of maintaining chimerism through serial transplantation. When the chimeric glands are explanted back into NSC growth media, cells with NSC markers were present only in explants from the first transplant and not from explants in the subsequent serial transplants, suggesting that there is a window of time and an unknown but specific context for becoming NSC again.

Mammary Stem Cells

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Author : Maria del Mar Vivanco
language : en
Publisher: Humana
Release Date : 2016-10-09

Mammary Stem Cells written by Maria del Mar Vivanco and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-09 with Science categories.

The identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.

The Stem Cell Microenvironment And Its Role In Regenerative Medicine And Cancer Pathogenesis

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Author : Cristian Pablo Pennisi
language : en
Publisher: CRC Press
Release Date : 2022-09-01

The Stem Cell Microenvironment And Its Role In Regenerative Medicine And Cancer Pathogenesis written by Cristian Pablo Pennisi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Science categories.

How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation. This book discusses some of the recent advances in stem cell research that may help understanding the properties of the niche that govern stem cell fate. Technical topics discussed include:Stem cell biologyCancer stem cellsStem cell interactions with biomaterialsEngineering the stem cell microenvironmentStem cells in tissue regeneration and repairThe Disputationes Workshop series is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. This book emerges as a result of the scientific contributions presented and discussed during the fifth Disputationes Workshop held in Aalborg (Denmark) in April 2014. The stem cell microenvironment and its role in regenerative medicine and cancer pathogenesis is ideal for academic staff and master/research students in biomedical and health sciences

The Role Of Stem Cells And The Microenvironment In Breast Cancer

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Author : Noga Qimron
language : en
Publisher:
Release Date : 2010

The Role Of Stem Cells And The Microenvironment In Breast Cancer written by Noga Qimron and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Breast categories.

Human Cell Transformation

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Author : Johng S. Rhim
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-15

Human Cell Transformation written by Johng S. Rhim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-15 with Science categories.

Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes

Microenvironment Growth Control Of Mouse Mammary Epithelial Cells

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Author : Hongmei Yu
language : en
Publisher:
Release Date : 2006

Microenvironment Growth Control Of Mouse Mammary Epithelial Cells written by Hongmei Yu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Microenvironment Derived Stem Cell Plasticity

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Author : Jelena Krstic
language : en
Publisher: Frontiers Media SA
Release Date : 2017-12-21

Microenvironment Derived Stem Cell Plasticity written by Jelena Krstic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-21 with Electronic book categories.

Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.

Breast Cancer Tumor Microenvironment And Biology

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Author : Sandra Lekin
language : en
Publisher:
Release Date : 2015-01-17

Breast Cancer Tumor Microenvironment And Biology written by Sandra Lekin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-17 with Breast categories.

The causes of cancer are diversified. Cancer is the principal reason of death in the majority of countries and it results in enormous financial, societal and mental burden. Breast cancer is the most diagnosed kind of cancer and the foremost reason of deat

The Microenvironment Of Breast Cancer Stem Cells

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Author : Deepak Kanojia
language : en
Publisher:
Release Date : 2011

The Microenvironment Of Breast Cancer Stem Cells written by Deepak Kanojia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.