Oncolytic Virus
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Oncolytic Viruses
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Author : Christine E. Engeland
language : en
Publisher: Humana
Release Date : 2020-09-19
Oncolytic Viruses written by Christine E. Engeland and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-19 with Medical categories.
This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Oncolytic Viruses Genetically Engineering The Future Of Cancer Therapy
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Author : Benjamin Gesundheit
language : en
Publisher: Frontiers Media SA
Release Date : 2016-11-22
Oncolytic Viruses Genetically Engineering The Future Of Cancer Therapy written by Benjamin Gesundheit and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-22 with categories.
The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Harnessing Oncolytic Virus Mediated Antitumor Immunity
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Author : Philippe Fournier
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-02
Harnessing Oncolytic Virus Mediated Antitumor Immunity written by Philippe Fournier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-02 with Cancer categories.
Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Oncolytic Virotherapy
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Author : Ahmed Majeed Al-Shammari
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-20
Oncolytic Virotherapy written by Ahmed Majeed Al-Shammari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-20 with Science categories.
Using viruses to treat cancer is an established concept, and many viruses have shown promising anti-tumor efficacies. Oncolytic viruses are safe and well-characterized pathogens with a stable genome. The outstanding clinical results for oncolytic virotherapy deserve serious attention and consideration to make it a treatment option alongside classical cancer therapeutics. Virotherapy uses replication-competent oncolytic viruses to replicate and destroy cancer cells selectively. The transformed nature of cancer cells offers a permissive environment for some viruses’ replication and to complement viral mutations. The in situ amplification and spread within the tumor mass is the key benefit of such replication-competent viruses. Oncolytic virotherapy is divided into two main groups, according to tumor specificity: naturally oncolytic viruses to replicate in human cancer cells; and gene-modified viruses engineered to accomplish selective oncolysis.
Challenges Associated With Identifying Preclinical Animal Models For The Development Of Immune Based Therapies
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Author : Rajan P. Adhikari
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-24
Challenges Associated With Identifying Preclinical Animal Models For The Development Of Immune Based Therapies written by Rajan P. Adhikari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-24 with Medical categories.
There hasn’t been a better time to be a drug developer for immune-based therapies than the past couple of decades. We have seen an explosion in immune-based therapies for cancer, autoimmune and infectious diseases, metabolic diseases and diseases and disorders of the nervous system. The modalities of these immune-based therapies span small molecules, biologics, and gene and cell therapeutic approaches. Significant advances have been made in optimizing drug design for its specificity for the target, characterizing the mode of action in in vitro assays, and ensuring safety and manufacturability. However, an area of challenge that remains is identifying animal models for evaluating efficacy and pharmacokinetics/pharmacodynamics relationship that are predictive of drug effects in humans. Discussion on this topic is warranted as examples of failures of translation from animal models to humans provide us an opportunity to learn more about human biology.
Women In Breast Cancer 2021
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Author : Elena Provenzano
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-28
Women In Breast Cancer 2021 written by Elena Provenzano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-28 with Medical categories.
Understanding Viruses
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Author : Teri Shors
language : en
Publisher: Jones & Bartlett Publishers
Release Date : 2013
Understanding Viruses written by Teri Shors and has been published by Jones & Bartlett Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
The ideal text for undergraduate students majoring in biology, microbiology, medical technology, or pre-med, the Second Edition of Understanding Viruses provides a balanced approach to this fascinating discipline, combining the molecular, clinical, and historical aspects of virology. Updated throughout to keep pace with this fast-paced field, the text provides a strong, comprehensive introduction to human viral diseases. New material on molecular virology as well as new virus families presented coupled with chapters on viral diseases of animals; the history of clinical trials, gene therapy, and xenotranplantation; prions and viroids; plant viruses; and bacteriophages add to the scope of the text. Chapters discussing specific viral diseases weave in an epidemiological and global perspective and include treatment and prevention information. Contemporary case studies, Refresher Boxes, and Virus Files engage students in the learning process. With a wealth of student and instructor support tools, Understanding Viruses is an accessible, exciting, and engaging text for your virology course.
Exploring Oncolytic Virotherapy In Solid Tumor Treatment
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Author : Peng Qu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-26
Exploring Oncolytic Virotherapy In Solid Tumor Treatment written by Peng Qu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-26 with Medical categories.
Oncolytic virus therapy for solid tumor is an well-established concept as a promising tumor treatment strategy. Oncolytic viruses, either naturally occurring or genetically engineered, have the ability to replicate and destroy tumor cells while sparing normal cells. The lysis of tumor cells triggers potent antitumor responses and mediates tumor regression at distant sites not exposed to the virus. In 2015, the U.S. Food and Drug Administration (FDA) approved the first Oncolytic virus (OV) therapy for the treatment of melanoma lesions in the skin and lymph nodes. Despite these advancements, there are still unresolved issues regarding virus selection, dosage, and optimal administration route. The primary objective of this research topic is to monitor the latest developments in oncolytic virotherapy for solid tumors, including non-small cell lung cancer, gastric cancer, breast cancer, colorectal tumor, hepatic carcinoma, and others. The focus will be on the changes in both the immune microenvironment and immune cells induced by oncolytic virotherapy. Additionally, the research aims to discover novel oncolytic viruses or other combined therapies to enhance the safety and efficacy of oncolytic virotherapy.
Gene And Cell Therapy
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Author : Nancy Smyth Templeton
language : en
Publisher: CRC Press
Release Date : 2008-10-06
Gene And Cell Therapy written by Nancy Smyth Templeton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-06 with Science categories.
Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies. The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 2007
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Cancer categories.