Optical Coherence Tomography To Measure Effects Of Autologous Mesenchymal Stem Cell Transplant In Multiple Sclerosis Patients
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Optical Coherence Tomography To Measure Effects Of Autologous Mesenchymal Stem Cell Transplant In Multiple Sclerosis Patients
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Author : Ian Rossman
language : en
Publisher:
Release Date : 2017
Optical Coherence Tomography To Measure Effects Of Autologous Mesenchymal Stem Cell Transplant In Multiple Sclerosis Patients written by Ian Rossman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Mesenchymal stem cells categories.
Anterior visual pathway disease affects >50% of multiple sclerosis (MS) patients. Optical coherence tomography (OCT) monitors MS-related retinal degeneration. Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thinning in MS correlates with clinical and visual disability, and brain atrophy. Mesenchymal stem cells (MSC) are immunomodulatory in MS animal models, targeting inflammatory CNS injury. A recent Cleveland Clinic phase 1 trial demonstrated feasibility/tolerability of autologous MSC transplant in MS patients. My study analyzed GCL and RNFL relationships with clinical, visual, and MRI measures, before and after MSC transplant. MSC transplant affected no differences from baseline to 6 months in GCL or RNFL thickness. Linear mixed effects models predicted significant, but modest GCL thickness increases following MSC transplant. Thus, MSC neuroprotection was indirectly modeled, but not directly measured clinically or radiographically. Future MSC trials in MS should utilize OCT, a sensitive biomarker for neurodegeneration and response to experimental neuroprotective agents.
Multiple Sclerosis Therapeutics
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Author : Jeffrey A. Cohen
language : en
Publisher: Cambridge University Press
Release Date : 2011-10-20
Multiple Sclerosis Therapeutics written by Jeffrey A. Cohen and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-20 with Medical categories.
This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.
Optical Coherence Tomography In Multiple Sclerosis
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Author : Axel Petzold
language : en
Publisher: Springer
Release Date : 2015-08-28
Optical Coherence Tomography In Multiple Sclerosis written by Axel Petzold and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-28 with Medical categories.
This book gives a clinical context to optical coherence tomography (OCT) findings, while considering the differential diagnosis and providing patient management guidance. Relevant anatomical and technical aspects are discussed, followed by a pragmatic illustration of the use of OCT for the clinical spectrum of multiple sclerosis and optic neuritis, and finishing with information on monitoring ocular side effects of recently approved disease-modifying treatments in multiple sclerosis. Optical Coherence Tomography in Multiple Sclerosis: Clinical Applications is aimed at clinical neurologists working with patients suffering from MS and general neurologists who see patients with visual symptoms in their daily practice. Ophthalmologists sharing clinical responsibilities with neurologists for patients under disease-modifying treatments will also find the book of interest.
Multiple Sclerosis And Related Disorders
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Author : Robert J. Fox, MD
language : en
Publisher: Springer Publishing Company
Release Date : 2018-08-28
Multiple Sclerosis And Related Disorders written by Robert J. Fox, MD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-28 with Medical categories.
Revised and updated second edition of Multiple Sclerosis and Related Disorders: Clinical Guide to Diagnosis, Medical Management, and Rehabilitation, the only comprehensive but practical source of core information on multiple sclerosis and other demyelinating disorders. Intended as a ready reference for clinicians who provide ongoing care to MS patients, this book combines evidence-based science with experience-based guidance to present current standards and management protocols from leading MS centers. Beginning with the scientific underpinnings of MS for clinicians, the book proceeds through diagnosis, including initial symptoms, diagnostic criteria and classification, imaging, and differential diagnosis, and onto approved treatments for the various MS types and emerging therapies. Later parts of the book discuss symptom management and rehabilitation with chapters focusing on specific side effects, along with considerations for special populations, comorbidities, societal and family issues, and related autoimmune disorders that are often mistaken for MS. Throughout, chapters include lists of Key Points both for clinicians and for patients and families, and management pearls are boxed for quick reference and clinical utility. Illustrations, tables, algorithms, assessment scales, and up-to-date MRI imaging enrich the text, making this a wide-ranging clinical reference for all members of the MS care team. New to the Second Edition: Includes summary recommendations from new AAN practice guidelines for use of DMTs All chapters updated to reflect the latest literature and diagnostic criteria Five entirely new chapters added to expand coverage of treatment, rehabilitation and symptom management, and special issues related to MS Treatment section has been completely revised to better capture current approaches to disease modifying therapies, with separate chapters devoted to injection and oral therapies, infusion therapies, and treatments for progressive forms of MS Related autoimmune diseases section significantly expanded to include transverse myelitis, autoimmune encephalitis, and neurosarcoidosis
Human Amniotic Membrane Basic Science And Clinical Application
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Author : Abdul Aziz Nather
language : en
Publisher: World Scientific
Release Date : 2017-08-23
Human Amniotic Membrane Basic Science And Clinical Application written by Abdul Aziz Nather and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-23 with Science categories.
This book is a comprehensive guide for all tissue bank operators to screen, procure and process amniotic membrane for clinical application.The amnion comes close to being the ideal biological membrane or dressing — readily available, inexpensive to procure and process. Its basic science is discussed in detail — anatomy, biological and biomechanical properties.It can be procured from the placenta in normal vaginal deliveries and from Caesarean Sections. Processing is by freeze-drying or by air-drying process with sterilisation using gamma irradiation.The product has low antigenicity, has anti-microbial properties with ability to enhance epithelisation with marked relief of pain. It is useful as a dressing for wounds — flap wounds, burn wounds, injury wounds, diabetic ulcers, leprous ulcers and post-surgery wounds and post-radiation wounds. It is also used as a biological scaffold for cells in tissue engineering. Its ophthalmic applications include treatment of corneal ulcers and conjunctival tumours. Oral uses include gingiva depigmentation and periodontal regeneration.
The Fourth Industrial Revolution
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Author : Klaus Schwab
language : en
Publisher: Penguin UK
Release Date : 2017-01-03
The Fourth Industrial Revolution written by Klaus Schwab and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-03 with Business & Economics categories.
The founder and executive chairman of the World Economic Forum on how the impending technological revolution will change our lives We are on the brink of the Fourth Industrial Revolution. And this one will be unlike any other in human history. Characterized by new technologies fusing the physical, digital and biological worlds, the Fourth Industrial Revolution will impact all disciplines, economies and industries - and it will do so at an unprecedented rate. World Economic Forum data predicts that by 2025 we will see: commercial use of nanomaterials 200 times stronger than steel and a million times thinner than human hair; the first transplant of a 3D-printed liver; 10% of all cars on US roads being driverless; and much more besides. In The Fourth Industrial Revolution, Schwab outlines the key technologies driving this revolution, discusses the major impacts on governments, businesses, civil society and individuals, and offers bold ideas for what can be done to shape a better future for all.
Eye Pathology
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Author : Steffen Heegaard
language : en
Publisher: Springer
Release Date : 2014-11-10
Eye Pathology written by Steffen Heegaard and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-10 with Medical categories.
This book is a comprehensive, in-depth, and up-to-date resource on eye pathology that will be of great practical value for ophthalmic and general pathologists and ophthalmologists. Congenital abnormalities, inflammatory conditions, infections, injuries, degenerative diseases, and tumors are all covered with the aid of more than 700 images. In the case of tumors, the wide variety of neoplasms that occur in the eyelid, conjunctiva, retina, uveal tract, lacrimal gland and sac, orbit, and optic nerve are comprehensively reviewed, and the most recent knowledge on the relation between genetics and prognosis is presented. Entries on specific diseases are organized in a standard way, with information on etiology, epidemiology, clinical presentation, pathological characteristics, differential diagnosis, therapy, and prognosis. The authors are all recognized experts and members of the European and American ophthalmic pathology societies.
Stem Cells And The Future Of Regenerative Medicine
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2002-01-25
Stem Cells And The Future Of Regenerative Medicine written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-25 with Science categories.
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Stem Cell Proliferation And Differentiation
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-03-24
Stem Cell Proliferation And Differentiation written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with Science categories.
Stem Cell Proliferation and Differentiation, Volume 138, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on stem cell proliferation and differentiation
Brain And Spinal Cord Atrophy In Multiple Sclerosis
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Author : Robert Zivadinov
language : en
Publisher: Nova Publishers
Release Date : 2005
Brain And Spinal Cord Atrophy In Multiple Sclerosis written by Robert Zivadinov and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Atrophy categories.
Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.