Outline Of Crystallography For Biologists
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Outline Of Crystallography For Biologists
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Author : David Blow
language : en
Publisher: OUP Oxford
Release Date : 2002-04-11
Outline Of Crystallography For Biologists written by David Blow and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-11 with Science categories.
Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those with minimal mathematical knowledge. Some mathematical detail is given throughout in boxes, but these can be ignored. Theory is limited to the essentials required to comprehend issues of quality. There is an extensive reference section and suggestions for further reading for those who wish to delve deeper. The first part 'Fundamentals' presents the underlying ideas which allow x-ray structure analysis to be carried out and provides an appropriate background to courses in structural determination. The second part 'Practice' gives more information about the procedures employed in the course of crystal structure determination. The emphasis is on the quality measures of X-ray diffraction analysis to give the reader a critical insight into the quality and accuracy of a structure determination and to enable the reader to appreciate which parts of a structure determination may have caused special difficulty. There is no pretence of completeness and many matters discussed in standard crystallography texts are deliberately omitted. However, issues not brought out in the standard texts are discussed, making it a useful resource for non-practising crystallographers as well.
Structural Biology In Drug Discovery
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Author : Jean-Paul Renaud
language : en
Publisher: John Wiley & Sons
Release Date : 2020-02-05
Structural Biology In Drug Discovery written by Jean-Paul Renaud and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-05 with Medical categories.
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Biomolecular Crystallography
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Author : Bernhard Rupp
language : en
Publisher: Garland Science
Release Date : 2009-10-20
Biomolecular Crystallography written by Bernhard Rupp and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-20 with Science categories.
Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.
Protein Crystallography
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Author : Eaton E. Lattman
language : en
Publisher: JHU Press
Release Date : 2008-04-28
Protein Crystallography written by Eaton E. Lattman and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-28 with Medical categories.
The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.
Principles Of Nucleic Acid Structure
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Author : Stephen Neidle
language : en
Publisher: Academic Press
Release Date : 2021-10-15
Principles Of Nucleic Acid Structure written by Stephen Neidle and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-15 with Science categories.
Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. - Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge - Defines technical terms for novices - Includes a complete list of resources, including relevant online databases and software, as well as useful websites
Structure Determination By X Ray Crystallography
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Author : Mark Ladd
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-07-08
Structure Determination By X Ray Crystallography written by Mark Ladd and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
The advances in and applications of x-ray and neutron crystallography form the essence of this new edition of this classic textbook, while maintaining the overall plan of the book that has been well received in the academic community since the first edition in 1977. X-ray crystallography is a universal tool for studying molecular structure, and the complementary nature of neutron diffraction crystallography permits the location of atomic species in crystals which are not easily revealed by X-ray techniques alone, such as hydrogen atoms or other light atoms in the presence of heavier atoms. Thus, a chapter discussing the practice of neutron diffraction techniques, with examples, broadens the scope of the text in a highly desirable way. As with previous editions, the book contains problems to illustrate the work of each chapter, and detailed solutions are provided. Mathematical procedures related to the material of the main body of the book are not discussed in detail, but are quotedwhere needed with references to standard mathematical texts. To address the computational aspect of crystallography, the suite of computer programs from the fourth edition has been revised and expanded. The programs enable the reader to participate fully in many of the aspects of x-ray crystallography discussed in the book. In particular, the program system XRAY* is interactive, and enables the reader to follow through, at the monitor screen, the computational techniques involved in single-crystal structure determination, albeit in two dimensions, with the data sets provided. Exercises for students can be found in the book, and solutions are available to instructors.
Advances In Computational Biology
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Author : Hamid R. Arabnia
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-24
Advances In Computational Biology written by Hamid R. Arabnia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-24 with Science categories.
Proceedings of The 2009 International Conference on Bioinformatics and Computational Biology in Las Vegas, NV, July 13-16, 2009. Recent advances in Computational Biology are covered through a variety of topics. Both inward research (core areas of computational biology and computer science) and outward research (multi-disciplinary, Inter-disciplinary, and applications) will be covered during the conferences. These include: Gene regulation, Gene expression databases, Gene pattern discovery and identification, Genetic network modeling and inference, Gene expression analysis, RNA and DNA structure and sequencing, Biomedical engineering, Microarrays, Molecular sequence and structure databases, Molecular dynamics and simulation, Molecular sequence classification, alignment and assembly, Image processing In medicine and biological sciences, Sequence analysis and alignment, Informatics and Statistics in Biopharmaceutical Research, Software tools for computational biology and bioinformatics, Comparative genomics; and more.
Crystallography
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Author : Anthony Michael Glazer
language : en
Publisher: Oxford University Press
Release Date : 2016
Crystallography written by Anthony Michael Glazer and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Science categories.
A long history -- Symmetry -- Crystal structures -- Diffraction -- Seeing atoms -- Sources of radiation
Macromolecular Crystallography
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Author : Mark R. Sanderson
language : en
Publisher: Oxford University Press
Release Date : 2007-08-23
Macromolecular Crystallography written by Mark R. Sanderson and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-23 with Language Arts & Disciplines categories.
Macromolecular crystallography is the study of macromolecules using X-ray crystallographic techniques to determine their molecular structure. This title synthesises contributions from a team of internationally recognized leaders, offering chapters on conventional and high-throughput methods.
The Basics Of Crystallography And Diffraction
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Author : Christopher Hammond
language : en
Publisher: OUP Oxford
Release Date : 2015-05-29
The Basics Of Crystallography And Diffraction written by Christopher Hammond and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-29 with Science categories.
This book provides a clear and very broadly based introduction to crystallography, light, X-ray and electron diffraction - a knowledge which is essential to students in a wide range of scientific disciplines but which is otherwise generally covered in subject-specific and more mathematically detailed texts. The text is also designed to appeal to the more general reader since it shows, by historical and biographical references, how the subject has developed from the work and insights of successive generations of crystallographers and scientists. The book shows how an understanding of crystal structures, both inorganic and organic may be built up from simple ideas of atomic and molecular packing. Beginning with (two dimensional) examples of patterns and tilings, the concepts of lattices, symmetry point and space groups are developed. 'Penrose' tilings and quasiperiodic structures are also included. The reciprocal lattice and its importance in understanding the geometry of light, X-ray and electron diffraction patterns is explained in simple terms, leading to Fourier analysis in diffraction, crystal structure determination, image formation and the diffraction-limited resolution in these techniques. Practical X-ray and electron diffraction techniques and their applications are described. A recurring theme is the common principles: the techniques are not treated in isolation. The fourth edition has been revised throughout, and includes new sections on Fourier analysis, Patterson maps, direct methods, charge flipping, group theory in crystallography, and a new chapter on the description of physical properties of crystals by tensors (Chapter 14).