Particulate Interactions In Dry Powder Formulations For Inhalation
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Particulate Interactions In Dry Powder Formulation For Inhalation
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Author : Xian Ming Zeng
language : en
Publisher: CRC Press
Release Date : 2000-10-26
Particulate Interactions In Dry Powder Formulation For Inhalation written by Xian Ming Zeng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-26 with Medical categories.
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
Particulate Interactions In Dry Powder Formulations For Inhalation
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Author : Xian Ming Zeng
language : en
Publisher:
Release Date : 2003
Particulate Interactions In Dry Powder Formulations For Inhalation written by Xian Ming Zeng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Inhalation Drug Delivery
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Author : Paolo Colombo
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-11
Inhalation Drug Delivery written by Paolo Colombo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-11 with Science categories.
There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.
Excipient Development For Pharmaceutical Biotechnology And Drug Delivery Systems
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Author : Ashok Katdare
language : en
Publisher: CRC Press
Release Date : 2006-07-28
Excipient Development For Pharmaceutical Biotechnology And Drug Delivery Systems written by Ashok Katdare and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-28 with Medical categories.
To facilitate the development of novel drug delivery systems and biotechnology-oriented drugs, the need for new, yet to be developed, and approved excipients continues to increase. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems serves as a comprehensive source to improve understanding of excipients and forge potential new avenues for regulatory approval. This book presents detailed, up-to-date information on various aspects of excipient development, testing, and technological considerations for their use. It addresses specific details such as historical perspective, preclinical testing, safety, and toxicology evaluation, as well as regulatory, quality, and utility aspects. The text also describes best practices for use of various functional excipients and extensive literature references for all topics.
Pulmonary Drug Delivery
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Author : Ali Nokhodchi
language : en
Publisher: John Wiley & Sons
Release Date : 2015-06-01
Pulmonary Drug Delivery written by Ali Nokhodchi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Science categories.
Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.
Handbook Of Lung Targeted Drug Delivery Systems
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Author : Yashwant Pathak
language : en
Publisher: CRC Press
Release Date : 2021-10-17
Handbook Of Lung Targeted Drug Delivery Systems written by Yashwant Pathak and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-17 with Medical categories.
Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems
Pharmaceutical Inhalation Aerosol Technology Third Edition
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Author : Anthony J. Hickey
language : en
Publisher: CRC Press
Release Date : 2019-03-26
Pharmaceutical Inhalation Aerosol Technology Third Edition written by Anthony J. Hickey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-26 with Medical categories.
This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the ‘technology’ focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors
Introduction To Particle Technology
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Author : Martin J. Rhodes
language : en
Publisher: John Wiley & Sons
Release Date : 2024-07-15
Introduction To Particle Technology written by Martin J. Rhodes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-15 with Science categories.
INTRODUCTION TO PARTICLE TECHNOLOGY A new edition of the indispensable guide to particulates and powders Particle technology concerns the formation, processing and properties of the particles and powders which make up many of the products that surround us. Such products range from the cement and aggregate in the built environment to pharmaceuticals and processed foods. Most of the process industries involve particles, either as essential components such as catalysts or as intermediate or final products, and minerals such as the rare earths that are generally mined and processed in particulate form. Particles can have many beneficial uses but they can also cause harm in the environment and, through inhalation, to the individual. In all cases, the powder properties, particularly particle size, are crucially important. This well-known textbook, now in its 3rd edition, provides an easily-understood introduction to the underlying scientific principles of particle technology, together with examples of how these principles can be used in practical design and operation of industrial processes. Each chapter contains both worked examples and exercises for the student. Based on feedback from students and users of the earlier editions, this revised and expanded text includes introductory chapters on particles as products and on computational methods. The topics have been selected to give coverage of the broad areas of particle technology and include: Characterization (size analysis, surface area) Processing (granulation, fluidization) Particle formation (granulation, crystallisation, tableting, size reduction) Storage and transport (hopper design, pneumatic conveying, standpipes) Separation (filtration, settling, cyclones) Safety (fire and explosion hazards, health hazards) Engineering the properties of particulate systems to achieve desired product performance Discrete element modelling of particulate systems Introduction to Particle Technology, 3rd Edition is essential reading for students of chemical engineering. The text is also recommended reading for students of mechanical engineering, applied chemistry, pharmaceutics, physics, mineral processing, and metallurgy, and is an excellent source for practising engineers and scientists looking to establish a working knowledge of the subject.
Fundamentals Of Drug Delivery
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Author : Heather A. E. Benson
language : en
Publisher: John Wiley & Sons
Release Date : 2021-09-30
Fundamentals Of Drug Delivery written by Heather A. E. Benson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with Medical categories.
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Controlled Pulmonary Drug Delivery
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Author : Hugh D.C. Smyth
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-24
Controlled Pulmonary Drug Delivery written by Hugh D.C. Smyth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-24 with Medical categories.
The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.