Pathways

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Pathways To Exploration

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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2014-09-30

Pathways To Exploration written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-30 with Science categories.

The United States has publicly funded its human spaceflight program on a continuous basis for more than a half-century, through three wars and a half-dozen recessions, from the early Mercury and Gemini suborbital and Earth orbital missions, to the lunar landings, and thence to the first reusable winged crewed spaceplane that the United States operated for three decades. Today the United States is the major partner in a massive orbital facility - the International Space Station - that is becoming the focal point for the first tentative steps in commercial cargo and crewed orbital space flights. And yet, the long-term future of human spaceflight beyond this project is unclear. Pronouncements by multiple presidents of bold new ventures by Americans to the Moon, to Mars, and to an asteroid in its native orbit, have not been matched by the same commitment that accompanied President Kennedy\'s now fabled 1961 speech-namely, the substantial increase in NASA funding needed to make it happen. Are we still committed to advancing human spaceflight? What should a long-term goal be, and what does the United States need to do to achieve it? Pathways to Exploration explores the case for advancing this endeavor, drawing on the history of rationales for human spaceflight, examining the attitudes of stakeholders and the public, and carefully assessing the technical and fiscal realities. This report recommends maintaining the long-term focus on Mars as the horizon goal for human space exploration. With this goal in mind, the report considers funding levels necessary to maintain a robust tempo of execution, current research and exploration projects and the time/resources needed to continue them, and international cooperation that could contribute to the achievement of spaceflight to Mars. According to Pathways to Exploration, a successful U.S. program would require sustained national commitment and a budget that increases by more than the rate of inflation. In reviving a U.S. human exploration program capable of answering the enduring questions about humanity's destiny beyond our tiny blue planet, the nation will need to grapple with the attitudinal and fiscal realities of the nation today while staying true to a small but crucial set of fundamental principles for the conduct of exploration of the endless frontier. The recommendations of Pathways to Exploration provide a clear map toward a human spaceflight program that inspires students and citizens by furthering human exploration and discovery, while taking into account the long-term commitment necessary to achieve this goal.

Pathways

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Author : Timothy J. Kahn
language : en
Publisher:
Release Date : 1999

Pathways written by Timothy J. Kahn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Juvenile Nonfiction categories.

Grasped Pathways To Excellence

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Author : Steven Brough
language : en
Publisher: GRASPED Digital
Release Date : 2024-02-29

Grasped Pathways To Excellence written by Steven Brough and has been published by GRASPED Digital this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-29 with Business & Economics categories.

"GRASPED Pathways to Excellence" is envisioned as a comprehensive guide aimed at individuals seeking transformation in both personal and professional spheres. It likely presents 20 innovative strategies designed to navigate through the complexities of achieving excellence, covering a broad spectrum from enhancing leadership skills, adopting new technologies for growth, to fostering personal well-being and creativity. This guide's USP may lie in its dual focus on personal and professional development, offering a holistic approach rarely found in traditional business or self-help books. It emphasizes the interconnectedness of personal well-being and professional success, providing readers with a unique toolkit designed for the modern landscape of work and life. An introduction to "GRASPED Pathways to Excellence" might set the stage for a transformative journey, highlighting the book's commitment to fostering growth, innovation, and balance. It could invite readers to explore new dimensions of success, promising not just strategies but a new perspective on excellence.

Grasped Pathways To Entrepreneurial Mastery

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Author : Steven Brough
language : en
Publisher: GRASPED Digital
Release Date : 2024-02-29

Grasped Pathways To Entrepreneurial Mastery written by Steven Brough and has been published by GRASPED Digital this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-29 with Business & Economics categories.

"GRASPED Pathways to Entrepreneurial Mastery" unfolds as an insightful guide to mastering the dual realms of business and personal growth. With 20 essential strategies, it covers innovation, leadership, digital transformation, and personal well-being. The book is structured to offer practical advice, real-world examples, and actionable steps for entrepreneurs aiming for success in both their professional and personal lives. What sets this guide apart is its holistic approach, seamlessly blending business acumen with personal development. It's unique in offering a dual path to mastery, emphasizing the synergy between personal well-being and entrepreneurial success, thus equipping readers for the challenges of a rapidly evolving business landscape while also fostering personal integrity and growth. Embark on a transformative journey with "GRASPED Pathways to Entrepreneurial Mastery." This book is a beacon for ambitious individuals, guiding them through the complexities of entrepreneurship while also nurturing personal growth. It's designed not just as a business guide but as a comprehensive roadmap to achieving a harmonious balance between professional achievements and personal fulfillment.

Cancer Stem Cells And Signaling Pathways

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Author : Surajit Pathak
language : en
Publisher: Elsevier
Release Date : 2023-11-01

Cancer Stem Cells And Signaling Pathways written by Surajit Pathak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-01 with Science categories.

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Multiple Pathways To The Student Brain

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Author : Janet Zadina
language : en
Publisher: John Wiley & Sons
Release Date : 2014-06-09

Multiple Pathways To The Student Brain written by Janet Zadina and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-09 with Education categories.

From an award-winning neuroscience researcher with twenty years of teaching experience, Multiple Pathways to the Student Brain uses educator-friendly language to explain how the brain learns. Steering clear of “neuro-myths,” Dr. Janet Zadina discusses multiple brain pathways for learning and provides practical advice for creating a brain-compatible classroom. While there are an abundance of books and workshops that aim to integrate education and brain science, educators are seldom given concrete, actionable advice that makes a difference in the classroom. Multiple Pathways to the Student Brain bridges that divide by providing examples of strategies for day-to-day instruction aligned with the latest brain science . The book explains not only the sensory/motor pathways that are familiar to most educators (visual, auditory, and kinesthetic), it also explores the lesser known pathways--reward/survival, language, social, emotional, frontal lobe, and memory/attention--and how they can be tapped to energize and enhance instruction. Educators are forever searching for new and improved ways to convey information and inspire curiosity, and research suggests that exploiting different pathways may have a major effect on learning. Multiple Pathways to the Student Brain allows readers to see brain science through the eyes of a teacher—and teaching through the eyes of a brain scientist.

Pathway Analysis For Drug Discovery

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Author : Anton Yuryev
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-17

Pathway Analysis For Drug Discovery written by Anton Yuryev and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-17 with Science categories.

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Cell And Molecular Signaling And Transport Pathways Involved In Growth Factor Control Of Synaptic Development And Function

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Author : Akira Yoshii
language : en
Publisher: Frontiers Media SA
Release Date : 2015-08-31

Cell And Molecular Signaling And Transport Pathways Involved In Growth Factor Control Of Synaptic Development And Function written by Akira Yoshii and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-31 with Molecular biology categories.

Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field.

Pathways To Success

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Author : Nick Salafsky
language : en
Publisher: Island Press
Release Date : 2021-12-02

Pathways To Success written by Nick Salafsky and has been published by Island Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-02 with Nature categories.

As environmental problems grow larger and more pressing, conservationists have had to adapt. With a shrinking window of time to act, they are turning to broad approaches to combat continental- and global-scale crises of biodiversity loss, invasive species, and climate change. Pathways to Success—the long-awaited successor to the classic volume Measures of Success—is a modern guide to building large-scale transformative programs capable of tackling the complex conservation crises we face today. In this strikingly illustrated volume, coauthors Nick Salafsky and Richard Margoluis walk readers through fundamental concepts of effective program-level design, helping them to think strategically about project coordination, funding, and stakeholder input. Chapters in the first part of the book look at all aspects of designing and implementing large-scale conservation programs while the second part focuses on how to use data and information to manage, adapt, and learn from program strategies. In addition, the authors offer practical advice for avoiding pitfalls, such as formulaic recipes and simplistic silver-bullet solutions that can trip up otherwise well-intentioned efforts. Abundant graphics help to explain and clarify concepts presented in the text, and a glossary in the back matter defines technical terms for the reader. Pathways to Success is the definitive guide for conservation program managers and funders who want to increase the scale and effectiveness of their work combating biodiversity loss, climate change, and other pressing environmental issues.

Signalling Pathways In Embryonic Development

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Author : Juan J. Sanz-Ezquerro
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-30

Signalling Pathways In Embryonic Development written by Juan J. Sanz-Ezquerro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-30 with categories.

The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.