Pegylated Protein Drugs Basic Science And Clinical Applications
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Pegylated Protein Drugs Basic Science And Clinical Applications
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Author : Francesco M. Veronese
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-30
Pegylated Protein Drugs Basic Science And Clinical Applications written by Francesco M. Veronese and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-30 with Medical categories.
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Nano Enabled Medical Applications
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Author : Lajos P. Balogh
language : en
Publisher: CRC Press
Release Date : 2020-11-23
Nano Enabled Medical Applications written by Lajos P. Balogh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-23 with Medical categories.
This book is the second in a series presenting articles that received the most citations in recent years in nanomedicine. The series is edited by, a prominent nanotechnology researcher and editor-in-chief of Precision Nanomedicine. The theme of the second volume is about nano-enabled medical applications. The 19 articles collected here have already acquired more than 12,500 citations highlighting the importance and professional recognition of the work of these scientists in nanomedicine. The content includes the general overview of the field and a wide variety of applications that have been impossible without nanoscience and nanotechnology.
Nanoengineering Of Biomaterials
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Author : Sougata Jana
language : de
Publisher: John Wiley & Sons
Release Date : 2022-04-18
Nanoengineering Of Biomaterials written by Sougata Jana and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-18 with Science categories.
A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.
Polymer Protein Conjugates
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Author : Gianfranco Pasut
language : en
Publisher: Elsevier
Release Date : 2019-10-30
Polymer Protein Conjugates written by Gianfranco Pasut and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-30 with Technology & Engineering categories.
Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field
Sterile Product Development
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Author : Parag Kolhe
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-12
Sterile Product Development written by Parag Kolhe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-12 with Medical categories.
This comprehensive book encompasses various facets of sterile product development. Key concepts relevant to the successful development of sterile products are illustrated through case studies and are covered under three sections in this book: • Formulation approaches that discuss a variety of dosage forms including protein therapeutics, lipid-based controlled delivery systems, PEGylated biotherapeutics, nasal dosage form, and vaccines • Process, container closure and delivery considerations including freeze-thaw process challenges, best practices for technology transfer to enable commercial product development, innovations and advancement in aseptic fill-finish operations, approaches to manufacturing lyophilized parenteral products, pen / auto-injector delivery devices, and associated container closure integrity testing hurdles for sterile product closures • Regulatory and quality aspects in the areas of particulate matter and appearance evaluation, sterile filtration, admixture compatibility considerations, sterilization process considerations, microbial contamination investigations and validation of rapid microbiological methods, and dry and moist heat sterilizers This book is a useful resource to scientists and researchers in both industry and academia, and it gives process and product development engineers insight into current industry practices and evolving regulatory expectations for sterile product development.
Long Acting Injections And Implants
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Author : Jeremy C. Wright
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-14
Long Acting Injections And Implants written by Jeremy C. Wright and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-14 with Medical categories.
This book surveys the field of long acting injections and implants, which improve therapy, enhance patient compliance, and enhance dosing convenience. Topics include the historical development of drugs and diseases, and clinical applications for long acting injections and implants.
Polyphosphazenes For Medical Applications
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Author : Ian Teasdale
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2020-09-07
Polyphosphazenes For Medical Applications written by Ian Teasdale and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-07 with Technology & Engineering categories.
This book describes preparation techniques for well-defined, customizable poly(organo)phosphazene materials and their applications in nanomedicine, i.e. as macromolecular carriers for drug delivery, immunology, gene therapy, or tissue regeneration. This 2nd edition of Polyphosphazenes for Medical Applications has been updated and extended for researchers in the field as well as those considering using polyphosphazenes for a specific application.
Continuous Biopharmaceutical Processes
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Author : David Pfister
language : en
Publisher: Cambridge University Press
Release Date : 2018-10-11
Continuous Biopharmaceutical Processes written by David Pfister and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-11 with Medical categories.
Provides a coherent and critical view on the potential benefits of various continuous processes in the biopharmaceutical industry.
Polymers In Regenerative Medicine
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Author : Manuel Monleon Pradas
language : en
Publisher: John Wiley & Sons
Release Date : 2015-02-02
Polymers In Regenerative Medicine written by Manuel Monleon Pradas and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-02 with Technology & Engineering categories.
Biomedical applications of Polymers from Scaffolds to Nanostructures The ability of polymers to span wide ranges of mechanical properties and morph into desired shapes makes them useful for a variety of applications, including scaffolds, self-assembling materials, and nanomedicines. With an interdisciplinary list of subjects and contributors, this book overviews the biomedical applications of polymers and focuses on the aspect of regenerative medicine. Chapters also cover fundamentals, theories, and tools for scientists to apply polymers in the following ways: Matrix protein interactions with synthetic surfaces Methods and materials for cell scaffolds Complex cell-materials microenvironments in bioreactors Polymer therapeutics as nano-sized medicines for tissue repair Functionalized mesoporous materials for controlled delivery Nucleic acid delivery nanocarriers Concepts include macro and nano requirements for polymers as well as future perspectives, trends, and challenges in the field. From self-assembling peptides to self-curing systems, this book presents the full therapeutic potential of novel polymeric systems and topics that are in the leading edge of technology.
Comprehensive Biomaterials Ii
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Author : Kevin Healy
language : en
Publisher: Elsevier
Release Date : 2017-05-18
Comprehensive Biomaterials Ii written by Kevin Healy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-18 with Technology & Engineering categories.
Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications