Peptide Hormones In Lung Cancer

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Peptide Hormones In Lung Cancer

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Author : Klaus Havemann
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Peptide Hormones In Lung Cancer written by Klaus Havemann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

The incidence of lung cancer has reached epidemic proportions throughout the civilized world. One indication of the dimensions of this problem is that in the United States lung cancer has become the leading cause of cancer death in women as well as men. In 1912 there was a "nearly complete consensus of opinion that primary malignant neoplasms of the lung (were one) of the rarest forms of disease," according to Adler. By 1937, however, it had become clear that the incidence of lung cancer was increasing significantly; this increase has been progressive ever since. It is now well known that some lung cancers give rise to a variety of hormones which, at times, produce clinical manifestations. The association of hormone production with a "nonendocrine" tumor raises many questions, the answers to which may shed some light on the etiology of this prevalent form of cancer. This fascinating prob lem has stimulated a wide variety of studies in both the clinical and the basic sciences. A number of the more recent studies in this field were discussed at the International Symposium on Peptide Hor mones and Lung Cancer held in Marburg, West Germany, on June 18-20, 1984. This volume contains the papers that were pre sented on this occasion.

Peptide Hormones As Mediators In Immunology And Oncology

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Author : Rolf-Dieter Hesch
language : en
Publisher: Raven Press (ID)
Release Date : 1985

Peptide Hormones As Mediators In Immunology And Oncology written by Rolf-Dieter Hesch and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.

Clinical And Experimental Pathology Of Lung Cancer

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Author : J. Gordon McVie
language : en
Publisher: Springer Science & Business Media
Release Date : 1986

Clinical And Experimental Pathology Of Lung Cancer written by J. Gordon McVie and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.

J. G. MCVIE The impact of therapy on one subset of lung cancer, the "small cell" type has been significant and lasting. The reality of cure for even a fraction of patients with this disease has caused reverberations in the pathology lab where the responsibili. '~y and challenge of diagnosis of this vital sub group lies. No less dramatic has been the discovery that the cell types of lung cancer have recognisable growth characteristics in serum free culture, they are recognisable by patterns of markers and some produce growth factors which autoregulate their eventual fate. Many of the discoveries from the biological studies have impacted on the pathologist in the form of disturbing evidence for a single stem cell origin for all the cell types of lung cancer and in the shape of new facilitation in diagnosis by appli cation of immunoperoxidase techniques. Monoclonal antibodies raised against oncogene products, growth factor receptor sites, "bystander" cell membrane proteins can all be applied to cytology specimens and frozen or paraffin fixed tissue sections to aid diagnosis and some can be used in sequential serum assay to monitor therapy and predict prognosis. Adding to these extraordinary tools, the sophistication of electron micro scopy and immuno-electrcn microscopy, new techniques for preparation of tissue and novel methods for studying vital cells in "kinesis", you sense the flavour of the future of lung cancer which is captured in this book.

Small Cell Lung Cancer

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Author : Siegfried Seeber
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Small Cell Lung Cancer written by Siegfried Seeber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Effective Regulation Of Peptide Hormones

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Author : Feihua Cao
language : en
Publisher:
Release Date : 2012

Effective Regulation Of Peptide Hormones written by Feihua Cao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Peptide hormones categories.

In the work described in this thesis, peptidylglycine a-amidating monooxygenase (PAM) was extracted from human H889 and DMS53 small cell lung cancer (SCLC) cells, PC-3 prostate cancer cells and SW1783 glioblastoma cells. Optimization of PAM assay conditions was carried out to maximize PAM activity. The extracted enzymes and optimized assay conditions provided a platform to assess substrate and inhibitor kinetic parameters and to compare the enzyme specificities of PAM from different human cancer sources, as well as differences between human PAM and commercial frog PAM. Potent and selective PAM inhibitors were then developed on the basis of structure-activity-relationships as well as the recognition by PAM of the peptide chain of natural substrates. Furthermore, a direct, rapid, efficient and sensitive HPLC method was developed in order to carry out whole cell inhibition studies and to directly monitor the inhibitory effects on natural hormone and prohormone levels. This method includes online extraction, separation, derivatization and fluorescence detection of peptide hormones, and in principle could be used for any peptide hormone with a free primary amine for fluorescamine tagging. Calcitonin (CT) and its prohormones were studied due to their high expression in DMS53 cells. This is the first time that the levels of CT and its prohormones, CTG, CTGK and CTGKK, have been separated and quantified separately. The detection limits of the present HPLC method were determined to be around 1 ng/mL of cell medium. This method was then applied to whole cell inhibition studies, and this is the first time that inhibitors of CT biosynthesis in human cancer cells were studied, allowing the direct observation of the effects on CT levels and its prohormones. As CPE and PAM are involved in the specific cleavage of C-terminal basic amino acids and the last step of peptide bioactivation, respectively, CPE was also targeted to moderate CT levels. The newly developed whole cell PAM inhibition assay allowed direct determination of the effects of PAM and CPE inhibition on CT production.

Endocrine Tumours

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Author : Julia M. Polak
language : en
Publisher:
Release Date : 1985

Endocrine Tumours written by Julia M. Polak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.

Peptides In Oncology Ii

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Author : K. Höffken
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Peptides In Oncology Ii written by K. Höffken and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This second of two volumes presents the state of the art in somatostatin analogues and bombesin antagonists in neoplastic diseases. It provides a detailed description of mechanisms of action and the present clinical relevance of these new approaches in cancer treatment. Each chapter has been prepared by an expert active in the respective experimental and/or clinical field so that the reader is assured of obtaining the latest information on the topic.

Regulatory Peptides And Amines During Ontogeny And In Non Endocrine Cancers

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Author : Lars-Inge Larsson
language : en
Publisher:
Release Date : 1988

Regulatory Peptides And Amines During Ontogeny And In Non Endocrine Cancers written by Lars-Inge Larsson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Amino acids categories.

Hormonal Manipulation Of Cancer

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Author : Jan G. M. Klijn
language : en
Publisher:
Release Date : 1987

Hormonal Manipulation Of Cancer written by Jan G. M. Klijn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.

Recent Results In Cancer Research

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Author :
language : en
Publisher:
Release Date : 1985

Recent Results In Cancer Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Cancer categories.