Polarization Based Optical Imaging With The Application To Cancer Diagnostics
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Optical Detection Of Cancer
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Author : Arlen D. Meyers
language : en
Publisher: World Scientific
Release Date : 2011-04-30
Optical Detection Of Cancer written by Arlen D. Meyers and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-30 with Technology & Engineering categories.
Significant progress in engineering has allowed the production of devices that can optically detect, differentiate and treat surface or near-surface cancers. The ability to differentiate cancerous from non-cancerous tissue in vitro using light represents a potentially significant advance in patient care, eliminating needless repeat procedures. With the help of advanced optical technologies, clinicians are able to identify cancers earlier, determine surgical margins at the time of surgery, and monitor treatment results without using expensive and insensitive imaging. This volume describes the state-of-the-art optical detection technologies in varying stages of cancer development. Written by an international panel of basic researchers, engineers and clinicians, the book is designed to give an up-to-date overview of the most recent advances for researchers and medical professionals who are interested in the biophotonic detection of cancer.
Multimodal Optical Diagnostics Of Cancer
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Author : Valery V. Tuchin
language : en
Publisher: Springer
Release Date : 2021-10-24
Multimodal Optical Diagnostics Of Cancer written by Valery V. Tuchin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-24 with Medical categories.
This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource. Introduces optical imaging strategies; Focuses on multimodal optical diagnostics as a fundamental approach; Discusses novel methods of optical non-invasive cancer diagnostics.
Polarization Based Optical Imaging With The Application To Cancer Diagnostics
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Author : Gang L. Liu
language : en
Publisher:
Release Date : 2002
Polarization Based Optical Imaging With The Application To Cancer Diagnostics written by Gang L. Liu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Melanoma categories.
Optical Imaging Of Cancer
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Author : Eben Rosenthal
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-03
Optical Imaging Of Cancer written by Eben Rosenthal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-03 with Medical categories.
To describe principles of optical imaging including chemistry and physics of fluorescence, limitations/advantages of optical imaging compared to metabolic and anatomic imaging. Describe hardware adapted for small animal imaging and for clinical applications: endoscopes and operative microscopes. Outline FDA approved and newer optical imaging probes. Include discussion of chemistry and linkage to other proteins. Review current techniques to image cancer and the development of techniques to specifically image cancer cells. Review use of exploiting differences in tissue autofluorescence to diagnose and treat cancer. Include agents such as 5-aminoleculinic acid. Review mechanisms that require proteolytic processing within the tumor to become active fluorophores. Review use of cancer selective proteins to localize probes to cancer cells: include toxins, antibodies, and minibodies. Introduction of plasmids, viruses or other genetic material may be used to express fluorescent agents in vivo. This chapter will review multiple vectors and delivery mechanisms of optical imaging cassettes.Preclinical investigations into the use of optical contrast agents for the detection of primary tumors in conventional and orthotopic models will be discussed. Preclinical investigations into the use of optical contrast agents for the detection of metastatic tumors in mouse models will be discussed. Use of targeted and non-specific optical contrast agents have been used for the detection of sentinel lymph node detection. These applications and how they differ from other applications will be discussed. Because of the unique difficulty of identifying tumor from normal tissue in brain tissue, a separate chapter would be needed. More clinical data is available for this cancer type than any other. Discussion of potential clinical applications for optical imaging and an assessment of the potential market.
Optical Spectroscopy And Imaging For Cancer Diagnostics Fundamentals Progress And Challenges
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Author : Noureddine Melikechi
language : en
Publisher: World Scientific
Release Date : 2023-01-06
Optical Spectroscopy And Imaging For Cancer Diagnostics Fundamentals Progress And Challenges written by Noureddine Melikechi and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-06 with Technology & Engineering categories.
This is an interdisciplinary book that presents the applications of novel laser spectroscopy and imaging techniques for the detection of cancers recently developed by some of the world's most renown researchers. The book consists of three parts and a total of 16 chapters. Each chapter is written by leading experts who are actively seeking to develop novel spectroscopic and analytical methods for cancer detection and diagnosis.In Part I, the authors present fundamentals on optics, atoms and molecules, biophysics, cancer and machine learning. These chapters are intended for those who are not experts in the field but wish to learn about fundamentals' aspects of some of the key topics that are addressed in this book. Particular attention has been given to providing key references for those who wish to go further into the fundamental aspects of atoms and molecules, light-matter interaction, optical instrumentation, machine learning and cancer.In Part II, the authors present key applications of various laser spectroscopic methods in cancer diagnosis. They have provided recent progress in cancer diagnostics obtained by combining laser spectroscopy and machine learning for the analysis of the spectra acquired from biomedical tissues and biofluids.In Part III, the authors present chapters that discuss key developments in the applications of various laser imaging techniques for cancer detection.This is one of the few books that addresses cancer detection and diagnosis using laser spectroscopic and imaging tools with an eye on providing the reader the scientific tools, including machine learning ones.
Enhanced Multispectral Polarimetric Imaging Techniques Utilizing An Optical Tumor Phantom
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Author : Srinivasan Sukumar
language : en
Publisher:
Release Date : 2005
Enhanced Multispectral Polarimetric Imaging Techniques Utilizing An Optical Tumor Phantom written by Srinivasan Sukumar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Diagnostic imaging categories.
"The purpose of this research was to investigate the potential of a laser-based optical polarimetric imaging system, operating under light backscattering geometry, for tumor detection utilizing an optical tumor phantom. Image plays a key role in tumor detection studies. The polarization state of the scattered light from a tumor-like structure and the discrimination of randomly polarized light from weakly polarized light can provide meaningful information regarding the nature of the tumor itself. This information can be both physiological and structural. In this research study, experiments were performed at two optical wavelengths, one visible and one near-infrared wavelength. The weakly scattered light from the tumor tissue like phantom had the necessary information relevant to the structure of the tumor. A Rotating Retarder Polarimeter was used to analyze this weakly scattered light from the phantom. The images obtained from the Rotating Retarder Polarimeter were then processed by means of a data reduction algorithm, based on Polarimetric Measurement matrix method to calculate the Degree of Linear Polarization (DOLP) image. Then, the DOLP images obtained from the two different wavelength lasers were subtracted to enhance the information present in the image. The Signal-to-Background ratio, a measure of contrast, was calculated to determine the quality of the image. Results from the experiments and the contrast analysis procedures showed that, the subtracted DOLP images provides better contrast in terms of higher numerical value compared to the single DOLP image. Overall, this optical imaging system combined with data reduction algorithm and image processing technique served as an effective imaging methodology in optical tumor phantom study."--Page iii-iv.
Cancer Diagnostics Using Dynamic Near Infrared Optical Imaging And Fluorescent Contrast Agents
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Author : Mikhail Gurfinkel
language : en
Publisher:
Release Date : 2006
Cancer Diagnostics Using Dynamic Near Infrared Optical Imaging And Fluorescent Contrast Agents written by Mikhail Gurfinkel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
A new optical imaging modality has been developed for small animal in vivo imaging of near-infrared fluorescence resulting from fluorescent contrast agents specifically targeted to molecular markers of cancer. The imaging system is comprised of an intensified charge-coupled device (ICCD) for the detection of ultra-low levels of re-emitted fluorescence following the delivery of an expanded beam of excitation light. The design of the ICCD detection system allows for both continuous wave (CW) and frequency-domain modes of operation. Since the accurate acquisition of frequency-domain photon migration (FDPM) data is important for tomographic imaging, the imaging system was also validated using experimentally obtained FDPM measurements of homogenous turbid media and diffusion theory to obtain estimates of the optical properties characteristic of the media. The experiments demonstrated that the absorption and reduced scattering coefficients are determined least accurately when relative measurements of average light intensity I rel [over] DC are employed either alone or in a combination with relative modulation amplitude data I rel [over] AC and/or relative phase shift data [theta] [superscript]rel. However, when FDPM measurements of [theta] [superscript]rel are employed either alone or in combination with I rel [over] AC data, the absorption and reduced scattering coefficients may be found accurate to within 15% and 11%, respectively, of the values obtained from standard single-pixel measurements; a result that suggests that FDPM data obtained from an ICCD detection system may in fact be useful in tomographic imaging. Furthermore, intensified-detection allows for sub-second exposure times, permitting the acquisition of dynamic fluorescence images immediately following administration of the contrast agent. Experimental results demonstrate that when coupled with a suitable pharmacokinetic model describing targeted dye distribution throughout the body, dynamic fluorescence imaging may be used to discriminate spontaneous canine adenocarcinoma from normal mammary tissue. A separate experiment demonstrates that pharmacokinetic analysis of dynamic fluorescence images enables one to estimate the rate constant governing Kaposi's sarcoma tumor uptake of an [alpha subscriptV beta]3 integrin-targeted dye and integrin receptor turnover rate. The rate constant for uptake was calculated to be 0.16-sec−1 while the turnover rate of the integrin receptor was estimated to occur within 24-hours.
Optical Diagnostics Biomedical Applications
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Author : Macie Holloway
language : en
Publisher: Foster Academics
Release Date : 2023-09-19
Optical Diagnostics Biomedical Applications written by Macie Holloway and has been published by Foster Academics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Medical categories.
Optical diagnostics is a specialized field of diagnostics that makes use of optical imaging. It is a technique that enables medical practitioners to look inside the body in a non-invasive manner. Optical imaging makes use of visible light and the special properties of photons to obtain detailed images of organs, tissues, cells and molecules. Optical diagnostics help in diagnosing various pathological disorders of biological tissues. There are several biomedical applications of optical diagnostics. The major advantage of optical imaging is that it offers minimally invasive or non-invasive methods for looking inside the body. Optical diagnostics also reduces a patient's exposure to harmful radiation. It can be used to measure metabolic changes that can act as early indicators of abnormal functioning of organs and tissues. A combination of optical imaging with other imaging techniques like MRI or X-rays can provide enhanced information to monitor complex diseases. The objective of this book is to give a general view of optical diagnostics and its biomedical applications. Researchers and students in this field will be assisted by this book.
Advances In Optical Imaging For Clinical Medicine
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Author : Nicusor Iftimia
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-27
Advances In Optical Imaging For Clinical Medicine written by Nicusor Iftimia and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-27 with Science categories.
This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.
Optical Imaging In Biological Tissues And Tissue Phantoms
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Author : Prashant Shukla
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012-04
Optical Imaging In Biological Tissues And Tissue Phantoms written by Prashant Shukla and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04 with Cancer categories.
The early detection and subsequent prevention of cancer have been a challenging task for researchers all over the world. Some of the conventional techniques used for the diagnosis of cancer are mammography, ultrasonography, magnetic resonance imaging (MRI), positron emission tomography (PET) and histopathology. In recent years, optical imaging is being developed as powerful techniques for the early and quick diagnosis of cancer. This book provides the information about polarimetric techniques and their applications in diagnosis of cancer in biological tissues. Polarization gating and Mueller decomposition imaging technique were addressed in the detail with their applications on cervical tissues and mimic of tissues (tissue phantoms). Polarization gated imaging can be used to detect mature tumors in the superficial layers. However, Mueller decomposition images have shown promising results about dysplasia in human cervical tissues. These images can be used to discriminate normal cervical tissue against the dysplastic (pre-cancerous) tissue. These results can be useful for clinical purposes and in the research work for diagnostic tools