Preclinical Research In Down Syndrome
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Preclinical Research In Down Syndrome
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Author : Mara Dierssen
language : en
Publisher: Academic Press is
Release Date : 2020
Preclinical Research In Down Syndrome written by Mara Dierssen and has been published by Academic Press is this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Down syndrome categories.
Preclinical Research In Down Syndrome Insights For Pathophysiology And Treatments
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-02-10
Preclinical Research In Down Syndrome Insights For Pathophysiology And Treatments written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-10 with Science categories.
Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more. Presents content by renowned authors who review the state-of-the-art in preclinical research and provide their views and perspectives for the future of the field Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Advances In Down Syndrome Research
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Author : Gert Lubec
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Advances In Down Syndrome Research written by Gert Lubec and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Medical categories.
"Advances in Down Syndrome Research” represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes.
Handbook Of Down Syndrome Research
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Author : Dominicus Jelinek
language : en
Publisher: Nova Biomedical Books
Release Date : 2014-05-14
Handbook Of Down Syndrome Research written by Dominicus Jelinek and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Down syndrome categories.
Handbook Of Down Syndrome Research
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Author : Dominicus Jelinek
language : en
Publisher: Nova Science Publishers
Release Date : 2009
Handbook Of Down Syndrome Research written by Dominicus Jelinek and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Down syndrome categories.
Down syndrome is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. It affects about 1 in every 800 babies. The physical features and medical problems associated with Down syndrome can vary widely from child to child. In most cases, the child has short and squat body, big neck, macroglossia, hypotonia and handheld fold. While some kids with DS need a lot of medical attention, others lead healthy lives. Though Down syndrome cannot be prevented, it can be detected before a child is born. Furthermore, while some kids with DS have no significant health problems, others may experience a host of medical issues that require extra care. For example, almost half of all children born with DS will have a congenital heart defect. Kids with Down syndrome are also at an increased risk of developing pulmonary hypertension. This book examines this genetic disorder, the detection of possible causes and treatment options for the complications of the disease.
Advances In Research On Down Syndrome
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Author : Subrata Dey
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-01-31
Advances In Research On Down Syndrome written by Subrata Dey and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-31 with Medical categories.
This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome.
New Developments In Down Syndrome Research
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Author : Alard van den Bosch
language : en
Publisher: Nova Science Publishers
Release Date : 2012
New Developments In Down Syndrome Research written by Alard van den Bosch and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Down syndrome categories.
Down syndrome (Trisomy 21), is characterised by the presence of an extra chromosome 21, and is the most common chromosomal abnormality. Clinical symptoms of Down syndrome (DS) often include orthopaedic, cardiovascular, neurological, cognitive, perceptual and motor impairments. In this book, the authors present current research from across the globe on Down syndrome. Topics discussed in this compilation include the effects of regular versus special school placement of students with Down syndrome; the clinical association between disorders of the ENS and Down syndrome; the impact of environmental risk factors on maternal meiotic errors; genomic implications of gene dosage imbalance in autosomal trisomy during neural development; parenting stress in families with Down syndrome children; using technology in the evaluation of Down syndrome children's social-cognitive skills; and atypical postural behaviours in individuals with DS.
The Neurobiology Of Aging And Alzheimer Disease In Down Syndrome
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Author : Elizabeth Head
language : en
Publisher: Academic Press
Release Date : 2021-08-31
The Neurobiology Of Aging And Alzheimer Disease In Down Syndrome written by Elizabeth Head and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Medical categories.
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Down Syndrome Neurodegeneration And Dementia
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Author : Sylvia Eva Perez
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27
Down Syndrome Neurodegeneration And Dementia written by Sylvia Eva Perez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
Down Syndrome
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Author : Ira T. Lott
language : en
Publisher: Wiley
Release Date : 1992-05-04
Down Syndrome written by Ira T. Lott and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-05-04 with Science categories.
Focuses entirely on health care of people with Down Syndrome throughout their life span, from birth to old age. With the remarkable strides that have been made in research and medicine in the past decade, people with Down Syndrome are living longer and healthier lives and are actively participating in all aspects of community life. Health care is a critical factor in this process. The first section explores the genetic basis for Down Syndrome as well as discusses speech and language development in children; the second section highlights clinical advances in treatment.