Protease Inhibitors Potential And Constraints
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Protease Inhibitors
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Author : Neha Khandelwal
language : en
Publisher:
Release Date : 2013-09
Protease Inhibitors written by Neha Khandelwal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09 with categories.
Scientific Study from the year 2011 in the subject Biology - Human Biology, grade: -, - (National Chemical Laboratory, Pune), course: Post Graduate Doctoral Studies, language: English, abstract: This book chapter covers the previous and current research on plant protease inhibitors being conducted worldwide since its identification. Plant protease inhibitors exists as natural defense mechanism in plants. Solanaceous plants have highly been explored for the protease inhibitor expression and function against various insects of the order lepidoptera, coleoptera, diptera and many more. Plant protease inhibitors are the well studied class of plant defensive proteins. High level of up-regulation upon insect damage, significantly elevated levels in reproductive and storage organs as well as specificity to pest proteases ascertain their defensive function. In the present chapter, we introduced molecular basis of plant-insect interactions and focused on different classes of protease inhibitors based on their target protease(s).
Protease Inhibitors Potential And Constraints
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Author : Neha Khandelwal
language : en
Publisher: GRIN Verlag
Release Date : 2013-02-26
Protease Inhibitors Potential And Constraints written by Neha Khandelwal and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-26 with Science categories.
Scientific Study from the year 2011 in the subject Biology - Human Biology, , course: Post Graduate Doctoral Studies, language: English, abstract: This book chapter covers the previous and current research on plant protease inhibitors being conducted worldwide since its identification. Plant protease inhibitors exists as natural defense mechanism in plants. Solanaceous plants have highly been explored for the protease inhibitor expression and function against various insects of the order lepidoptera, coleoptera, diptera and many more. Plant protease inhibitors are the well studied class of plant defensive proteins. High level of up-regulation upon insect damage, significantly elevated levels in reproductive and storage organs as well as specificity to pest proteases ascertain their defensive function. In the present chapter, we introduced molecular basis of plant-insect interactions and focused on different classes of protease inhibitors based on their target protease(s).
Protease Inhibitors As Cancer Chemopreventive Agents
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Author : A.R. Kennedy
language : en
Publisher: Springer
Release Date : 2011-10-21
Protease Inhibitors As Cancer Chemopreventive Agents written by A.R. Kennedy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-21 with Medical categories.
Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition.
Activation Of Viruses By Host Proteases
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Author : Eva Böttcher-Friebertshäuser
language : en
Publisher: Springer
Release Date : 2018-05-22
Activation Of Viruses By Host Proteases written by Eva Böttcher-Friebertshäuser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-22 with Medical categories.
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
Handbook Of Antimicrobial Resistance
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Author : Matthias Gotte
language : en
Publisher: Springer
Release Date : 2018-02-12
Handbook Of Antimicrobial Resistance written by Matthias Gotte and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-12 with Medical categories.
While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
Nutritional And Toxicological Significance Of Enzyme Inhibitors In Foods
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Author : Mendel Friedman
language : en
Publisher: Springer
Release Date : 1986-10-31
Nutritional And Toxicological Significance Of Enzyme Inhibitors In Foods written by Mendel Friedman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-10-31 with Technology & Engineering categories.
Soybean protei ns are wi de 1 y used inhuman foods ina vari ety of forms, including baby formulas, flour, soy protein concentrates, soy protein isolates, soy sauces, textured soy fibers, and tofu. The presence of inhibitors of digestive enzymes in soy proteins impairs nutritional quality and possible safety of this impportant legume. Normal processing conditions based on the use of heat do not completely inactivate these inhibitors, so that residual amounts of plant protease inhibitors are consumed by animals and man. Inhibitors of digestive enzymes are present not only in legumes, such as soybeans, lima beans, and kidney beans, but also in nearly all plant foods, including cereals and potatoes, albeit in much smaller amounts. The antinutritional effects of inhibitors of proteolytic enzymes have been widely studied and can be ameliorated by processing and/or sulfur amino acid fortification. A more urgent concern is reports that rats fed diets containing even low levels of soybean-derived inhibitors, which are found in foods such as soy-based baby formulas, may develop over their lifespan pancreatic lesions leading eventually to neoplasia or tumor formation. On the other hand, recent stUdies suggest that certain enzyme inhibitors from plant foods may prevent cancer formation in other tissues. A key question, therefore, is whether inhibitors from plant foods constitute a human health hazard.
Principles And Practice Of Constraint Programming
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Author : Peter J. Stuckey
language : en
Publisher: Springer
Release Date : 2008-09-22
Principles And Practice Of Constraint Programming written by Peter J. Stuckey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-22 with Computers categories.
This volume contains the proceedings of the 14th International Conference on Principles and Practice of Constraint Programming (CP 2008) held in Sydney, Australia, September 14–18, 2008. The conference was held in conjunction with the International Conference on Automated Planning and Scheduling (ICAPS 2008) and the International Conference on Knowledge Representation and R- soning (KR 2008). Information about the conference can be found at the w- sitehttp://www. unimelb. edu. au/cp2008/. Held annually, the CP conference series is the premier international conference on constraint programming. The conference focuses on all aspects of computing with constraints. The CP conf- ence series is organized by the Association for Constraint Programming (ACP). Information about the conferences in the series can be found on the Web at http://www. cs. ualberta. ca/~ai/cp/. Information about ACP can be found athttp://www. a4cp. org/. CP 2008 included two calls for contributions: a call for research papers, - scribing novel contributions in the ?eld, and a call for application papers, - scribing applications of constraint technology. For the ?rst time authors could directly submit short papers for consideration by the committee. The research track received 84 long submissions and 21 short submissions and the application track received 15 long submissions. Each paper received at least three reviews, which the authors had the opportunity to see and to react to, before the papers and their reviews were discussed extensively by the members of the Program Committee.
Tactics In Contemporary Drug Design
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Author : Nicholas A. Meanwell
language : en
Publisher: Springer
Release Date : 2014-12-08
Tactics In Contemporary Drug Design written by Nicholas A. Meanwell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-08 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Proteases In Health And Disease
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Author : Sajal Chakraborti
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-04
Proteases In Health And Disease written by Sajal Chakraborti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-04 with Science categories.
In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Viral Proteases And Antiviral Protease Inhibitor Therapy
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Author : Uwe Lendeckel
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-19
Viral Proteases And Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-19 with Medical categories.
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.