Protection Of Functional Groups In Peptide Synthesis
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Protection Of Functional Groups In Peptide Synthesis
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Author : Erhard Gross
language : en
Publisher: Elsevier
Release Date : 2014-05-10
Protection Of Functional Groups In Peptide Synthesis written by Erhard Gross and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-10 with Science categories.
The Peptides: Analysis, Synthesis, Biology, Volume 3: Protection of Functional Groups in Peptide Synthesis focuses on protection of functional groups in peptide synthesis. This book consists of seven chapters. Chapter 1 reviews the large variety of amine protecting groups. The protection of carboxyl groups is described in Chapter 2, while the chemistry of sulfhydryl group protection in peptide synthesis is discussed in Chapter 3. Chapter 4 covers the protection of the hydroxyl groups of serine, threonine, tyrosine, and other hydroxyl-containing amino acids. Differential protection and selective deprotection in peptide synthesis is deliberated in Chapter 5. In chapter 6, the opportunities and constraints of the tactics of minimal protection of side-chain functions during peptide synthesis are reviewed. The last chapter is devoted to the interesting aspects of dual function groups. This volume is recommended for specialists and researchers concerned with peptide and protein research.
The Peptides Protection Of Functional Groups In Peptide Synthesis
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Author : Erhard Gross
language : en
Publisher:
Release Date : 1979
The Peptides Protection Of Functional Groups In Peptide Synthesis written by Erhard Gross and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Peptides categories.
Protection Of Functional Groups In Peptide Synthesis
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Author : Erhard Gross
language : en
Publisher:
Release Date : 1981
Protection Of Functional Groups In Peptide Synthesis written by Erhard Gross and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Peptides categories.
Protective Groups In Organic Synthesis
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Author : Theodora W. Greene
language : en
Publisher: Wiley-Interscience
Release Date : 1999-04-23
Protective Groups In Organic Synthesis written by Theodora W. Greene and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-23 with Science categories.
From the reviews of the previous editions: * "For completeness, the authors . . . include protective groups and techniques for formation and cleavage that are seldom used as well as those that are more common. . . . Anyone who does organic synthesis must have convenient access to this book." -Journal of the American Chemical Society. * "Essential to the modern synthetic organic chemist . . . should be in the libraries of all academic, governmental, and industrial organizations concerned with organic synthesis." -Polymer News. Reflecting the latest advances in protective group methodology, this Third Edition of the proven laboratory reference is expanded by more than 50%, providing readers with a comprehensive compendium of 1,050 of the most useful protective groups as well as 5,350 references to original publications. Protective groups are organized by six major organic functional groups: hydroxyl, amino, carboxyl, carbonyl, sulfhydryl, and phosphate groups (the last new to this edition). Also added in this edition are protection of the alkyne-CH, expanded coverage of protection of all groups, and many new enzymatic methods of protection and deprotection. Each chapter briefly describes the classes of available protective groups, followed by an in-depth look at the chemistry of individual protective groups, their properties, and the best methods of formation and cleavage. Ten reactivity charts with more than 28,000 entries summarize the relative reactivities of 270 commonly used protective groups with 108 reagents. This book will be an indispensable reference for synthetic chemists and students.
Greene S Protective Groups In Organic Synthesis
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Author : Peter G. M. Wuts
language : en
Publisher: John Wiley & Sons
Release Date : 2006-11-10
Greene S Protective Groups In Organic Synthesis written by Peter G. M. Wuts and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-10 with Science categories.
The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.
Protective Groups In Organic Chemistry
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Author : John Frederick William McOmie
language : en
Publisher: Springer
Release Date : 1973
Protective Groups In Organic Chemistry written by John Frederick William McOmie and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Science categories.
During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.
Protecting Groups
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Author : Philip J. Kocienski
language : en
Publisher: Thieme
Release Date : 2005
Protecting Groups written by Philip J. Kocienski and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Organic compounds categories.
The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: A critical survey of the most used protecting groups, as used by organic chemists Organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine Special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue Transformations accompanied by key experimental details Examples from the recent literature span a wide domain of organic synthesis Over 500 schemes aid visual retrieval End-of-chapter list reviews which amplify topics covered.
Chemistry Of Peptide Synthesis
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Author : N. Leo Benoiton
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Chemistry Of Peptide Synthesis written by N. Leo Benoiton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th
Side Reactions In Peptide Synthesis
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Author : Yi Yang
language : en
Publisher: Academic Press
Release Date : 2015-09-01
Side Reactions In Peptide Synthesis written by Yi Yang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Science categories.
Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration
Protecting Groups In Organic Synthesis
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Author : James Ralph Hanson
language : en
Publisher: Blackwell Science Incorporated
Release Date : 1999-01-01
Protecting Groups In Organic Synthesis written by James Ralph Hanson and has been published by Blackwell Science Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Science categories.