Protein Homology Detection Through Alignment Of Markov Random Fields
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Protein Homology Detection Through Alignment Of Markov Random Fields
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Author : Jinbo Xu
language : en
Publisher: Springer
Release Date : 2015-01-22
Protein Homology Detection Through Alignment Of Markov Random Fields written by Jinbo Xu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-22 with Computers categories.
This work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.
Modeling Protein Structure Alignment Based On Markov Random Field Theory
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Author : Xin Sheng
language : en
Publisher:
Release Date : 1999
Modeling Protein Structure Alignment Based On Markov Random Field Theory written by Xin Sheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
A Journey Through 50 Years Of Structural Bioinformatics In Memoriam Of Cyrus Chothia
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Author : Alfredo Iacoangeli
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-16
A Journey Through 50 Years Of Structural Bioinformatics In Memoriam Of Cyrus Chothia written by Alfredo Iacoangeli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-16 with Science categories.
The cover image for this Research Topic was designed by Claire Marks.
Multiple Alignments Hidden Markov Models And Svms
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Author : Mohamad Firdaus Abdullah
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012
Multiple Alignments Hidden Markov Models And Svms written by Mohamad Firdaus Abdullah and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Remote protein homology detection is a problem of detecting evolutionary relationship between proteins at low sequence similarity level. Among several problems in remote protein homology detection include the questions of determining which combination of multiple alignment and classification techniques is the best as well as the misalignment of protein sequences during the alignment process. Therefore, this study deals with remote protein homology detection via assessing the impact of using structural information on protein multiple alignments over sequence information. This study further presents the best combinations of multiple alignment and classification programs to be chosen. This study also improves the quality of the multiple alignments via integration of a refinement algorithm.
50 Years Of Statistical Physics In Mexico Development State Of The Art And Perspectives
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Author : Ramon Castañeda-Priego
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-13
50 Years Of Statistical Physics In Mexico Development State Of The Art And Perspectives written by Ramon Castañeda-Priego and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-13 with Science categories.
Research In Computational Molecular Biology
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Author : Roded Sharan
language : en
Publisher: Springer
Release Date : 2014-02-28
Research In Computational Molecular Biology written by Roded Sharan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-28 with Computers categories.
This book constitutes the refereed proceedings of the 18th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2014, held in Pittsburgh, PA, USA, in April 2014. The 35 extended abstracts were carefully reviewed and selected from 154 submissions. They report on original research in all areas of computational molecular biology and bioinformatics.
Computational Phylogenetics
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Author : Tandy Warnow
language : en
Publisher: Cambridge University Press
Release Date : 2017-11-02
Computational Phylogenetics written by Tandy Warnow and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-02 with Computers categories.
This book presents the foundations of phylogeny estimation and technical material enabling researchers to develop improved computational methods.
Homology Modeling
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Author : Sławomir Filipek
language : en
Publisher: Springer Nature
Release Date : 2023-03-23
Homology Modeling written by Sławomir Filipek and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-23 with Science categories.
This detailed volume provides state-of-the-art methodologies and reviews of important topics in the field of homology modeling. From homology modeling in the twilight zone and improving accuracy through sequence space analysis to approaches to construct multi-protein complex models, the book explores a wide variety of uses and applications of this valuable technique. Written for the highly successful Methods in Molecular Biology series, the chapters include introductions to their respective topics, lists of the necessary programs, webservers, and databases, step-by-step and readily reproducible protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Homology Modeling: Methods and Protocols serves as an ideal guide to recent homology modeling procedures, assumptions made, and model quality assessment that will illuminate the black box of homology modeling for novice readers and broaden the knowledge of this methodology for professionals.
Introduction To Data Mining For The Life Sciences
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Author : Rob Sullivan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-07
Introduction To Data Mining For The Life Sciences written by Rob Sullivan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-07 with Science categories.
Data mining provides a set of new techniques to integrate, synthesize, and analyze tdata, uncovering the hidden patterns that exist within. Traditionally, techniques such as kernel learning methods, pattern recognition, and data mining, have been the domain of researchers in areas such as artificial intelligence, but leveraging these tools, techniques, and concepts against your data asset to identify problems early, understand interactions that exist and highlight previously unrealized relationships through the combination of these different disciplines can provide significant value for the investigator and her organization.
Theoretical And Computational Methods In Genome Research
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Author : Sándor Suhai
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Theoretical And Computational Methods In Genome Research written by Sándor Suhai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The application ofcomputational methods to solve scientific and practical problems in genome research created a new interdisciplinary area that transcends boundaries tradi tionally separating genetics, biology, mathematics, physics, and computer science. Com puters have, of course, been intensively used in the field of life sciences for many years, even before genome research started, to store and analyze DNA or protein sequences; to explore and model the three-dimensional structure, the dynamics, and the function of biopolymers; to compute genetic linkage or evolutionary processes; and more. The rapid development of new molecular and genetic technologies, combined with ambitious goals to explore the structure and function ofgenomes ofhigher organisms, has generated, how ever, not only a huge and exponentially increasing body of data but also a new class of scientific questions. The nature and complexity of these questions will also require, be yond establishing a new kind ofalliance between experimental and theoretical disciplines, the development of new generations both in computer software and hardware technolo gies. New theoretical procedures, combined with powerful computational facilities, will substantially extend the horizon of problems that genome research can attack with suc cess. Many of us still feel that computational models rationalizing experimental findings in genome research fulfill their promises more slowly than desired. There is also an uncer tainty concerning the real position of a "theoretical genome research" in the network of established disciplines integrating their efforts in this field.