Protein Targeting And Translocation
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Protein Targeting And Translocation
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Author : D. A. Phoenix
language : en
Publisher: Princeton University Press
Release Date : 2014-07-14
Protein Targeting And Translocation written by D. A. Phoenix and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-14 with Science categories.
Protein targeting is a fast-moving field that has encompassed areas from biophysics to molecular biology to try to gain insight into how proteins are directed to their final functional location and how such macromolecules are able to cross semi-permeable membrane barriers during their journey. This text reviews our current state of knowledge regarding the interaction of proteins at the membrane interface and the assembly of proteins into biological membranes, before proceeding to look at targeting pathways in both prokaryotic and eukaryotic systems. The reviews have been written by some of the leading researchers in the field, with contributions from around the world and with more than 1,800 references. The text is aimed at graduate students and at researchers with an interest in protein targeting, but may also be of use to final-year undergraduates. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Protein Targeting Transport And Translocation
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Author : Ross Dalbey
language : en
Publisher: Elsevier
Release Date : 2002-04-09
Protein Targeting Transport And Translocation written by Ross Dalbey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-09 with Science categories.
Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Basic principles and techniques Targeting adn sorting sequences Protein export in bacteria Membrane protein integration into ER and bacterial membranes Protein translocation across the ER Disulfide bond formation in prokaryotes and eukaryotes Quality control in the export pathway Import of proteins into organelles The secretory pathway Vesicular transport Spectacular color throughout
Protein Targeting
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Author : Anthony Pubsley
language : en
Publisher: Academic Press
Release Date : 1989-06-28
Protein Targeting written by Anthony Pubsley and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-06-28 with Science categories.
Protein Targeting reviews different aspects of protein targeting, including similarities and differences in the pathways involved. The early stages of protein export and secretion in prokaryotes and eukaryotes are examined, along with the targeting of mitochondrial and chloroplast proteins as well as some important differences in the biogenesis of the two organelles. Comprised of nine chapters, this book begins with an overview of terminology and basic principles of protein targeting, focusing on protein traffic in eukaryotic and bacterial cells. The reader is then introduced to the basic principles and techniques of protein targeting, including protein identification and posttranslational modification. Subsequent chapters deal with the early stages in the secretory pathway; later stages in the prokaryotic and eukaryotic secretory pathways; targeting of mitochondrial, chloroplast, and peroxisomal proteins; and targeting of nuclear proteins. The book also discusses endocytosis before concluding with a description of applications of protein targeting. This monograph will be of value to scientists and biotechnologists, as well as to students of cell biology, biochemistry, microbiology, and molecular biology.
Protein Targeting To Mitochondria
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Author : F.U. Hartl
language : en
Publisher: Elsevier
Release Date : 1997-02-24
Protein Targeting To Mitochondria written by F.U. Hartl and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-24 with Science categories.
A large number of newly-synthesized polypeptides must cross one or several intracellular membranes to reach their functional locations in the eukaryotic cell. The mechanisms of protein trafficking, in particular the post-translational targeting and membrane translocation of proteins, are of fundamental biological importance and are the focus of intensive research world-wide. For more than 15 years, mitochondria have served as the paradigm organelle system to study these processes. Although key questions, such as how precisely proteins cross a membrane, still remain to be answered, exciting progress has been made in understanding the basic pathways of protein import into mitochondria and the components involved. In addition to a fascinating richness and complexity in detail, the analysis of mitochondrial protein import has revealed mechanistic principles of general significance: Major discoveries include the demonstration of the requirement of an unfolded state for translocation and of the essential role of molecular chaperones on both sides of the membranes in maintaining a translocation-competent conformation and in protein folding after import. It is becoming clear how a polypeptide chain is "reeled" across the membrane in an ATP-dependent process by the functional cooperation of membrane proteins, presumably constituting part of a transmembrane channel, with peripheral components at the trans-side of the membrane. In this volume, eminent experts in the field take the time to review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria will be discussed.
Protein Targeting And Secretion
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Author : Brian M. Austen
language : en
Publisher: IRL Press
Release Date : 1991
Protein Targeting And Secretion written by Brian M. Austen and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Protein targeting is the study of how newly synthesized proteins reach their ultimate destination. Proteins may be targeted into an intracellular organelle such as the nucleus, mitochondria, or rough endoplasmic reticulum, or they may be secreted or taken up by a cell and distributed tospecific locations such as the endosome or lysosome. Small parts of the protein's structure are recognized by intracellular receptors, which direct or 'target' the protein to its destination. Some proteins must cross membranes during this process, and many are subject to modification as they travel.The understanding of protein targeting has many applications including cancer research, the study of diseases that result from faulty targeting, and the genetic manipulation of microorganisms to target useful proteins. This volume summarizes over 20 years of research activity by the scientificcommunity into this exciting and important phenomenon. As such, it will be of value to students and researchers alike.
Protein Movement Across Membranes
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Author : Jerry Eichler
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-26
Protein Movement Across Membranes written by Jerry Eichler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-26 with Science categories.
This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems biology perspective, considered by many to be the next paradigm for biological study. Readers of this book will come away with a deeper understanding of the problems facing researchers of protein translocation and see how the most modern biological techniques and approaches are being recruited to answer those questions. The chapters are also written such that problems awaiting future investigation are clearly presented.
Targeting Signals In Protein Trafficking And Transport
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Author : Markus Kunze
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-14
Targeting Signals In Protein Trafficking And Transport written by Markus Kunze and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-14 with Science categories.
Membrane Biogenesis And Protein Targetting
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Author : W. Neupert
language : en
Publisher: Elsevier
Release Date : 1992-12-09
Membrane Biogenesis And Protein Targetting written by W. Neupert and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-12-09 with Science categories.
This book provides a comprehensive overview of recent developments in the fast moving field of protein transport across and into intracellular membranes. The soluble and membrane-bound components assisting in these processes are introduced, and their functions described. Besides a detailed analysis of protein translocation across the bacterial plasma membrane, the mechanisms of protein targeting within the eukaryotic cell are discussed with special focus on the transport of proteins to the endoplasmic reticulum, vacuoles, peroxisomes, mitochondria, and chloroplasts. Providing stimulating hypotheses and models, the book is well suited for advanced students, graduate students, and for newcomers to the field seeking a general, yet accurate introduction to present knowledge in membrane transport of proteins.
Endosymbiotic Organelle Acquisition
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Author : Steven Schwartzbach
language : en
Publisher: Springer
Release Date : 2024-06-12
Endosymbiotic Organelle Acquisition written by Steven Schwartzbach and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-12 with Science categories.
This volume provides in depth reviews of the protein targeting translocation processes, gene transfer processes and genome reduction processes in the host and in the endosymbiont which were likely utilized during the evolution of an endosymbiont into mitochondria, mitochondria related organelles, simple and complex chloroplasts. These reviews cover both the current understanding of the host processes as well as the evolutionary outcomes used by these organelles for protein targeting and translocation. Reviews of the current knowledge of these topics are plentiful but scattered throughout the bacterial, parasite, plant and animal literature; here, reviews of current knowledge with evolutionary outcomes and future perspectives, written by leading researchers in their respective areas, are united into one comprehensive volume, essential for students and scientists interested in or working onsubcellular protein localization, protein targeting signals, translocation of proteins across and insertion into membranes, nucleic acid transfer between genomes, genome reduction and evolution of mitochondria and chloroplast.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.