Protein Targeting To Mitochondria
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Protein Targeting To Mitochondria
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Author : F.U. Hartl
language : en
Publisher: Elsevier
Release Date : 1997-02-24
Protein Targeting To Mitochondria written by F.U. Hartl and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-24 with Science categories.
A large number of newly-synthesized polypeptides must cross one or several intracellular membranes to reach their functional locations in the eukaryotic cell. The mechanisms of protein trafficking, in particular the post-translational targeting and membrane translocation of proteins, are of fundamental biological importance and are the focus of intensive research world-wide. For more than 15 years, mitochondria have served as the paradigm organelle system to study these processes. Although key questions, such as how precisely proteins cross a membrane, still remain to be answered, exciting progress has been made in understanding the basic pathways of protein import into mitochondria and the components involved. In addition to a fascinating richness and complexity in detail, the analysis of mitochondrial protein import has revealed mechanistic principles of general significance: Major discoveries include the demonstration of the requirement of an unfolded state for translocation and of the essential role of molecular chaperones on both sides of the membranes in maintaining a translocation-competent conformation and in protein folding after import. It is becoming clear how a polypeptide chain is "reeled" across the membrane in an ATP-dependent process by the functional cooperation of membrane proteins, presumably constituting part of a transmembrane channel, with peripheral components at the trans-side of the membrane. In this volume, eminent experts in the field take the time to review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria will be discussed.
Protein Targeting Transport And Translocation
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Author : Ross Dalbey
language : en
Publisher: Elsevier
Release Date : 2002-04-09
Protein Targeting Transport And Translocation written by Ross Dalbey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-09 with Science categories.
Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Basic principles and techniques Targeting adn sorting sequences Protein export in bacteria Membrane protein integration into ER and bacterial membranes Protein translocation across the ER Disulfide bond formation in prokaryotes and eukaryotes Quality control in the export pathway Import of proteins into organelles The secretory pathway Vesicular transport Spectacular color throughout
Protein Targeting And Translocation
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Author : D. A. Phoenix
language : en
Publisher: Princeton University Press
Release Date : 2014-07-14
Protein Targeting And Translocation written by D. A. Phoenix and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-14 with Science categories.
Protein targeting is a fast-moving field that has encompassed areas from biophysics to molecular biology to try to gain insight into how proteins are directed to their final functional location and how such macromolecules are able to cross semi-permeable membrane barriers during their journey. This text reviews our current state of knowledge regarding the interaction of proteins at the membrane interface and the assembly of proteins into biological membranes, before proceeding to look at targeting pathways in both prokaryotic and eukaryotic systems. The reviews have been written by some of the leading researchers in the field, with contributions from around the world and with more than 1,800 references. The text is aimed at graduate students and at researchers with an interest in protein targeting, but may also be of use to final-year undergraduates. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Membrane Biogenesis And Protein Targetting
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Author : W. Neupert
language : en
Publisher: Elsevier
Release Date : 1992-12-09
Membrane Biogenesis And Protein Targetting written by W. Neupert and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-12-09 with Science categories.
This book provides a comprehensive overview of recent developments in the fast moving field of protein transport across and into intracellular membranes. The soluble and membrane-bound components assisting in these processes are introduced, and their functions described. Besides a detailed analysis of protein translocation across the bacterial plasma membrane, the mechanisms of protein targeting within the eukaryotic cell are discussed with special focus on the transport of proteins to the endoplasmic reticulum, vacuoles, peroxisomes, mitochondria, and chloroplasts. Providing stimulating hypotheses and models, the book is well suited for advanced students, graduate students, and for newcomers to the field seeking a general, yet accurate introduction to present knowledge in membrane transport of proteins.
Protein Targeting Protocols
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Author : Mark van der Giezen
language : en
Publisher: Humana Press
Release Date : 2010-10-28
Protein Targeting Protocols written by Mark van der Giezen and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Science categories.
In this updated volume, experts from around the world provide the latest protocols for isolating different organelles and the localization of particular proteins using a variety of methods such as light, confocal, and electron microscopy. Emphasis is placed on protein targeting of cellular compartments in both prokaryotic and eukaryotic systems. The book includes targeting protocols from different systems.
Endosymbiotic Organelle Acquisition
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Author : Steven Schwartzbach
language : en
Publisher: Springer
Release Date : 2024-06-12
Endosymbiotic Organelle Acquisition written by Steven Schwartzbach and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-12 with Science categories.
This volume provides in depth reviews of the protein targeting translocation processes, gene transfer processes and genome reduction processes in the host and in the endosymbiont which were likely utilized during the evolution of an endosymbiont into mitochondria, mitochondria related organelles, simple and complex chloroplasts. These reviews cover both the current understanding of the host processes as well as the evolutionary outcomes used by these organelles for protein targeting and translocation. Reviews of the current knowledge of these topics are plentiful but scattered throughout the bacterial, parasite, plant and animal literature; here, reviews of current knowledge with evolutionary outcomes and future perspectives, written by leading researchers in their respective areas, are united into one comprehensive volume, essential for students and scientists interested in or working onsubcellular protein localization, protein targeting signals, translocation of proteins across and insertion into membranes, nucleic acid transfer between genomes, genome reduction and evolution of mitochondria and chloroplast.
Plant Mitochondria
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Author : James Whelan
language : en
Publisher: Humana
Release Date : 2015-04-25
Plant Mitochondria written by James Whelan and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-25 with Science categories.
The chapters compiled in this detailed collection outline a number of methods used to study plant mitochondria today, starting from the isolation of mitochondria to detailed analyses of RNA, protein and enzymatic activities. Given that the ability to uncover mitochondria’s unique features is underpinned by current methodology, this book explores the subject from morphology to detailed molecular mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Plant Mitochondria: Methods and Protocols serves as a vital resource to beginners in the field as well as to expert researchers who find themselves being pulled into the field of mitochondrial research as it links to so many important aspects of plant cell biology.
Protein Targeting
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Author : Stella M. Hurtley
language : en
Publisher:
Release Date : 1996
Protein Targeting written by Stella M. Hurtley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Carrier proteins categories.
This volume addresses one of the fundamental problems of cell biology, namely how proteins are sent to, and maintained at, their correct destinations. Individual chapters provide up-to-date information on protein targeting to different cell organelles; the nucleus, mitochondria, peroxisomes, endoplasmic reticulum, and the Golgi complex. Topics covered include the targeting sequences that act as molecular address tags, the receptors that recognize them, and the role of molecular chaperones. Other chapters focus on how proteins are targeted to organelles that communicate with one another during membrane trafficking in the secretory and endocytic pathways.
Protein Synthesis And Targeting In Yeast
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Author : Alistair J.P. Brown
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Protein Synthesis And Targeting In Yeast written by Alistair J.P. Brown and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Due to fundamental similarities between the yeast Saccharomyces cerevisiae and multicellular organisms at the molecular level, and the powerful range of experimental tools available for this yeast, S. cerevisiae is proving an ideal model system for studies on protein synthesis and targeting. The topics covered are: - Messenger RNA stability and translation.- The translation apparatus. - Translational control andfidelity. - Protein targeting to the mitochondrion. - Nuclear transport. - The secretory pathway. - Protein folding and degradation. - Protein splicing. Modern and often novel molecular, genetic and biochemical approaches as well as most recent data are provided. The reader will gain a comprehensive view of the current status of the field.