Protein Targeting
DOWNLOAD
Download Protein Targeting PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Protein Targeting book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Protein Targeting
DOWNLOAD
Author : Anthony Pubsley
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Protein Targeting written by Anthony Pubsley and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Protein Targeting reviews different aspects of protein targeting, including similarities and differences in the pathways involved. The early stages of protein export and secretion in prokaryotes and eukaryotes are examined, along with the targeting of mitochondrial and chloroplast proteins as well as some important differences in the biogenesis of the two organelles. Comprised of nine chapters, this book begins with an overview of terminology and basic principles of protein targeting, focusing on protein traffic in eukaryotic and bacterial cells. The reader is then introduced to the basic principles and techniques of protein targeting, including protein identification and posttranslational modification. Subsequent chapters deal with the early stages in the secretory pathway; later stages in the prokaryotic and eukaryotic secretory pathways; targeting of mitochondrial, chloroplast, and peroxisomal proteins; and targeting of nuclear proteins. The book also discusses endocytosis before concluding with a description of applications of protein targeting. This monograph will be of value to scientists and biotechnologists, as well as to students of cell biology, biochemistry, microbiology, and molecular biology.
Protein Targeting Transport And Translocation
DOWNLOAD
Author : Ross Dalbey
language : en
Publisher: Elsevier
Release Date : 2002-04-09
Protein Targeting Transport And Translocation written by Ross Dalbey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-09 with Science categories.
Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Basic principles and techniques Targeting adn sorting sequences Protein export in bacteria Membrane protein integration into ER and bacterial membranes Protein translocation across the ER Disulfide bond formation in prokaryotes and eukaryotes Quality control in the export pathway Import of proteins into organelles The secretory pathway Vesicular transport Spectacular color throughout
Protein Targeting Protocols
DOWNLOAD
Author : Roger A. Clegg
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Protein Targeting Protocols written by Roger A. Clegg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
It is by no means a revelation that proteins are not uniformly distributed throughout the cell. As a result, the idea that protein molecules, because of the specificity with which they can engage in interactions with other proteins, may be aimed—via these interactions—at a restricted target, is a fundamental one in contemporary molecular life sciences. The target may be variously c- ceived as a specific molecule, a group of molecules, a structure, or a more generic type of intracellular environment. Because the concept of protein targeting is intuitive rather than expl- itly defined, it has been variously used by different groups of researchers in cell biology, biochemistry, and molecular biology. For those working in the field of intracellular signaling, an influential introduction to the topic was the seminal article by Hubbard & Cohen (TIBS [1993] 18, 172–177), which was based on the work of Cohen’s laboratory on protein phosphatases. Sub- quently, the ideas that they discussed have been further developed and extended by many workers to other key intermediaries in intracellular sign- ing, including protein kinases and a great variety of modulator and adaptor proteins.
Protein Targeting And Translocation
DOWNLOAD
Author : D. A. Phoenix
language : en
Publisher: Princeton University Press
Release Date : 2014-07-14
Protein Targeting And Translocation written by D. A. Phoenix and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-14 with Science categories.
Protein targeting is a fast-moving field that has encompassed areas from biophysics to molecular biology to try to gain insight into how proteins are directed to their final functional location and how such macromolecules are able to cross semi-permeable membrane barriers during their journey. This text reviews our current state of knowledge regarding the interaction of proteins at the membrane interface and the assembly of proteins into biological membranes, before proceeding to look at targeting pathways in both prokaryotic and eukaryotic systems. The reviews have been written by some of the leading researchers in the field, with contributions from around the world and with more than 1,800 references. The text is aimed at graduate students and at researchers with an interest in protein targeting, but may also be of use to final-year undergraduates. Originally published in 1999. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Protein Targeting To Mitochondria
DOWNLOAD
Author : F.U. Hartl
language : en
Publisher: Elsevier
Release Date : 1997-02-24
Protein Targeting To Mitochondria written by F.U. Hartl and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-24 with Science categories.
A large number of newly-synthesized polypeptides must cross one or several intracellular membranes to reach their functional locations in the eukaryotic cell. The mechanisms of protein trafficking, in particular the post-translational targeting and membrane translocation of proteins, are of fundamental biological importance and are the focus of intensive research world-wide. For more than 15 years, mitochondria have served as the paradigm organelle system to study these processes. Although key questions, such as how precisely proteins cross a membrane, still remain to be answered, exciting progress has been made in understanding the basic pathways of protein import into mitochondria and the components involved. In addition to a fascinating richness and complexity in detail, the analysis of mitochondrial protein import has revealed mechanistic principles of general significance: Major discoveries include the demonstration of the requirement of an unfolded state for translocation and of the essential role of molecular chaperones on both sides of the membranes in maintaining a translocation-competent conformation and in protein folding after import. It is becoming clear how a polypeptide chain is "reeled" across the membrane in an ATP-dependent process by the functional cooperation of membrane proteins, presumably constituting part of a transmembrane channel, with peripheral components at the trans-side of the membrane. In this volume, eminent experts in the field take the time to review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria will be discussed.
Protein Targeting With Small Molecules
DOWNLOAD
Author : Hiroyuki Osada
language : en
Publisher: John Wiley & Sons
Release Date : 2009-07-31
Protein Targeting With Small Molecules written by Hiroyuki Osada and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-31 with Science categories.
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications: Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules
Protein Targeting Compounds
DOWNLOAD
Author : Thomas Böldicke
language : en
Publisher: Springer
Release Date : 2016-05-28
Protein Targeting Compounds written by Thomas Böldicke and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-28 with Medical categories.
This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.
Protein Targeting
DOWNLOAD
Author : Anthony I. Magee
language : en
Publisher: Oxford University Press, USA
Release Date : 1992
Protein Targeting written by Anthony I. Magee and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Language Arts & Disciplines categories.
Protein Targeting And Secretion
DOWNLOAD
Author : Brian M. Austen
language : en
Publisher: IRL Press
Release Date : 1991
Protein Targeting And Secretion written by Brian M. Austen and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Protein targeting is the study of how newly synthesized proteins reach their ultimate destination. Proteins may be targeted into an intracellular organelle such as the nucleus, mitochondria, or rough endoplasmic reticulum, or they may be secreted or taken up by a cell and distributed tospecific locations such as the endosome or lysosome. Small parts of the protein's structure are recognized by intracellular receptors, which direct or 'target' the protein to its destination. Some proteins must cross membranes during this process, and many are subject to modification as they travel.The understanding of protein targeting has many applications including cancer research, the study of diseases that result from faulty targeting, and the genetic manipulation of microorganisms to target useful proteins. This volume summarizes over 20 years of research activity by the scientificcommunity into this exciting and important phenomenon. As such, it will be of value to students and researchers alike.
Protein Targeting
DOWNLOAD
Author : Stella M. Hurtley
language : en
Publisher:
Release Date : 1996
Protein Targeting written by Stella M. Hurtley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Carrier proteins categories.
This volume addresses one of the fundamental problems of cell biology, namely how proteins are sent to, and maintained at, their correct destinations. Individual chapters provide up-to-date information on protein targeting to different cell organelles; the nucleus, mitochondria, peroxisomes, endoplasmic reticulum, and the Golgi complex. Topics covered include the targeting sequences that act as molecular address tags, the receptors that recognize them, and the role of molecular chaperones. Other chapters focus on how proteins are targeted to organelles that communicate with one another during membrane trafficking in the secretory and endocytic pathways.