Proteoforms
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Proteoforms
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Author : Xianquan Zhan
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-15
Proteoforms written by Xianquan Zhan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-15 with Science categories.
A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.
Advances In Medical Imaging Detection And Diagnosis
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Author : Raj Bawa
language : en
Publisher: CRC Press
Release Date : 2023-10-18
Advances In Medical Imaging Detection And Diagnosis written by Raj Bawa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-18 with Medical categories.
Medical care is the most critical issue of our time and will be so for the foreseeable future. In this regard, the pace and sophistication of advances in medicine in the past two decades have been truly breathtaking. This has necessitated a growing need for comprehensive reference resources that highlight current issues in specific sectors of medicine. Keeping this in mind, each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various important topics in a focused area of medicine—all accomplished in a user-friendly yet interconnected format. This volume addresses advances in medical imaging, detection, and diagnostic technologies. Technological innovations in these sectors of medicine continue to provide for safer, more accurate, and faster diagnosis for patients. This translates into superior prognosis and better patient compliance, while reducing morbidity and mortality. Hence, it is imperative that practitioners stay current with these latest advances to provide the best care for nursing and clinical practices. While recognizing how expansive and multifaceted these areas of medicine are, Advances in Medical Imaging, Detection, and Diagnosis addresses crucial recent progress, integrating the knowledge and experience of experts from academia and the clinic. The multidisciplinary approach reflected makes this volume a valuable reference resource for medical practitioners, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, venture capitalists, policymakers, and biomedical researchers. A wide audience will benefit from having this volume on their bookshelf: health care systems, the pharmaceutical industry, academia, and government.
Cancer Detection And Diagnosis
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Author : Miguel Ossandon
language : en
Publisher: CRC Press
Release Date : 2025-08-21
Cancer Detection And Diagnosis written by Miguel Ossandon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-21 with Medical categories.
Emerging technologies for cancer detection and diagnosis are providing more and more advance warning of pathologies of clinical significance. Research devoted to cancers are revealing new ways of finding and treating these complex diseases. This volume reviews a broad array of new technologies for cancer detection and diagnosis. While there are several clinical books describing cancer diagnosis, and general molecular analytical technologies, these books are not focused on cancer detection and diagnosis. The aim of this book is to describe emerging cancer detection and diagnosis technologies. Key Features • Presents myriad new experimental cancer detection technologies • Describes technology so the reader may conduct similar analyses • Outlines clinical applications of technology for specific cancer and summarizes results • Discusses pitfalls and limitations, future trends and potential technological developments Miguel Ossandon has a dual background in clinical laboratory and computer science. He started working in cancer research at the Lombardi Cancer Center at Georgetown University where he also began his undergraduate training in computer science. He has been working for the National Cancer Institute since 2007. Miguel received his master’s degree at the George Washington University and PhD in computer science at the University of Maryland Baltimore County. As a program director in the Diagnostic Biomarkers and Technology Branch, he manages a grant portfolio related to computational modeling and machine learning approaches for cancer diagnosis, digital image processing/analysis, and microfluidic and circulating tumor cell technology. Ben Prickril is a former US government official working at the US National Institutes of Health, National Cancer Institute. He has a background in medically related chemistry, microbiology, immunology, patenting and intellectual property, and global health. International research development includes experience in France, Turkey, Ukraine, Czech Republic and Burkina Faso. He received his PhD from the University of Georgia. Avraham Rasooly is in the Division of Cancer Treatment and Diagnosis, National Cancer Institute. He has been responsible for developing research programs on new approaches for cancer therapy, including technologies for microbial-based cancer therapy. He received his PhD from Michigan State University.
Statistical Analysis Of Proteomics Metabolomics And Lipidomics Data Using Mass Spectrometry
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Author : Susmita Datta
language : en
Publisher: Springer
Release Date : 2016-12-15
Statistical Analysis Of Proteomics Metabolomics And Lipidomics Data Using Mass Spectrometry written by Susmita Datta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-15 with Medical categories.
This book presents an overview of computational and statistical design and analysis of mass spectrometry-based proteomics, metabolomics, and lipidomics data. This contributed volume provides an introduction to the special aspects of statistical design and analysis with mass spectrometry data for the new omic sciences. The text discusses common aspects of design and analysis between and across all (or most) forms of mass spectrometry, while also providing special examples of application with the most common forms of mass spectrometry. Also covered are applications of computational mass spectrometry not only in clinical study but also in the interpretation of omics data in plant biology studies. Omics research fields are expected to revolutionize biomolecular research by the ability to simultaneously profile many compounds within either patient blood, urine, tissue, or other biological samples. Mass spectrometry is one of the key analytical techniques used in these new omic sciences. Liquid chromatography mass spectrometry, time-of-flight data, and Fourier transform mass spectrometry are but a selection of the measurement platforms available to the modern analyst. Thus in practical proteomics or metabolomics, researchers will not only be confronted with new high dimensional data types—as opposed to the familiar data structures in more classical genomics—but also with great variation between distinct types of mass spectral measurements derived from different platforms, which may complicate analyses, comparison, and interpretation of results.
Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics
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Author : Rawi Ramautar
language : en
Publisher: John Wiley & Sons
Release Date : 2022-10-03
Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics written by Rawi Ramautar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-03 with Science categories.
Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics A powerful and essential resource for researchers with an interest in CE-MS In Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications, a team of distinguished researchers delivers a comprehensive overview of bioanalytical capillary electrophoresis coupled to mass spectrometry (CE-MS). The book explains foundational principles, technology as well the strategies and techniques used in data analysis for metabolic and proteomic studies. It also provides a global overview of recent developments and advances for improving CE-MS sensitivity and reproducibility. An essential handbook for everyone performing metabolomic and proteomic analysis, the information provided here will assist researchers in tapping into the full potential of this technique to answer biological and clinical questions. Readers will also find: A thorough introduction to the principles of capillary electrophoresis, including its fundamentals, CE separation modes, capillary coatings, and the fundamentals of mass spectrometry In-depth examinations of technological developments in capillary electrophoresis, including sample preparation, online preconcentration, detection sensitivity, and metabolic coverage Comprehensive discussions of metabolomic studies, including their biomedical and clinical applications Recent advances in proteomics, including top-down and bottom-up approaches Perfect for analytical and clinical chemists, Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications will also earn a place in the libraries of biochemists, molecular biologists, and other molecular life scientists.
Computational Methods For Predicting Post Translational Modification Sites
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Author : Dukka B. KC
language : en
Publisher: Springer Nature
Release Date : 2022-06-13
Computational Methods For Predicting Post Translational Modification Sites written by Dukka B. KC and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-13 with Science categories.
This volume describes computational approaches to predict multitudes of PTM sites. Chapters describe in depth approaches on algorithms, state-of-the-art Deep Learning based approaches, hand-crafted features, physico-chemical based features, issues related to obtaining negative training, sequence-based features, and structure-based features. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Authoritative and cutting-edge, Computational Methods for Predicting Post-Translational Modification Sites aims to be a useful guide for researchers who are interested in the field of PTM site prediction.
Processing Metabolomics And Proteomics Data With Open Software
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Author : Robert Winkler
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-03-16
Processing Metabolomics And Proteomics Data With Open Software written by Robert Winkler and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-16 with Science categories.
Metabolomics and proteomics allow deep insights into the chemistry and physiology of biological systems. This book expounds open-source programs, platforms and programming tools for analysing metabolomics and proteomics mass spectrometry data. In contrast to commercial software, open-source software is created by the academic community, which facilitates the direct interaction between users and developers and accelerates the implementation of new concepts and ideas. The first section of the book covers the basics of mass spectrometry, experimental strategies, data operations, the open-source philosophy, metabolomics, proteomics and statistics/ data mining. In the second section, active programmers and users describe available software packages. Included tutorials, datasets and code examples can be used for training and for building custom workflows. Finally, every reader is invited to participate in the open science movement.
Bioanalytics
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Author : Friedrich Lottspeich
language : en
Publisher: John Wiley & Sons
Release Date : 2018-05-29
Bioanalytics written by Friedrich Lottspeich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Science categories.
Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids. The presentation includes frequent cross-references in order to highlight the many connections between different techniques. The book provides a bird's eye view of the entire subject and enables the reader to select the most appropriate method for any given bioanalytical challenge. This makes the book a handy resource for students and researchers in setting up and evaluating experimental research. The depth of the analysis and the comprehensive nature of the coverage mean that there is also a great deal of new material, even for experienced experimentalists. The following techniques are covered in detail: - Purification and determination of proteins - Measuring enzymatic activity - Microcalorimetry - Immunoassays, affinity chromatography and other immunological methods - Cross-linking, cleavage, and chemical modification of proteins - Light microscopy, electron microscopy and atomic force microscopy - Chromatographic and electrophoretic techniques - Protein sequence and composition analysis - Mass spectrometry methods - Measuring protein-protein interactions - Biosensors - NMR and EPR of biomolecules - Electron microscopy and X-ray structure analysis - Carbohydrate and lipid analysis - Analysis of posttranslational modifications - Isolation and determination of nucleic acids - DNA hybridization techniques - Polymerase chain reaction techniques - Protein sequence and composition analysis - DNA sequence and epigenetic modification analysis - Analysis of protein-nucleic acid interactions - Analysis of sequence data - Proteomics, metabolomics, peptidomics and toponomics - Chemical biology
Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry
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Author : Ganglong Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-14
Protein Glycosylation Advances In Identification Characterization And Biological Function Elucidation Using Mass Spectrometry written by Ganglong Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-14 with Science categories.
Intracellular Mechanisms Of Synuclein Processing
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Author : Friederike Zunke
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-02
Intracellular Mechanisms Of Synuclein Processing written by Friederike Zunke and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-02 with Science categories.