Proteoforms
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Proteoforms
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Author : Xianquan Zhan
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-15
Proteoforms written by Xianquan Zhan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-15 with Science categories.
A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia.
Proteoform Identification
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Author : Liangliang Sun
language : en
Publisher: Humana
Release Date : 2023-06-18
Proteoform Identification written by Liangliang Sun and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-18 with Science categories.
This volume discusses the latest mass spectrometry (MS)-based technologies for proteoform identification, characterization, and quantification. Some of the topics covered in this book include sample preparation, proteoform separation, proteoform gas-phase fragmentation, and bioinformatics tools for MS data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Proteoform Identification: Methods and Protocols is a valuable resource for researchers in both academia and the biopharmaceutical industry who are interested in proteoform analysis using MS.
Novel Algorithms And Software For The Acquisition And Analysis Of Mass Spectrometry Based Proteomics Data
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Author : Austin Vincent Carr
language : en
Publisher:
Release Date : 2023
Novel Algorithms And Software For The Acquisition And Analysis Of Mass Spectrometry Based Proteomics Data written by Austin Vincent Carr and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Proteomics technologies enable the large-scale, high-throughput study of proteoforms inbiological systems. The foremost approach, bottom-up proteomics, can identify and quantify thousands of proteins. However, the analysis of proteoforms is hindered by the required enzymatic digestion. Top-down proteomics does not require enzymatic digestion, enabling proteoform-level analysis. The technical challenge of analyzing proteoforms has thwarted the proliferation of top-down approaches, particularly compared to the ubiquity of bottom-up proteomics. Recent advances in sample preparation have enabled the intact mass measurements of classes of proteoforms traditionally considered challenging for top-down proteomics. Consequently, key barriers to broader applicability remaining in top-down proteomics are data acquisition and data processing. An additional challenge to proteomics in general is data interpretation. Lists of thousands of quantified proteins and/or proteoforms per experiment are not interpretable without software solutions capable of converting the raw output of proteomics experiments into biologically meaningful and actionable insight. This dissertation describes software-based solutions designed to improve the acquisition, processing, and interpretation of proteomics data. Chapter 1 provides an overview of mass spectrometry and the three key challenges addressed by methods in this thesis. Chapter 2 address challenges in data acquisition by introducing automated database searching of a data independent acquisition method for top-down proteomics using a hybrid database search strategy. Chapter 3 describes a new deconvolution method for low-resolution mass spectrometry data processing, taking top-down proteomics beyond high-resolution instruments. Chapter 4 also describes improvements in top-down proteomics data processing, applying astronomical averaging with outlier rejection algorithms to mass spectrometry data. In Chapter 5, a description of the application MetaNetwork, a computer program designed to facilitate systems biology insights for proteomics data is given.
Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics
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Author : Rawi Ramautar
language : en
Publisher: John Wiley & Sons
Release Date : 2022-10-11
Capillary Electrophoresis Mass Spectrometry For Proteomics And Metabolomics written by Rawi Ramautar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-11 with Science categories.
Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics A powerful and essential resource for researchers with an interest in CE-MS In Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications, a team of distinguished researchers delivers a comprehensive overview of bioanalytical capillary electrophoresis coupled to mass spectrometry (CE-MS). The book explains foundational principles, technology as well the strategies and techniques used in data analysis for metabolic and proteomic studies. It also provides a global overview of recent developments and advances for improving CE-MS sensitivity and reproducibility. An essential handbook for everyone performing metabolomic and proteomic analysis, the information provided here will assist researchers in tapping into the full potential of this technique to answer biological and clinical questions. Readers will also find: A thorough introduction to the principles of capillary electrophoresis, including its fundamentals, CE separation modes, capillary coatings, and the fundamentals of mass spectrometry In-depth examinations of technological developments in capillary electrophoresis, including sample preparation, online preconcentration, detection sensitivity, and metabolic coverage Comprehensive discussions of metabolomic studies, including their biomedical and clinical applications Recent advances in proteomics, including top-down and bottom-up approaches Perfect for analytical and clinical chemists, Capillary Electrophoresis—Mass Spectrometry for Proteomics and Metabolomics: Principles and Applications will also earn a place in the libraries of biochemists, molecular biologists, and other molecular life scientists.
Advances In Medical Imaging Detection And Diagnosis
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Author : Raj Bawa
language : en
Publisher: CRC Press
Release Date : 2023-10-18
Advances In Medical Imaging Detection And Diagnosis written by Raj Bawa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-18 with Medical categories.
Medical care is the most critical issue of our time and will be so for the foreseeable future. In this regard, the pace and sophistication of advances in medicine in the past two decades have been truly breathtaking. This has necessitated a growing need for comprehensive reference resources that highlight current issues in specific sectors of medicine. Keeping this in mind, each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various important topics in a focused area of medicine—all accomplished in a user-friendly yet interconnected format. This volume addresses advances in medical imaging, detection, and diagnostic technologies. Technological innovations in these sectors of medicine continue to provide for safer, more accurate, and faster diagnosis for patients. This translates into superior prognosis and better patient compliance, while reducing morbidity and mortality. Hence, it is imperative that practitioners stay current with these latest advances to provide the best care for nursing and clinical practices. While recognizing how expansive and multifaceted these areas of medicine are, Advances in Medical Imaging, Detection, and Diagnosis addresses crucial recent progress, integrating the knowledge and experience of experts from academia and the clinic. The multidisciplinary approach reflected makes this volume a valuable reference resource for medical practitioners, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, venture capitalists, policymakers, and biomedical researchers. A wide audience will benefit from having this volume on their bookshelf: health care systems, the pharmaceutical industry, academia, and government.
Mass Spectrometry
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Author : Ganesh Shamrao Kamble
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-11-13
Mass Spectrometry written by Ganesh Shamrao Kamble and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-13 with Science categories.
This book provides a comprehensive overview of the emerging techniques and applications of mass spectrophotometry in various fields of sustainable chemistry. At the current level of development, the book provides "real-life" examples of analyses and applications. All the chapters are written by internationally recognized authors, and present qualitative and quantitative applications of mass spectrometry. These multidisciplined chapters cover the fundamentals as well as recent advanced analytical techniques, and offer significant information for various researchers studying biomedical, pharmaceutical, and environmental analysis.
Algorithms In Bioinformatics
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Author : Martin Frith
language : en
Publisher: Springer
Release Date : 2016-08-08
Algorithms In Bioinformatics written by Martin Frith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-08 with Computers categories.
This book constitutes the refereed proceedings of the 16th International Workshop on Algorithms in Bioinformatics, WABI 2016, held in Aarhus, Denmark. The 25 full papers together with 2 invited talks presented were carefully reviewed and selected from 54 submissions. The selected papers cover a wide range of topics from networks, tophylogenetic studies, sequence and genome analysis, comparative genomics, and mass spectrometry data analysis.
Statistical Analysis Of Proteomics Metabolomics And Lipidomics Data Using Mass Spectrometry
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Author : Susmita Datta
language : en
Publisher: Springer
Release Date : 2016-12-15
Statistical Analysis Of Proteomics Metabolomics And Lipidomics Data Using Mass Spectrometry written by Susmita Datta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-15 with Medical categories.
This book presents an overview of computational and statistical design and analysis of mass spectrometry-based proteomics, metabolomics, and lipidomics data. This contributed volume provides an introduction to the special aspects of statistical design and analysis with mass spectrometry data for the new omic sciences. The text discusses common aspects of design and analysis between and across all (or most) forms of mass spectrometry, while also providing special examples of application with the most common forms of mass spectrometry. Also covered are applications of computational mass spectrometry not only in clinical study but also in the interpretation of omics data in plant biology studies. Omics research fields are expected to revolutionize biomolecular research by the ability to simultaneously profile many compounds within either patient blood, urine, tissue, or other biological samples. Mass spectrometry is one of the key analytical techniques used in these new omic sciences. Liquid chromatography mass spectrometry, time-of-flight data, and Fourier transform mass spectrometry are but a selection of the measurement platforms available to the modern analyst. Thus in practical proteomics or metabolomics, researchers will not only be confronted with new high dimensional data types—as opposed to the familiar data structures in more classical genomics—but also with great variation between distinct types of mass spectral measurements derived from different platforms, which may complicate analyses, comparison, and interpretation of results.
Proteomics And Systems Biology
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-07-30
Proteomics And Systems Biology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-30 with Science categories.
Proteomics and Systems Biology, Volume 127 in the Advances in Protein Chemistry and Structural Biology series, outlines current proteomic methodologies and discuss the challenges in future applications of systems biology in a number of biomedical/bioscience subjects. In last few decades, advances in genomics, proteomics, metabolomics, glycomics, venomics, etc., have produced vast large-scale datasets that need to be analyzed with a single main objective of understanding biological systems as a whole. Such understanding will allow us to predict and characterize the dynamic properties of biological systems. Integrates experimental and computational methods for understanding biological systems as a whole Contains timely chapters written by well-renowned authorities in their field Includes well supported content that is accompanied by a number of high-quality illustrations, figures and tables, hence it targets a wide audience of specialists, researchers and students
Dancing Protein Clouds Intrinsically Disordered Proteins In The Norm And Pathology
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Author : Vladimir Uversky
language : en
Publisher: Academic Press
Release Date : 2019-09-15
Dancing Protein Clouds Intrinsically Disordered Proteins In The Norm And Pathology written by Vladimir Uversky and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-15 with categories.
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field