Pulmonary Immunotoxicology
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Pulmonary Immunotoxicology
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Author : Mitchell D. Cohen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pulmonary Immunotoxicology written by Mitchell D. Cohen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.
Immunotoxicology And Immunopharmacology
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Author : H Dean Jack
language : en
Publisher: CRC Press
Release Date : 1994-06-30
Immunotoxicology And Immunopharmacology written by H Dean Jack and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-30 with Medical categories.
The second edition of this text has been revised and refocused to reflect the transformation of immunotoxicology from a subdiscipline of toxicology to an independent area of research that can best be described as "environmental immunology." New chapters discuss the role of immune mediators in liver, lung, and skin toxicity, in regulating chemical- metabolizing enzymes, and in the immunosuppression produced by ultraviolet light. More emphasis is placed on the clinical consequences of immunotoxicity, as well as the interpretation of experimental data for predicting, human health risk.; The second edition is divided into three major sections: immunosuppression, autoimmunity, and hypersensitivity. This new organization of the text allows for a more thorough treatment of these phenomena, with greater attention to test methods, theoretical considerations, and clinical implications. The book includes many chapters on specific environmental agents, therapeutic drugs, biological agents, and drugs of abuse, as well as on immune-mediated toxicity in specific organ systems.
Clinical Immunotoxicology
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Author : David S Newcombe
language : en
Publisher: CRC Press
Release Date : 1992-06-30
Clinical Immunotoxicology written by David S Newcombe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-06-30 with Medical categories.
This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, describes the clinical expression of immunotoxic disorders in the lung, skin, and other target organs, offers practical guidelines for early detection and control of host defense dysfunctions, and explores strategies for assessing the short- and long-term health effects of new and old chemicals and biologicals. The book includes extensive discussions on the role of low-dose, chronic immunosuppression in cancer, as well as on specific environmental and occupational immunotoxins and immunotoxic drugs used in hematology, anesthesiology, oncology and transplantation surgery.
Biologic Markers In Immunotoxicology
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1992-02-01
Biologic Markers In Immunotoxicology written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-01 with Science categories.
Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markersâ€"sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.
Identifying And Controlling Immunotoxic Substances
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Author :
language : en
Publisher: Office of Technology Assessment
Release Date : 1991
Identifying And Controlling Immunotoxic Substances written by and has been published by Office of Technology Assessment this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Antibody-toxin conjugates categories.
Immunotoxicity Immune Dysfunction And Chronic Disease
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Author : Rodney R. Dietert
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-05
Immunotoxicity Immune Dysfunction And Chronic Disease written by Rodney R. Dietert and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-05 with Medical categories.
Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases. To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on ”Key Points” as well as “Recommendations” where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.
T Lymphocytes Subpopulations In Immunotoxicology
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Author : Ian Kimber
language : en
Publisher: John Wiley & Sons
Release Date : 1998-08-17
T Lymphocytes Subpopulations In Immunotoxicology written by Ian Kimber and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-17 with Science categories.
Den T-Lymphocyten kommt eine Schlüsselrolle im Immunsystem zu: Sie sind unter anderem für Resistenzen gegenüber Infektionen und Tumoren und für die Entwicklung von Allergien und Autoimmunität verantwortlich. Bisher gab es kein vergleichbares Buch, das Funktionen und Subpopulationen der T-Zellen wie das vorliegende Werk von immunbiologischen Grundlagen ausgehend zusammenfassend darstellt.(05/98)
Experimental Immunotoxicology
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Author : Ralph J. Smialowicz
language : en
Publisher: CRC Press
Release Date : 1996
Experimental Immunotoxicology written by Ralph J. Smialowicz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Business & Economics categories.
Immunotoxicology has emerged as a vital and expanding discipline over the past several years. Although the field of human immunotoxicology is arguably still in its infancy, a number of animal model systems have been well established and validated. Experimental Immunotoxicology provides an update on the recent advances in the field as it relates to animals and provokes discussion on approaches to the evaluation of human immunotoxicology. It is an important reference source for professionals in immunology and toxicology. The book begins with an overview of the mammalian immune system and covers the important role played by animal host susceptibility models. It also gives an update on immunotoxicolgy in sub-human primates. Vulnerability of bone marrow and the consequences of damage to immune function as well as chemical-induced immunosuppression as a consequence of exposure to chemicals are covered. Most of the chapters are organized to include a description of the profile of immunotoxicity, mechanisms of immunotoxicity, species comparisons and research needs.
Allergens And Respiratory Pollutants
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Author : Marc A. Williams
language : en
Publisher: Elsevier
Release Date : 2011-07-18
Allergens And Respiratory Pollutants written by Marc A. Williams and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-18 with Medical categories.
Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health effects of environmental exposures, immune dysfunction and inflammatory airways disease. Discusses recent advances in our understanding of cell-mediated innate immune mechanisms that occur during allergic inflammation and provides important timely coverage of diseases of concern and how such diseases are influenced by a dysfunctional immune system Provides useful information on linking environmental 'danger signals' that provoke immune dysfunction and exacerbation of existing disease Draws upon the collective expertise of an international college of leaders in the field, but also provides chapters that provide essential reference material
Allergy And Immunotoxicology In Occupational Health
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Author : Takemi Otsuki
language : en
Publisher: Springer
Release Date : 2016-10-12
Allergy And Immunotoxicology In Occupational Health written by Takemi Otsuki and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-12 with Medical categories.
This book offers a collection of the latest clinical and research findings related to allergies, one of the most frequently treated conditions in occupational medicine. The chapters not only cover asthma but also elaborate on contact dermatitis, rhinitis, and other allergic conditions, providing readers with a comprehensive overview of the substances disrupting autoimmunity and their effects on the human body. Allergy and Immunotoxicology in Occupational Health is a valuable resource for professionals and researchers in the occupational health sector, who will discover novel insights into immune effects, providing a foundation for future considerations of the health impairments caused by environmental and occupational exposure to these substances.