Purinergic Receptors And Their Modulators
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Purinergic Receptors And Their Modulators
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Author : Vittoria Colotta
language : en
Publisher: Springer Nature
Release Date : 2023-09-28
Purinergic Receptors And Their Modulators written by Vittoria Colotta and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-28 with Science categories.
This book overviews purinergic receptors that are playing key roles in human and pathophysiological processes. The book elaborates on how selective P1 and P2 modulators have been developed as therapeutics for a variety of diseases. It also provides an overview of current perspectives in the design of purinergic receptor modulators and future challenges such as the availability of selective ligands for all receptor subtypes. Divided into 12 chapters, this comprehensive volume also offers a multidisciplinary perspective on the historical evolution, starting with a chapter devoted to the roots and early discoveries of adenosine and its receptors, followed by a twenty-year retrospective on the synthesis, properties, and functional potential of adenosine receptor ligands, probes, and functional conjugates. In the next chapters, experts in the field delve into topics such as the therapeutic potential of adenosine receptor ligands in wound healing and fibrosis, the therapeutic benefits of A2A receptor antagonists, the A2B adenosine receptor as a target for brain ischemia or demyelination, the development and latest advancements in clinical trials of A3 adenosine receptor ligands. Other chapters describe bifunctional tools to study adenosine receptors, allosteric modulators of adenosine receptors, and new computational approaches to inspect adenosine receptor-ligand recognition processes. Furthermore, the book discusses the role of P2X4 receptors in immunity and inflammation. The final chapters illustrate CD73 inhibitors as antitumor agents, and bacterial ectonucleotidases as underexplored antibacterial drug targets. This book is a valuable resource for scholars working in the field of medicinal chemistry, as well as researchers in the industry, providing readers with a comprehensive understanding of adenosine receptor biology and its therapeutic potential.
P2x7 Purinergic Receptor Modulation Of Lipopolysaccharide Stimulated Macrophage Activation
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Author : Julie A. Sommer
language : en
Publisher:
Release Date : 2001
P2x7 Purinergic Receptor Modulation Of Lipopolysaccharide Stimulated Macrophage Activation written by Julie A. Sommer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Boron Based Compounds
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Author : Evamarie Hey-Hawkins
language : en
Publisher: John Wiley & Sons
Release Date : 2018-07-23
Boron Based Compounds written by Evamarie Hey-Hawkins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-23 with Science categories.
Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Voltage Gated Ca2 Channels Pharmacology Modulation And Their Role In Human Disease
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Author : Jörg Striessnig
language : en
Publisher: Springer Nature
Release Date : 2023-07-31
Voltage Gated Ca2 Channels Pharmacology Modulation And Their Role In Human Disease written by Jörg Striessnig and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with Medical categories.
The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
Pharmacological Mechanisms And The Modulation Of Pain
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-02-23
Pharmacological Mechanisms And The Modulation Of Pain written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Medical categories.
Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike. - Contains contributions from the best authors in the field of pharmacology that focus on the pharmacological mechanisms and modulation of pain - Provides an essential resource for pharmacologists, immunologists, and biochemists
Slow Synaptic Responses And Modulation
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Author : K. Kuba
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Slow Synaptic Responses And Modulation written by K. Kuba and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
Information flow as nerve impulses in neuronal circuits is regulated at synapses. The synapse is therefore a key element for information processing in the brain. Much attention has been given to fast synaptic transmission, which predominantly regulates impulse-to-impulse transmission. Slow synaptic transmission and modu lation, however, sometimes have been neglected in considering and attempting to understand brain function. Slow synaptic potentials and modulation occur with a considerable delay in response to the accumulation of synaptic and modulatory inputs. In these contexts, they are plastic in nature and play important roles in information processing in the brain. A symposium titled "Slow Synaptic Responses and Modulation" was held as the satellite symposium to the 75th Annual Meeting of the Physiological Society of Japan on March 30-31, 1998, in Kanazawa. The theme was selected not only for the reason mentioned above, but also because of the considerable involvement of many Japanese scholars in establishing the basic issues. Following the dawn of synaptic physiological research, as Sir John Eccles, Sir Bernard Katz, and Professor Stephen Kuffler carried out pioneer work, Professor Kyozou Koketsu and Professor Benjamin Libet, the students of Sir John Eccles, and their colleagues established the concept of slow synaptic responses and modulation by studying vertebrate sympathetic ganglia. Since then, the concept has been ex panded with detailed investigations of both peripheral and central synapses at the levels of single ion channels, intracellular Ca"+ dynamics, intracellular transduc tion mechanisms, and genes.
Purinergic And Beta Adrenergic Modulation Of A Voltage Gated Potassium Current In And Proliferation Of Rat Brown Adipocytes
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Author : Sean Michael Wilson
language : en
Publisher:
Release Date : 1998
Purinergic And Beta Adrenergic Modulation Of A Voltage Gated Potassium Current In And Proliferation Of Rat Brown Adipocytes written by Sean Michael Wilson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1987
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medicine categories.
Adenosine Receptors
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Author : Gyorgy Hasko
language : en
Publisher: CRC Press
Release Date : 2006-07-20
Adenosine Receptors written by Gyorgy Hasko and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-20 with Medical categories.
After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the deve
P2 Purinoceptors
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
P2 Purinoceptors written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Nature categories.
Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.