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Quasispecies Concept And Implications For Virology

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Quasispecies Concept And Implications For Virology

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Author : Esteban Domingo
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-02-19

Quasispecies Concept And Implications For Virology written by Esteban Domingo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-19 with Medical categories.

Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.

Virus As Populations

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Author : Esteban Domingo
language : en
Publisher: Academic Press
Release Date : 2019-11-06

Virus As Populations written by Esteban Domingo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-06 with Science categories.

Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. - Features current views on key steps in the origin of life and origins of viruses - Includes examples relating ancestral features of viruses with their current adaptive capacity - Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read - Considers quasispecies as a framework to understand virus adaptability and disease processes

Arenaviruses Ii

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Author : Michael B. A. Oldstone
language : en
Publisher: Springer Science & Business Media
Release Date : 2002

Arenaviruses Ii written by Michael B. A. Oldstone and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.

The second volume of Arenaviruses deals with the biology and the pathogenesis of arenaviruses primarily through the study of LCMV. The fundamental observation of MHC restriction and CD8 cytotoxic T lymphocyte killing derived initially from studies with LCMV in the mouse, and has been expanded to studies of most human pathogens, viral, bacterial, parasitic, as well as events in cancer. The scope and importance of this observation was recognized by awarding the Nobel Prize in 1996 to Rolf Zinkernagel and Peter Doherty, long-time workers in the field of LCMV and arenavirus biology. Since then, many of the principles for understanding viral pathogenesis and biology of animal viruses have been defined, in great part, from the lessons learned by studying LCMV. Those lessons and their implications are the subject of this second volume on the arenaviruses.

Quasispecies Concept And Implications For Virology

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Author : Esteban Domingo
language : en
Publisher: Springer
Release Date : 2005-12-21

Quasispecies Concept And Implications For Virology written by Esteban Domingo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-21 with Medical categories.

Viruses Essential Agents Of Life

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Author : Günther Witzany
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-13

Viruses Essential Agents Of Life written by Günther Witzany and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Science categories.

A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

Plant Virus Evolution

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Author : Marilyn J. Roossinck
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-23

Plant Virus Evolution written by Marilyn J. Roossinck and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-23 with Science categories.

This book provides a comprehensive look at the field of plant virus evolution. It is the first book ever published on the topic. Individual chapters, written by experts in the field, cover plant virus ecology, emerging viruses, plant viruses that integrate into the host genome, population biology, evolutionary mechanisms and appropriate methods for analysis. It covers RNA viruses, DNA viruses, pararetroviruses and viroids, and presents a number of thought-provoking ideas.

Quasispecies From Theory To Experimental Systems

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Author : Esteban Domingo
language : en
Publisher: Springer
Release Date : 2016-03-18

Quasispecies From Theory To Experimental Systems written by Esteban Domingo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-18 with Medical categories.

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Virus Bioinformatics

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Author : Manja Marz
language : en
Publisher: MDPI
Release Date : 2020-02-21

Virus Bioinformatics written by Manja Marz and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-21 with Science categories.

Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.

Physical Virology

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Author : Urs F. Greber
language : en
Publisher: Springer
Release Date : 2019-07-30

Physical Virology written by Urs F. Greber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-30 with Medical categories.

This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference. Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution. The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.

Principles Of Virology

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Author : S. Jane Flint
language : en
Publisher:
Release Date : 2004

Principles Of Virology written by S. Jane Flint and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.

Completely revised and updated to reflect important advances in the field, Principles of Virology, Second Edition continues to fill the gap between simple introductory texts and very advanced reviews of major virus families, introducing upper–level undergraduates, graduate students, and medical students to all aspects of virology. The second edition retains all of the defining and much–praised features of the first edition, focusing on concepts and principles and presenting a comprehensive treatment from molecular biology to pathogenesis and infection control. Written in an engagingly readable style and generously illustrated with over 400 full–color illustrations, this approachable volume offers detailed examples that illustrate common principles, specific strategies adopted by different viruses to ensure their reproduction, and the current state of virology research. The book is divided into chapters that focus on specific topics rather than individual viruses, and allows the student to visualize common themes that cut across virus families, emphasizing the shared features of different viruses. Drawing on the extensive teaching experience of each of its distinguished authors, Principles of Virology illustrates why and how animal viruses are studied and demonstrates, using well–studied systems, how the knowledge gained from such model viruses can be used to study viral systems about which our knowledge is still quite limited. A thorough introduction to principles of viral pathogenesis, a broad view of viral evolution, a discussion of how viruses were discovered, and how the discipline of virology came to be are also provided. A variety of special boxes highlight key experiments, background material, caveats, and much more. The text focuses on concepts and principles and covers not only aspects of molecular biology, but also pathogenesis, evolution, emergence, and control, and will also be a valuable resource for practicing physicians and scientists. New in the Second Edition Completely revised pathogenesis chapters Pathogenicity Snapshots: an appendix highlighting teaching points for major viral diseases Expanded appendix on viral life cycles New chapter on viral genomes and coding strategies Detailed glossary Expanded references after each chapter new textboxes

Quasispecies Concept And Implications For Virology

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