Quinolone Antibacterials
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Quinolone Antibacterials
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Author : Jochen Kuhlmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Quinolone Antibacterials written by Jochen Kuhlmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
It has been over 30 years since the first clinically important member of the quinolone class, nalidixic acid, was introduced into medical practice. The modification produced in the quinolone nucleus by introducing a fluorine at the 6-position led to the discovery of the newer fluoroquinolones with enhanced antibacterial activities as compared to nalidixic acid. By now a great deal of preclinical and clinical experience has been obtained with these agents. The intense interest in this class of antibacterial agents by chemists, micro biologists, toxicologists, pharmacologists, clinical pharmacologists, and clini cians in various disciplines encouraged us to summarize the information on the history, chemistry, mode of action and in vitro properties, kinetics and efficacy in animals, mechanisms of resistance, toxicity, clinical pharmacology, clinical experience, and future prospects in one volume of the Handbook of Experimental Pharmacology. As this series deals predominantly with "experimental" characteristics of drugs, our volume is dedicated specifically to quinolones and emphasizes principally their preclinical and clinical phar macological characteristics, despite the existence of several summaries on quinolones. The chemistry of the quinolones is described in detail. The chapter on the mode of action of quinolones reports the conclusive evidence that gyrase is the intracellular target of the quinolones; however, another enzyme, topoisomerase IV, may also be a target for quinolones, and the exact mechanisms by which quinolones act bactericidally are far from being understood.
Quinolone Antimicrobial Agents
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Author : David C. Hooper
language : en
Publisher:
Release Date : 1993
Quinolone Antimicrobial Agents written by David C. Hooper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Quinolones remain the most important class of antimicrobial agents discovered in recent years – over 1000 have been synthesized and evaluated. Since the publication of the original edition, considerable strides have been made in the research on structure–activity relationships, mechanism of action, resistance, pharmacodynamics and drug interactions. This edition consolidates and substantially updates our current state of knowledge of quinolones, with thirteen new chapters having been added.
The Quinolones
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Author : Vincent T. Andriole
language : en
Publisher: Academic Press
Release Date : 2013-10-22
The Quinolones written by Vincent T. Andriole and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with consideration of the development of resistance, pharmacology, toxicology, and clinical uses. Chemists, microbiologists, pharmacologists and clinicians will find the book useful.
Fluoroquinolone Antibiotics
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Author : Allan R. Ronald
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Fluoroquinolone Antibiotics written by Allan R. Ronald and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry.
The 4 Quinolones Anti Bacterial Agents In Vitro
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Author : Geoff C. Crumplin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The 4 Quinolones Anti Bacterial Agents In Vitro written by Geoff C. Crumplin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The 4-quinolone antibacterial agents have been under development and in use for over 25 years, but despite an enormous body of research work there are still many basic questions that remain unanswered. For example, we do not know how these agents kill susceptible cells - or even how the drugs interact with the target mol- ecule(s). However, we do know that the 4-quinolones display many properties which are not shared with any other group of antibacterial agents. This book raises the unanswered questions and assesses the potential significance to future chemotherapy of their unique features. The book also raises matters which are significant for physicians as well as for the pharmaceutical industry and the assessment of these agents by legislative bodies concerned with drug safety.
Quinolone Antimicrobial Agents
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Author : David C. Hooper
language : en
Publisher:
Release Date : 2003
Quinolone Antimicrobial Agents written by David C. Hooper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Bacterial diseases categories.
Fluoroquinolone Antibiotics Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Fluoroquinolone Antibiotics Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Fluoroquinolone Antibiotics in a concise format. The editors have built Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Fluoroquinolone Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fluoroquinolone Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Quinolones In Pulmonary Tuberculosis Management
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Author : Len J. LaScolea
language : en
Publisher: CRC Press
Release Date : 1996-04-16
Quinolones In Pulmonary Tuberculosis Management written by Len J. LaScolea and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-16 with Medical categories.
This state-of-the-art reference provides detailed information on the use of quinolone antibiotics and other antibiotic regimens in the management of pulmonary tuberculosis-offering in-depth coverage of the history, epidemiology, clinical presentation, diagnosis, immunopathology, and immunotherapy of tuberculosis for the nonspecialist. Covering all major topics related to tuberculosis infection, Quinolones in Pulmonary Tuberculosis Management discusses tuberculosis therapies for various patient populations such as AIDS patients, children, pregnant women, and the elderly examines initial drug regimens to treat tuberculosis presents specific information on how to deal with multiple drug-resistant tuberculosis evaluates the tuberculosis skin test analyzes how to reduce the spread of tuberculosis in hospitals assesses the effectiveness of combination formulations for the management of tuberculosis and more!
The New Generation Of Quinolones
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Author : Siporin
language : en
Publisher: CRC Press
Release Date : 1990-08-28
The New Generation Of Quinolones written by Siporin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-08-28 with Medical categories.
Surveys the newest members of a family of antimicrobial drugs increasingly being used to treat infections of the urinary tract, lungs, skin, bones, and diarrheal diseases. The drugs have been developed only since the 1960s, and still pose many questions about resistance and toxic and developmental s
Antibiotics Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Antibiotics Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Antibiotics: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Antibiotics in a concise format. The editors have built Antibiotics: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antibiotics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antibiotics: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.