Radiation And The Immune System Current Knowledge And Future Perspectives
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Radiation And The Immune System Current Knowledge And Future Perspectives
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Author : Katalin Lumniczky
language : en
Publisher: Frontiers Media SA
Release Date : 2018-05-03
Radiation And The Immune System Current Knowledge And Future Perspectives written by Katalin Lumniczky and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-03 with categories.
For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent.
Ionizing Radiation And The Immune Response Part A
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-03-29
Ionizing Radiation And The Immune Response Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-29 with Science categories.
Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flashtherapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and more. Additional sections touch on the Effect of low dose radiation on radio-induced immune response, Role of Dendritic cells in radiation-induced immune response, Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunotherapy combination+A23, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination. - Covers the latest insights on the biological and physical parameters that modulate radio-induced immune response - Provides an accurate review by selected experts of the impact on the immune response of new techniques delivering ionizing radiations - Presents valuable information to clinicians to optimize radiotherapy and immunotherapy combinations
Women In Cancer Immunity And Immunotherapy
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Author : Adriana Albini
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-30
Women In Cancer Immunity And Immunotherapy written by Adriana Albini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-30 with Medical categories.
At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. Therefore, Frontiers in Immunology is proud to offer this platform to promote the work of women scientists, across all fields of Cancer Immunity and Immunotherapy.
Modeling For Prediction Of Radiation Induced Toxicity To Improve Therapeutic Ratio In The Modern Radiation Therapy Era
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Author : Ester Orlandi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-27
Modeling For Prediction Of Radiation Induced Toxicity To Improve Therapeutic Ratio In The Modern Radiation Therapy Era written by Ester Orlandi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-27 with Medical categories.
Redox Biology In Plasma Medicine
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Author : Sander Bekeschus
language : en
Publisher: CRC Press
Release Date : 2024-07-12
Redox Biology In Plasma Medicine written by Sander Bekeschus and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-12 with Medical categories.
Plasma medicine uses non-equilibrium plasmas generated under atmospheric-pressure conditions. Therapeutical plasmas can stimulate tissue regeneration or inactivate cancer cells. This book reviews the interrelation between plasma chemistry and biochemistry complemented by discussion of the ways plasmas inactivate various pathogens. Focus is on the plasma effects on mammalian cells, subsequent consequences for cell-biological processes, and plasma applicability specific medical therapies. Contributions illustrate the ways cold atmospheric-pressure plasma can be used as a controllable source of redox-active species and as a useful tool for research in redox biology. Key Features Summarizes plasma chemistry, biochemistry, and microbiology Documents the ways plasmas interact with lipids, membranes, and cells Reviews therapeutic uses of plasmas in medicine Focuses on uses of plasmas as cancer treatment
Translational Research In Cardio Oncology An Issue Of Heart Failure Clinics
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Author : Ragavendra R. Baliga
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-06-23
Translational Research In Cardio Oncology An Issue Of Heart Failure Clinics written by Ragavendra R. Baliga and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-23 with Medical categories.
In this issue of Heart Failure Clinics, guest editors Drs. Ragavendra R Baliga and George A. Mensah bring their considerable expertise to the topic of Translational Research in Cardio-Oncology. Top experts in the field cover key topics such as radiation-induced cardiac dysfunction; training and career development; cardiovascular imaging; CAR-T cell therapy and cardiovascular disease; and more. - Contains 12 relevant, practice-oriented topics including cardio-protection of high-risk individuals; myocardial metabolism; amyloidosis; arrhythmic complications associated with cancer therapies; and more. - Provides in-depth clinical reviews on translational research in cardio-oncology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Ionizing Radiation Reprograms Tumor Immune Microenvironment By Inducing Immunogenic Cell Death
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Author : Fei Yu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-25
Ionizing Radiation Reprograms Tumor Immune Microenvironment By Inducing Immunogenic Cell Death written by Fei Yu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-25 with Medical categories.
Food Process Engineering And Technology
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Author : Junaid Ahmad Malik
language : en
Publisher: Springer Nature
Release Date : 2024-01-05
Food Process Engineering And Technology written by Junaid Ahmad Malik and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-05 with Technology & Engineering categories.
This book focuses on novel technologies related to food processing technology and engineering. It also focuses on food safety, quality and management, the scope of the Internet of Things (IoT) in food processing and its management, bioengineering tools for crop improvement in agriculture, recent innovations in food packaging, nanotechnology in food processing, and the nutritional health benefits of food. 3D printed food, an interesting and increasingly popular concept among the public today, is a meal prepared through an automated additive process using 3D food printers. This book is a ready reference for food researchers, students, and industry professionals. The book updates the current scenario of food processing technology and engineering for readers from agriculture and its allied fields including students and researchers of food science and technology, dairy science and technology, packaging industry, people working in food safety organisations, and researchers in the field of nanotechnology.
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy
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Author : Patrik Andersson
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy written by Patrik Andersson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Radiation Induced Effects And The Immune System
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Author : Gabriele Multhoff
language : en
Publisher: Frontiers E-books
Release Date :
Radiation Induced Effects And The Immune System written by Gabriele Multhoff and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Numerous developments in molecular biology have led to an explosive growth in the knowledge underlying mechanisms of carcinogenesis, cell signalling, tumor progression and development of metastasis. However, cure of cancer is still hampered by the inherited capacity of tumors to become resistant to standard therapies, to metastasize from their initial location and to proliferate in other tissue compartments. Radiotherapy is one of the main treatment modalities to achieve locoregional tumor control. However, the treatment of distant metastases further remains to be a challenge. In this special topic we are interested to elucidate immunological aspects which are initiated and affected by radiotherapy. We also aim to describe the development of innovative immunological strategies from a preclinical stage to clinical application which could be combined with standard radiotherapeutic approaches. A special interest will also deal with the effects of radiotherapy on tumor initiating cells as well as on the tumor microenvironment. Last but not least the effects of different irradiation sources and qualities such as photones, protones and heavy ions will be analyzed with respect to immunological outcome.