Regulatory Non Coding Rnas
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Regulatory Non Coding Rnas
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Author : Anna Robinson
language : en
Publisher: Syrawood Publishing House
Release Date : 2023-09-19
Regulatory Non Coding Rnas written by Anna Robinson and has been published by Syrawood Publishing House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Science categories.
Non coding RNAs (ncRNAs) consist of a large portion of poly-A tailed mature RNAs. They are single stranded molecules, which are involved in the regulation of gene expression at the post-transcriptional level in a cell. There are two types of ncRNAs, which are regulatory ncRNAs and infrastructural ncRNAs. Small interfering RNAs (siRNAs), microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and piwi-interacting RNAs (piRNAs) are the four types of regulatory ncRNAs. The expression of thousands of genes is regulated through ncRNAs and this regulation can take place in either cis or trans. NcRNAs must be integrated into regulatory networks for the identification of molecular driver events. The two largest members of the ncRNA family, which includes long non coding RNA (lncRNA) and micro RNA (miRNA), play significant regulatory roles in gene expression. They are also involved in a variety of physiological processes including programmed cell death. This book unravels the recent studies on non coding RNA biology. It attempts to understand the regulation of non coding RNAs. For all those who are interested in ncRNAs, it can prove to be an essential guide.
Regulatory Non Coding Rnas
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Author : Gordon G. Carmichael
language : en
Publisher: Humana Press
Release Date : 2014-09-20
Regulatory Non Coding Rnas written by Gordon G. Carmichael and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-20 with Medical categories.
Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.
Regulatory Rnas
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Author : Bibekanand Mallick
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-01
Regulatory Rnas written by Bibekanand Mallick and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-01 with Science categories.
Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
Navigating Non Coding Rna
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Author : Joanna Sztuba-Solinska
language : en
Publisher: Elsevier
Release Date : 2023-06-17
Navigating Non Coding Rna written by Joanna Sztuba-Solinska and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-17 with Science categories.
Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies Explores the molecular mechanisms and intermolecular interactions of ncRNA
Non Coding Rnas
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Author : Jan Barciszewski
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-08-31
Non Coding Rnas written by Jan Barciszewski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-31 with Science categories.
General inspection of a role performed in the cell by RNAs allows us to distinguish three major groups of transcripts: I. protein-coding mRNAs, II. non-coding housekeeping and III. regulatory RNAs. The housekeeping RNAs include RNA classes that are generally, constitutively expressed and whose presence is required for normal function and viability of the cells. On the other hand, a group of regulatory RNAs includes RNA species that are expressed at certain stages of organism development or cell differentiation or as a response to external stimuli and can affect expression of other genes on the levels of transcription or translation. Non-coding RNA transcripts form a heterogeneous class of RNAs that can not be characterized by a single specific function. Initially, the term non-coding RNA (ncRNA) was used primarily to describe polyadenylated and a capped eukaryotic RNAs transcribed by RNA polymerase II, but lacking long open reading frames. Now, this definition can be extended to cover all RNA transcripts that do not show protein-coding capacity and is sometimes used to describe any RNA that does not encode protein, including introns. This book is an in-depth look at the function of Non-Coding RNAs and their relationship to Molecular Biology and Molecular Biology.
Regulatory Rnas
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Author : Bibekanand Mallick
language : en
Publisher: Springer
Release Date : 2012-02-05
Regulatory Rnas written by Bibekanand Mallick and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-05 with Science categories.
Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.
Regulatory Non Coding Rnas
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Author : Gordon G. Carmichael
language : en
Publisher: Humana Press
Release Date : 2014-09-20
Regulatory Non Coding Rnas written by Gordon G. Carmichael and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-20 with Medical categories.
Regulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.
Non Coding Rnas And Epigenetic Regulation Of Gene Expression
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Author : Kevin V. Morris
language : en
Publisher: Caister Academic Press Limited
Release Date : 2012
Non Coding Rnas And Epigenetic Regulation Of Gene Expression written by Kevin V. Morris and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Epigenesis categories.
Non-coding RNAs potentially play an active role in modulating gene transcription and epigenetic states. Several genes in differentiated cells may be under some form of RNA-based transcriptional and epigenetic regulatory control. This form of regulation may be controlled by selective pressures and influence the adaptability of the cell. The concept that RNA can control epigenetic states impacts our understanding of the basic fabric of the cell and may have therapeutic potential. Many studies have been carried out on the modulation of gene transcription by non-coding RNAs. This book, written by a group of distinguished scientists, represents an important overview and summary of the field to date. The 13 chapters are organized into three sections: a) Non-coding RNAs: Form, Function and Diversity; b) Non-coding RNAs: Gene Regulation and Epigenetics; and c) Non-coding RNAs: Disease and Therapeutics. This up-to-date volume is an essential book for those working in the area and represents a major information resource on current research in the fast-moving fields of epigenetics, the regulation of gene expression, and RNA research.
Molecular Biology Of Long Non Coding Rnas
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Author : Ahmad M. Khalil
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-20
Molecular Biology Of Long Non Coding Rnas written by Ahmad M. Khalil and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-20 with Medical categories.
Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.
Ago Driven Non Coding Rnas
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Author : Bibekanand Mallick
language : en
Publisher: Academic Press
Release Date : 2019-01-20
Ago Driven Non Coding Rnas written by Bibekanand Mallick and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-20 with Science categories.
The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy