Retinal Changes In Neurological Diseases
DOWNLOAD
Download Retinal Changes In Neurological Diseases PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Retinal Changes In Neurological Diseases book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Retinal Changes In Neurological Diseases
DOWNLOAD
Author : Yuyi You
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-23
Retinal Changes In Neurological Diseases written by Yuyi You and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-23 with Science categories.
Behold The Eye In Parkinson S Disease Alzheimer S Disease
DOWNLOAD
Author : Ivan Bodis-Wollner
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-20
Behold The Eye In Parkinson S Disease Alzheimer S Disease written by Ivan Bodis-Wollner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-20 with categories.
There are increasing lines of evidence showing that neurodegeneration in Alzheimer’s disease (AD) and Parkinson’s disease (PD) is not limited to the brain but also occurs in the retina. Consequently, AD/PD patients can gradually develop vision problems. This neurological and ophthalmological disorder creates a pressing need for developing therapy to treat vision impairment in AD/PD. On the other hand, pathophysiological changes in the retina may reflect what might happen in the same diseases in the brain. Thus retinal studies may allow us to develop quantifiable measures for the diagnosis and prognosis of disease progression. Furthermore, parallel or early pathophysiological changes of the retina in AD/PD allow us to study retina-brain interactions.
Oct And Imaging In Central Nervous System Diseases
DOWNLOAD
Author : Andrzej Grzybowski
language : en
Publisher: Springer Nature
Release Date : 2020-01-01
Oct And Imaging In Central Nervous System Diseases written by Andrzej Grzybowski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-01 with Medical categories.
The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.
Brain Vs Retina Differences And Commonalities The Role Of Oxidative Stress In Neurodegenerative Diseases
DOWNLOAD
Author : Jose Hurst
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-15
Brain Vs Retina Differences And Commonalities The Role Of Oxidative Stress In Neurodegenerative Diseases written by Jose Hurst and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-15 with Science categories.
Oxidative stress, free radicals, antioxidants - when it comes to our health, this topic is taking up more and more attention. But what is oxidative stress, how does it arise and what effects does it have on the most sensitive area of our body: the neuronal tissue or the retina. Many neurological diseases affecting the brain or the retina are associated with elevated levels of reactive oxygen species (ROS). High levels of ROS can cause damage to proteins, nucleic acids, lipids, membranes, and organelles such as mitochondria, and can be caused not only by external stimuli but also by aging. Most theories on the aging scenario assume that cumulative oxidative stress leads to mitochondrial changes, mitochondrial dysfunction, and oxidative damage. Therefore, it is not surprising that excess ROS is among others associated with the development of a variety of age-related neuronal diseases, including Alzheimer's and Parkinson's disease, as well as retinal diseases diabetic retinopathy, glaucoma, and age-related macular (AMD) degeneration. The aim of this Research Topic is to answer open questions, to combine already gained knowledge, to close the gaps between ophthalmology and neurology when it comes to oxidative stress in order to understand the underlying pathways and derive innovative therapies. It searches for the updates and new findings in both fields that answer the central question: are the same cell types affected by oxidative stress in the same way in the brain and retina? Experimental studies or patient studies that provide new insights are welcome, as well as studies that investigate antioxidant therapies.
Seeing Beyond The Eye The Brain Connection
DOWNLOAD
Author : Christine Nguyen
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-02
Seeing Beyond The Eye The Brain Connection written by Christine Nguyen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-02 with Science categories.
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders
DOWNLOAD
Author : Aasef G. Shaikh
language : en
Publisher: Frontiers Media SA
Release Date : 2018-08-29
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders written by Aasef G. Shaikh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with categories.
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.
Aspects Of Retinal And Optic Nerve Pathology After Excitotoxic Retinal Injury
DOWNLOAD
Author : Sarabjit Kaur Saggu
language : en
Publisher:
Release Date : 2011
Aspects Of Retinal And Optic Nerve Pathology After Excitotoxic Retinal Injury written by Sarabjit Kaur Saggu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Neurotoxicology categories.
A large body of evidence supports the notion that excitotoxicity plays a major role in the pathogenesis of a number of neurological diseases, including central nervous system (CNS) ischaemia, Alzheimer's disease, motor neurone disease, and glaucoma. In the global population 60 years of age and over, these diseases are among the leading causes of mortality and morbidity. Although the site of excitotoxic injury is principally at the level of the cell body (perikaryal), understanding the secondary effects on the neuronal axon is important because axonopathy is a documented early feature of these common neurological conditions; hence, an understanding of the pattern and mechanisms of secondary axonal degeneration after excitotoxic perikaryal injury could provide novel detection and treatment strategies in the early phase of neurological disease. The retina and optic nerve, as approachable regions of the CNS, provide a unique anatomical substrate to investigate axonal degeneration after perikaryal excitotoxic injury. Spatiotemporal changes in the retina and optic nerve were studied after injection of 20nM of Nmethyl-D-Aspartate (NMDA) in the left eye of the rat with the saline-injected right eye serving as the control. Temporal changes in the morphology of retina and optic nerve were studied by light and electron microscopy. Progressive retinal damage beginning at 72 hrs, seen as thinning of the inner retina and cell loss in the ganglion cell layer, showed strong correlation (R= 0.949) with degenerative changes in the optic nerve; the distal optic nerve segment displayed significantly more axon loss, axon swellings and myelin damage than the proximal segment (p
Neuroscience Biomarkers And Biosignatures
DOWNLOAD
Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2008-01-08
Neuroscience Biomarkers And Biosignatures written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Medical categories.
Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2018
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.
Neurodegeneration And Neuroprotection In Retinal Disease
DOWNLOAD
Author : Giovanni Casini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-21
Neurodegeneration And Neuroprotection In Retinal Disease written by Giovanni Casini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-21 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.