Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption

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Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption

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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2018-09-03

Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with categories.

This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.

Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption

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Author : Organisation for Economic Co-operation and Development (OECD)
language : en
Publisher:
Release Date : 2018

Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption written by Organisation for Economic Co-operation and Development (OECD) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Endocrine disrupting chemicals categories.

This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. The document is intended to provide guidance for evaluating chemical using standardised test guidelines. Specific objectives include providing a description of the OECD conceptual framework for evaluating chemicals for endocrine disruption, background on the standardised test methods used, and guidance for interpreting the outcome of individual tests. The general approach taken by the document is primarily to provide guidance on how test results might be interpreted based on the outcome of standardised assays. Key questions addressed in the document concern likely mechanisms of endocrine action and any resulting apical effects that can be attributed to such action. The document is not proscriptive but provides suggestions for possible next steps in testing (if any) which might be appropriate for a regulatory authority to take, given the various data scenarios. The guidance document is focused primarily on endocrine modalities included in the conceptual framework; estrogen, androgen, and thyroid mediated endocrine disruption and chemicals that interfer with steroidogenesis.

Oecd Studies On Water Endocrine Disrupting Chemicals In Freshwater Monitoring And Regulating Water Quality

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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2023-10-12

Oecd Studies On Water Endocrine Disrupting Chemicals In Freshwater Monitoring And Regulating Water Quality written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with categories.

Endocrine disrupting chemicals (EDCs) are contaminants of emerging environmental and health concern that have been detected in freshwater, wastewater and drinking water. They interfere with the endocrine system in humans and wildlife, and produce adverse effects such as developmental, reproductive, neurological and immune effects.

Challenges In Endocrine Disruptor Toxicology And Risk Assessment

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Author : Alberto Mantovani
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-08

Challenges In Endocrine Disruptor Toxicology And Risk Assessment written by Alberto Mantovani and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Science categories.

Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Endocrine Disruption And Human Health

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Author : Philippa D. Darbre
language : en
Publisher: Academic Press
Release Date : 2021-09-19

Endocrine Disruption And Human Health written by Philippa D. Darbre and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-19 with Medical categories.

**Selected for Doody's Core Titles® 2024 in Endocrinology/Metabolic Disease** Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations - Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology

Saving Costs In Chemicals Management How The Oecd Ensures Benefits To Society

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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-01-28

Saving Costs In Chemicals Management How The Oecd Ensures Benefits To Society written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with categories.

The chemical industry is one of the largest industrial sectors in the world and is expected to grow fourfold by 2060. Indeed modern life without chemicals would be inconceivable. Given the potential environmental and human health risks from exposure to chemicals, governments and industry have a ...

Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 251 Rapid Androgen Disruption Activity Reporter Radar Assay

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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2022-06-30

Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 251 Rapid Androgen Disruption Activity Reporter Radar Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with categories.

The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.

Toxicology For The Health And Pharmaceutical Sciences

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Author : Antonio Peña-Fernández
language : en
Publisher: CRC Press
Release Date : 2021-12-21

Toxicology For The Health And Pharmaceutical Sciences written by Antonio Peña-Fernández and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-21 with Medical categories.

There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.

Who Human Health Risk Assessment Toolkit

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2021-09-30

Who Human Health Risk Assessment Toolkit written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with History categories.

Handbook Of Laboratory Animal Science

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Author : Jann Hau
language : en
Publisher: CRC Press
Release Date : 2021-05-17

Handbook Of Laboratory Animal Science written by Jann Hau and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-17 with Medical categories.

Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.