Rnai
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Rnai Technology
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Author : R. K. Gaur
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Rnai Technology written by R. K. Gaur and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Science categories.
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Rnai
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Author : Gregory J. Hannon
language : en
Publisher: CSHL Press
Release Date : 2003
Rnai written by Gregory J. Hannon and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Gene silencing categories.
In the past three years, the use of double-stranded RNA to silence gene activity has become widely and rapidly adopted. RNA interference is highly specific and remarkably potent, and it acts on cells and tissues far removed from the site of introduction. The principles behind RNAi are just being uncovered, but this laboratory technique has been applied effectively in a wide variety of animal and plant species. Variations on RNAi are revolutionizing many approaches to experimental biology, complementing traditional genetic technologies with a quicker and less expensive way of mimicking the effects of mutations both in cell cultures and in living animals. Recent advances in the use of RNAi to engineer heritable silencing in mammals, to alter stem cells for organ reconstitution, and to alter the course of disease in model systems indicate that RNAi may have a future in disease therapy. Written by pioneers in this new field and edited by Gregory Hannon, one of its leading figures, RNAi: A Guide to Gene Silencing presents the principles of RNAi and reliable protocols for its laboratory use in Caenorhabditis elegans, Drosophila, plants, avian embryos, mammalian cells, mouse oocytes, and more. This important and unique book is an essential laboratory resource for scientists studying gene regulation and for all experimental biologists interested in the emerging practical applications of RNAi.
Rnai
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Author : Martin Latterich
language : en
Publisher: Garland Science
Release Date : 2008-09-04
Rnai written by Martin Latterich and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-04 with Science categories.
One of the major recent discoveries in molecular and cellular biology is that small double-stranded RNA molecules selectively turn off gene expression in all types of cell, a phenomenon known as RNA silencing. This discovery led to the development of RNA interference (known as RNAi) as a powerful research tool in the functional study of individual genes and their products, and in functional genomics. In RNAi, specific small double-stranded RNA molecules (small interfering RNAs or siRNAs) are introduced into cells to selectively silence certain genes. RNAi covers the basic concepts and mechanisms of RNAi, transfection of cells with siRNAs, the design and validation of RNAi reagents, RNAi techniques in different organisms, large-scale RNAi screening, applications of RNAi in drug discovery, and potential uses of RNAi as a therapeutic agent. A key feature of RNAi is the highlighting of the pitfalls that can occur and how to minimize them. The book also contains a complete list of abbreviations.
Rna Interference
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Author : David R. Engelke
language : en
Publisher: Elsevier
Release Date : 2005-02-28
Rna Interference written by David R. Engelke and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-02-28 with Science categories.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences. RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and prospects as a human therapy agent. * One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences
Advanced Delivery And Therapeutic Applications Of Rnai
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Author : Kun Cheng
language : en
Publisher: John Wiley & Sons
Release Date : 2013-04-19
Advanced Delivery And Therapeutic Applications Of Rnai written by Kun Cheng and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-19 with Science categories.
Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.
Rna Interference Rnai
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Author : Wiley
language : en
Publisher: John Wiley & Sons
Release Date : 2013-11-26
Rna Interference Rnai written by Wiley and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-26 with Science categories.
The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) molecules. This collection of articles begins with an introduction to RNAi, and proceeds to describe uses of this technology in various approaches to disease treatment, including gene therapy. Several laboratory protocols for silencing genes via RNAi are also provided, as are protocols for down-regulating and then rescuing those down-regulated genes, which demonstrates specificity of the approach. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of RNA interference for students or interdisciplinary collaborators.
Rna Interference
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Author : Dr. Tim Doran
language : en
Publisher: CABI
Release Date : 2009
Rna Interference written by Dr. Tim Doran and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
This methods manual provides an introduction to RNA interference, the theory behind its many applications, and specific protocols for RNAi, in organisms from plants and C.elegans to Drosophila and mammals. There are also chapters covering small hairpin RNAs and viral-induced gene silencing.
Rna Technologies And Their Applications
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Author : Volker A. Erdmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-02
Rna Technologies And Their Applications written by Volker A. Erdmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-02 with Medical categories.
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Rnai Technologies
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Author : Prerna Pandey
language : en
Publisher: Delve Publishing
Release Date : 2017-11
Rnai Technologies written by Prerna Pandey and has been published by Delve Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11 with Gene silencing categories.
RNA interference (RNAi), one of the most exciting discoveries of the last decade, is also known as Post-Transcriptional Gene Silencing (PTGS). It is a conserved host defense response via double-stranded RNA against both endogenous and foreign nucleic acids, and occurs at the levels of transcription, post-transcription and translation. RNA induced gene silencing has been used, with considerable success as a reverse genetics tool for the study of gene function. This technology has revolutionized the gene expression analysis studies because of the specificity and speed it offers. The small RNA molecules central to RNAi are microRNA (miRNA) and small interfering RNA (siRNA). These molecules bind to other RNAs specifically, such as messenger RNA (mRNA), to regulate their activities.In this book, we will discuss how gene silencing methodology has been successfully applied as therapeutic tool against metabolic disorders, cancer, and infectious diseases. This tool has also been successfully used to improve crops resistance against plant pathogens. In contrast to conventional knock-out mutagenesis techniques, the "gene-silencing" vectors, that allow the study of functions of genes whose complete knock-out would otherwise be lethal to the plant.
Rna Interference Technology
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2005-01-17
Rna Interference Technology written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-17 with Science categories.
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.