Scientific Criteria For Validation Of In Vitro Toxicity Tests
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Scientific Criteria For Validation Of In Vitro Toxicity Tests
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Author : John M. Frazier
language : en
Publisher:
Release Date : 1990
Scientific Criteria For Validation Of In Vitro Toxicity Tests written by John M. Frazier and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Environmental protection categories.
In Vitro Toxicology Second Edition
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Author : Shayne C. Gad
language : en
Publisher: CRC Press
Release Date : 2000-11-02
In Vitro Toxicology Second Edition written by Shayne C. Gad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-02 with Medical categories.
Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
Environmental Health Perspectives
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Author :
language : en
Publisher:
Release Date : 1993
Environmental Health Perspectives written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Environmental health categories.
Alternative Testing Methodologies
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Author :
language : en
Publisher:
Release Date : 1998
Alternative Testing Methodologies written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Principles And Methods Of Toxicology Fifth Edition
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2007-09-25
Principles And Methods Of Toxicology Fifth Edition written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.
Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Toxicological Principles For The Safety Assessment Of Direct Food Additives And Color Additives Used In Food
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Author :
language : en
Publisher:
Release Date : 1993
Toxicological Principles For The Safety Assessment Of Direct Food Additives And Color Additives Used In Food written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Coloring matter in food categories.
The History Of Alternative Test Methods In Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-20
The History Of Alternative Test Methods In Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-20 with Medical categories.
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Modulation Of Cellular Responses In Toxicity
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Author : Corrado L. Galli
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Modulation Of Cellular Responses In Toxicity written by Corrado L. Galli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Proceedings of the NATO Advanced Study Institute on the Modulation of Cellular Response in Toxicity, held in Ponte di Legno, Italy , January 24 - February 3, 1994.
Alternatives To The Use Of Live Vertebrates In Biomedical Research And Testing
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Author :
language : en
Publisher:
Release Date : 1991
Alternatives To The Use Of Live Vertebrates In Biomedical Research And Testing written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Animal experimentation categories.
Alternative Methodologies For The Safety Evaluation Of Chemicals In The Cosmetic Industry
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Author : Nicola Loprieno
language : en
Publisher: CRC Press
Release Date : 2019-08-15
Alternative Methodologies For The Safety Evaluation Of Chemicals In The Cosmetic Industry written by Nicola Loprieno and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-15 with Medical categories.
First published in 1995: Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry presents a categorization and collection of information available for the evaluation of safety using in vitro techniques. It offers a comprehensive and complete look at the entire field. In doing so, the author provides the foundation for the next phase of significant growth for this discipline.