Single Cell Omics Analyses In Cardiovascular Diseases
DOWNLOAD
Download Single Cell Omics Analyses In Cardiovascular Diseases PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Single Cell Omics Analyses In Cardiovascular Diseases book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Single Cell Omics Analyses In Cardiovascular Diseases
DOWNLOAD
Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-14
Single Cell Omics Analyses In Cardiovascular Diseases written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-14 with Medical categories.
Single-cell OMICs analyses have recently become one of the most promising tools to probe biology at the cellular level, in large part due to its ability to address issues beyond the bulk analysis – a window into cellular heterogeneity. The ability to profile transcriptomic, epigenomic, proteomics, and metabolomics at the single cell level including more recently the spatial information has enhanced our ability to understand interactions between biomolecules in different contexts leading to the discovery of specific cellular subpopulations as well as biological mechanisms underlying pathologies which may be amenable to therapeutic interventions. The scale and availability of a variety of technologies to measure intricate molecular details have provided an impetus to research in many disease areas, including cardiovascular medicine.
Single Cell Omics
DOWNLOAD
Author : Debmalya Barh
language : en
Publisher: Academic Press
Release Date : 2019-07-31
Single Cell Omics written by Debmalya Barh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-31 with Medical categories.
Single-cell Omics, Volume 2: Advances in Applications provides the latest single-cell omics applications in the field of biomedicine. The advent of omics technologies have enabled us to identify the differences between cell types and subpopulations at the level of the genome, proteome, transcriptome, epigenome, and in several other fields of omics. The book is divided into two sections: the first is dedicated to biomedical applications, such as cell diagnostics, non-invasive prenatal testing (NIPT), circulating tumor cells, breast cancer, gliomas, nervous systems and autoimmune disorders, and more. The second focuses on cell omics in plants, discussing micro algal and single cell omics, and more. This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and several members of biomedical field interested in understanding more about single-cell omics and its potential for research and diagnosis.
Vascular And Immuno Metabolism As Drivers Of Cardiovascular Disease Insights Obtained From Omics Approaches
DOWNLOAD
Author : Yvonne Döring
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-11
Vascular And Immuno Metabolism As Drivers Of Cardiovascular Disease Insights Obtained From Omics Approaches written by Yvonne Döring and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-11 with Science categories.
Despite achievements in the management of cardiovascular disease (CVD) over the last 50 years, CVD remains a primary cause of global morbidity and mortality in both emerging and developed economies. Due to the rising aging population in combination with an increase in cardiometabolic risk factors, the number of individuals affected by CVD is currently on the rise. Therefore, it is of utter importance to develop new strategies aimed at reducing CVD risk and elucidate the molecular mechanisms and important players of CVD, including atherosclerosis and plaque rupture and erosion. Over the past years, it became evident that a specific CVD, atherosclerosis, is a multifactorial disease that is not only driven by lipids but also by inflammation. Compelling evidence that inflammation and the immune system play a crucial role in atherosclerotic CVD was provided by the landmark Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), performed in 2017. Here it was shown that a monoclonal antibody targeting interleukin-1b (IL-1b), termed Canakinumab, effectively reduced CVD risk and mortality, especially in patients characterized with residual inflammation. This effect was independent of lipid-level lowering. In late 2019, the inflammation hypothesis of atherosclerosis was confirmed in the Colchicine Cardiovascular Outcomes Trial (COLCOT), using the anti-inflammatory agent colchicine in patients with recent myocardial infarction. A follow-up study in 2020 applying colchicine in a randomized trial involving patients with chronic coronary disease (LoDoCo), also showed significant risk reduction. These landmark studies set the stage for identifying drug targets that block atherosclerosis-specific inflammatory pathways as a highly promising strategy to reduce cardiovascular risk.
Genomic Architecture Of Cardiovascular Diseases
DOWNLOAD
Author : Seitaro Nomura
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-21
Genomic Architecture Of Cardiovascular Diseases written by Seitaro Nomura and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-21 with Medical categories.
Rna Biology In Cardiovascular Disease
DOWNLOAD
Author : Maarten M. G. van den Hoogenhof
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-06
Rna Biology In Cardiovascular Disease written by Maarten M. G. van den Hoogenhof and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-06 with Science categories.
Revolutions In Human Biospecimen Study Leveraging New Technologies To Explore The Pathology Therapeutics And Biomarkers For Atherosclerotic Disease
DOWNLOAD
Author : Ying Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-20
Revolutions In Human Biospecimen Study Leveraging New Technologies To Explore The Pathology Therapeutics And Biomarkers For Atherosclerotic Disease written by Ying Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-20 with Medical categories.
Over the last few years, new high-throughput biotechnologies are revolutionizing our ways to utilize human biospecimens for understanding atherosclerotic disease. These recent advances allow deep profiling of individual cells at the genomics, epigenomics, transcriptomics and proteomics levels, or even simultaneous detection of various combinations of ‘Omics’ in the same cell. Additionally, novel methods to integrate data at different levels from tissue sections and dissociated tissues are the emerging trends in large and institutional biobank studies. Growing literature has shown the value of such sequencing and bioinformatic strategies in shedding light on (1) how risk genes, as identified by the Genome-Wide Association Study, contribute to atherogenesis (genotype to phenotype), and (2) how features of atherosclerotic lesions affect patient response in clinical trials (phenotype to the clinical outcome). The hybrid of cutting-edge biotechnologies and bioinformatic approaches helps us maximize biobank resources to accelerate bench-to-bedside research.
Single Cell Analysis On The Pathophysiology Of Autoimmune Diseases
DOWNLOAD
Author : Shiang-Jong Tzeng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-11
Single Cell Analysis On The Pathophysiology Of Autoimmune Diseases written by Shiang-Jong Tzeng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-11 with Medical categories.
Despite increasing research to facilitate the understanding of the pathophysiology of autoimmune disorders, the exact cause of the incident of autoimmunity is unknown. Current concepts on the occurrence of autoimmune diseases are thought to involve autoantigens, genetic predisposition, disease triggers, and the breakdown of immune tolerance. In addition to the breakdown of immunological tolerance, one key characteristic of autoimmune disease is that within a single disease there is considerable variability in the clinical manifestation and severity in patients. Single-cell omics have emerged as an effective means of unraveling the complexity and heterogeneity of chronic disease development and therapeutic responses. Recently, advances in cutting-edge spatial profiling of diverse cell types have increased our understanding of how distinct cells interact and orchestrate at specific locations across a tissue landscape in both physiological and pathological contexts at the single-cell level.
Artificial Intelligence In Medicine
DOWNLOAD
Author : Lei Xing
language : en
Publisher: Academic Press
Release Date : 2020-09-03
Artificial Intelligence In Medicine written by Lei Xing and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-03 with Medical categories.
Artificial Intelligence Medicine: Technical Basis and Clinical Applications presents a comprehensive overview of the field, ranging from its history and technical foundations, to specific clinical applications and finally to prospects. Artificial Intelligence (AI) is expanding across all domains at a breakneck speed. Medicine, with the availability of large multidimensional datasets, lends itself to strong potential advancement with the appropriate harnessing of AI. The integration of AI can occur throughout the continuum of medicine: from basic laboratory discovery to clinical application and healthcare delivery. Integrating AI within medicine has been met with both excitement and scepticism. By understanding how AI works, and developing an appreciation for both limitations and strengths, clinicians can harness its computational power to streamline workflow and improve patient care. It also provides the opportunity to improve upon research methodologies beyond what is currently available using traditional statistical approaches. On the other hand, computers scientists and data analysts can provide solutions, but often lack easy access to clinical insight that may help focus their efforts. This book provides vital background knowledge to help bring these two groups together, and to engage in more streamlined dialogue to yield productive collaborative solutions in the field of medicine. - Provides history and overview of artificial intelligence, as narrated by pioneers in the field - Discusses broad and deep background and updates on recent advances in both medicine and artificial intelligence that enabled the application of artificial intelligence - Addresses the ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach
Artificial Intelligence In Human Health And Diseases
DOWNLOAD
Author : Muzafar A. Macha
language : en
Publisher: Springer Nature
Release Date : 2025-07-17
Artificial Intelligence In Human Health And Diseases written by Muzafar A. Macha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-17 with Medical categories.
This book discusses current concepts and future translational possibilities of Artificial Intelligence (AI) in human healthcare and diseases. The initial chapter reviews the application and integration of AI and multi-omics to develop novel diagnostic and therapeutic strategies. The book chapter also explores the recent advances in data-driven approaches that aided state-of-the-art AI for biomarker discovery and better disease diagnosis. The book also offers computational and oncological prospects for the role of AI in radio genomics, as well as its offers, achievements, opportunities, and limitations in the current clinical practices. The chapters further cover the role of the current state of AI in Cardiovascular Disease, Obesity and Diabetes, Neurological Diseases, and Infectious Diseases. Towards the end, the book highlights the use of AI in diverse pharmaceutical industry sectors, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. This book is handy for basic, translational, clinical & interdisciplinary researchers and bioinformaticians.
Revolutionizing Immunological Disease Understanding Through Single Cell Multi Omics Technologies
DOWNLOAD
Author : Jennie R. Lill
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-17
Revolutionizing Immunological Disease Understanding Through Single Cell Multi Omics Technologies written by Jennie R. Lill and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-17 with Medical categories.
Single cell technologies, encompassing genomics and proteomics, are at the forefront of revolutionizing our understanding of biological mechanisms at the cellular level, particularly in the context of immunological diseases. These technologies have enabled researchers to dissect complex cellular processes with unprecedented detail, providing crucial spatial context that was previously unattainable. Recent advancements have led to the formulation of new signaling hypotheses and opened novel pathways for therapeutic interventions. The integration of multi-omics approaches, which combine various single cell technologies, has further enhanced our ability to explore intracellular signaling and disease pathology. Despite these advancements, challenges remain in optimizing data interpretation and understanding the full scope of these technologies' impact on immunological and cancer immunological disease pathogenesis. There is a pressing need for continued exploration and refinement of these methodologies to fully harness their potential in elucidating disease mechanisms.