Skeletal And Genetic Determinants Of Osteoporosis
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Skeletal And Genetic Determinants Of Osteoporosis
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Author : Angelique Elisabeth Adriana Maria Weel
language : en
Publisher:
Release Date : 2001
Skeletal And Genetic Determinants Of Osteoporosis written by Angelique Elisabeth Adriana Maria Weel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Genetic Determinants Of Skeletal Growth And Bone Loss
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Author : Yung Van Ho
language : en
Publisher:
Release Date : 1999
Genetic Determinants Of Skeletal Growth And Bone Loss written by Yung Van Ho and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Bones categories.
Genetic Determinants Of Peak Bone Mineral Density
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Author : Brasen
language : en
Publisher:
Release Date : 2010
Genetic Determinants Of Peak Bone Mineral Density written by Brasen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Genetic Determinants Of Bone Mineral Density And Osteoporosis
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Author : John Peter Kemp
language : en
Publisher:
Release Date : 2013
Genetic Determinants Of Bone Mineral Density And Osteoporosis written by John Peter Kemp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Recent Advances In The Genetics Of Osteoporosis
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Author : Jonathan H. Tobias
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-04
Recent Advances In The Genetics Of Osteoporosis written by Jonathan H. Tobias and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Medical categories.
The Genetic And Epigenetic Determinants Of Osteoporosis
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Author : John Morris
language : en
Publisher:
Release Date : 2019
The Genetic And Epigenetic Determinants Of Osteoporosis written by John Morris and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
"Osteoporosis is a common, aging-related disease diagnosed primarily by measuring bone mineral density (BMD). We performed two genome-wide association studies (GWAS) to identify human genetic determinants of BMD estimated from the heel calcaneus (eBMD), leveraging the UK Biobank's interim release (142,487 individuals) and full release (426,824 individuals). We identified a total of 518 (454 novel) genome-wide significant loci, an approximate 7x increase of what was previously known. We also explained up to 20% of its trait variance, with the previous most recent estimate at approximately 6%. We then identified target genes for all loci using a combination of statistical fine-mapping and functional genomics data for SNP annotation. Skeletal phenotyping in mice of novel top candidate genes GPC6, DAAM2, CBX1, DSCC1, RGCC, WAC, and YWHAE confirmed their role in bone biology. We performed further validation of DAAM2 through CRISPR/Cas9 mediated knockouts in a human bone cell line, SaOS-2, and observed a mineralization phenotype for this crucial bone forming cell. Following our GWAS, we performed an epigenome-wide association study (EWAS) to identify human epigenetic determinants of BMD measured at the femoral neck and lumbar spine. We used site-specific CpG DNA methylation assessed in whole blood with the Illumina Infinium HumanMethylation450 array. We studied 4,614 individuals for our discovery analysis but failed to identify any consistently associated findings upon meta-analysis with a validation cohort of 901 individuals. We therefore present the findings in this thesis as novel contributions to the genetic determinants of osteoporosis, and a cautionary tale for the study of the epigenetic determinants of osteoporosis." --
Genetic Determinants Of Peak Bone Mineral Density
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Author : Claus Lohman Brasen
language : en
Publisher:
Release Date : 2010
Genetic Determinants Of Peak Bone Mineral Density written by Claus Lohman Brasen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Genetic Determinants Of Skeletal Diseases
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Author :
language : en
Publisher:
Release Date : 2015
Genetic Determinants Of Skeletal Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Bone Health And Osteoporosis
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Author : United States Public Health Service
language : en
Publisher:
Release Date : 2004-12
Bone Health And Osteoporosis written by United States Public Health Service and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12 with Health & Fitness categories.
This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
The Genetics Of Osteoporosis And Metabolic Bone Disease
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Author : Michael J. Econs
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-05-12
The Genetics Of Osteoporosis And Metabolic Bone Disease written by Michael J. Econs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-12 with Medical categories.
The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to complex disorders, such as osteoporosis, that are not classically thought of as genetic disorders. New insights into the pathogenesis of metabolic bone diseases have been obtained from investigations into the molecular biology of these diseases and new therapies will become available based on these new insights. In The Genefies of Osteoporosis and Metabolie Bane Disease, I have assembled an internationally renowned group of experts to write the various chapters. Each of the authors is an expert in his/her field who is currently performing research on the content of their chapter and have made important contributions to the understanding of the clinical fea tures and pathophysiology of metabolic bone disease and genetics. The first part of The Genefies of Osteoporosis and Metabolie Bane Disease addresses issues related to genetic contributions to the development of osteoporosis and the many factors that must be considered when searching for genesthat predispose to osteoporosis. The second sec tion addresses recent advances in the clinical and molecular biological aspects of inherited metabolic bone disorders. The last section reviews the latest techniques for finding genes that predispose to metabolic bone diseases.