Somatic Stem Cells And Their Plasticity
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Somatic Stem Cells And Their Plasticity
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Author : Albrecht M. Müller
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2002
Somatic Stem Cells And Their Plasticity written by Albrecht M. Müller and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Adaptation (Physiology) categories.
To the scientist, stem cells offer a precious source of undifferentiated material for the study of cell maturation and specialization. To the clinician, these cells represent a potential source of material for the cure and replacement of damaged organs and tissues. They hold great promise for future therapy: Any disease resulting from genetically or environmentally damaged tissues could, in principle, be repaired through a strategic use of stem cells. 'Somatic Stem Cells and Their Plasticity' contains a timely series of review articles which serve as a primer for basic concepts surrounding stem cell biology. A broad range of topics is explored, including a basic definition of 'stem cell-ness', the genetic control of stem cell longevity, transcriptional regulation of stem cell fate and the debate on tissue stem cell plasticity. Aiming to provide a conceptual scaffold of our current knowledge of stem cell biology, this issue highlights areas of current uncertainty and directs interest towards future experimentation. This publication is of interest to anyone who wishes to gain further insights into current aspects of stem cell biology, as well as to people working with stem cells, such as developmental and molecular biologists and hematologists.
Cells Tissues Organs
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Author : Albrecht M. Müller
language : en
Publisher:
Release Date : 2002
Cells Tissues Organs written by Albrecht M. Müller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Stem cells categories.
Adult Stem Cell Therapies Alternatives To Plasticity
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Author : Mariusz Z. Ratajczak
language : en
Publisher: Springer
Release Date : 2014-09-10
Adult Stem Cell Therapies Alternatives To Plasticity written by Mariusz Z. Ratajczak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-10 with Science categories.
This timely volume explores various techniques for tissue and organ regeneration using stem cells isolated from adult tissues. It discusses alternative explanations of stem cell plasticity as well as current clinical results with adult stem cell therapies. It examines the presence of potential pluripotent stem cells in adult tissues, paracrine effects of stem cell therapies, and involvement of exosomes and microparticles into observed phenomena. Fifteen chapters, all written by noted leaders of their fields, focus on a variety of topics including cord blood and hematopoietic stem cells, skin and tissue organ regeneration, very small embryonic-like stem cells, and cell therapies in cardiology, neonatology, and neurology. Edited by Dr. Mariusz Ratajczak, an internationally known specialist in adult stem cell biology, Adult Stem Cell Therapies: Alternatives to Plasticity is an important addition to the Stem Cell Biology and Regenerative Medicine series.
Adult Stem Cells
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Author : Kursad Turksen
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-01-27
Adult Stem Cells written by Kursad Turksen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-27 with Science categories.
Studies on stem cells have been attracting intense scientific and p- lic attention, not only because of controversies surrounding the use of embryonic stem cells but also because of very provocative data that have been emerging on adult stem cells. Much of the public attention and debate has been focused on the possibility that adult stem cells may be used as a substitute for human embryonic stem cells or as a justification for stopping work on them. This has somewhat dim- ished attention on very heated scientific debates that take us to the very heart of how the concept of stem cells is perceived. To this author, the latter debates have not been unlike certain philosophical debates of the last century. Since the seminal studies of Till and McCulloch in the 1960s, the popular paradigm on adult stem cells has been that lineage-restricted stem cells are derived from pluripotent stem cells very early during development. To many, and consistent with much data, the restriction to particular lineages was considered absolute. In other words, there was a sense of determinism in the stem quality of particular stem cells: once they were allocated, they were programmed to specific roles in a given tissue. Furthermore, some adult tissues were considered devoid of detectable stem cell presence or activity.
Somatic Stem Cells
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Author : Shree Ram Singh
language : en
Publisher: Humana Press
Release Date : 2016-08-23
Somatic Stem Cells written by Shree Ram Singh and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
Stem cells are found in almost all organisms from the early stages of development to the end of life. There are several types of stem cells and all of them may prove useful for medical research; however, each of the different types has both promise and limitations. Somatic Stem Cells: Methods and Protocols presents selected genetic, molecular, and cellular techniques used in somatic stem cell research and its clinical application. Chapters focus on the isolation, characterization, purity, plasticity, and clinical uses of somatic stem cells from a variety of human and animal tissues. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Through and intuitive, Somatic Stem Cells: Methods and Protocols seeks to provides scientists with the fundamental techniques of stem cell research and its potential application in regenerative medicine.
Stem Cell Biology
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Author : Jitka Ourednik
language : en
Publisher: Wiley-Blackwell
Release Date : 2005-05-13
Stem Cell Biology written by Jitka Ourednik and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-13 with Science categories.
Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. It is essential that we gain a broader understanding of the factors that regulate the biology of stem cells: their ability for self-renewal, differentiation, and plasticity, as well as the differences between embryonic and adult stem cells. And to learn whether stem cells can be manipulated to replace cells in diseased tissues depends on better understanding their normal developmental properties. This volume offers contributions from numerous interdisciplinary areas bridging biotechnology and biomedical sciences. The ability to isolate and maintain pluripotent stem cells in culture offers exciting possibilities for replacing damaged or diseased organs and tissues. Moreover, stem cells will provide opportunities for major advances in our understanding of fundamental developmental processes. The study of pluripotent stem cells derived from early embryos or fetal tissues has shown that they are capable of replicating indefinitely in vitro and possess the ability to differentiate into many cell types. Biotechnological advances under which growth conditions and factors can be identified and characterized are needed to guide such cells to form organ-specific tissues. Biomedical researchers are also investigating approaches to isolate and manipulate adult-derived multipotential stem cells that appear to possess considerably broader differentiation capacity than originally imagined. Novel therapeutic strategies are being developed to take advantage of the ability of stem cells to proliferate in culture and to survive after transplantation into various tissues, where they may integrate and stably express foreign genes, or repopulate damaged or diseased organs such as the heart, brain, or pancreas. These presentations foster a broader understanding of the factors that regulate the biology and plasticity of stem cells through the picture they provide of the "state of the science" of stem cell biology and by framing the many questions that remain to be answered. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Microenvironment Derived Stem Cell Plasticity
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Author : Jelena Krstic
language : en
Publisher: Frontiers Media SA
Release Date : 2017-12-21
Microenvironment Derived Stem Cell Plasticity written by Jelena Krstic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-21 with Electronic book categories.
Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.
Human Neural Stem Cells
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Author : Leonora Buzanska
language : en
Publisher: Springer
Release Date : 2018-09-12
Human Neural Stem Cells written by Leonora Buzanska and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-12 with Science categories.
This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Stem Cell Biology
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Author : Jitka Ourednick
language : en
Publisher:
Release Date : 2005
Stem Cell Biology written by Jitka Ourednick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. It is essential that we gain a broader understanding of the factors that regulate the biology of stem cells: their ability for self-renewal, differentiation and plasticity, as well as the differences between embryonic and adult stem cells. To gain a better understanding of how and whether stem cells can be manipulated to replace cells in diseased tissues will depend on gaining a better understanding of their normal developmental properties. This volume offers contributions from numerous interdisciplinary areas bridging biotechnology and biomedical sciences. The ability to isolate and maintain pluripotent stem cells in culture offers exciting possibilities for replacing damaged or diseased organs and tissues. Moreover, stem cells will provide opportunities for major advances in our understanding of fundamental developmental processes.
Encyclopedia Of Cancer
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Author : Manfred Schwab
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-23
Encyclopedia Of Cancer written by Manfred Schwab and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-23 with Medical categories.
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.