Statistical Methods For Qtl Mapping
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Statistical Methods For Qtl Mapping
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Author : Zehua Chen
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Statistical Methods For Qtl Mapping written by Zehua Chen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Mathematics categories.
While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping. After introducing basic genetics topics an
Quantitative Trait Loci
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Author : Nicola J. Camp
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Quantitative Trait Loci written by Nicola J. Camp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Medical categories.
In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Statistical Genetics Of Quantitative Traits
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Author : Rongling Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-17
Statistical Genetics Of Quantitative Traits written by Rongling Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-17 with Science categories.
This book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of the DNA-based marker and phenotypic data that arise in agriculture, forestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping, and assumes a background in regression analysis and maximum likelihood approaches. The strength of this book lies in the construction of general models and algorithms for linkage analysis, as well as in QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops.
Statistical Genomics
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Author : Ben Hui Liu
language : en
Publisher: CRC Press
Release Date : 2017-11-22
Statistical Genomics written by Ben Hui Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Mathematics categories.
Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.
A Guide To Qtl Mapping With R Qtl
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Author : Karl W. Broman
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-21
A Guide To Qtl Mapping With R Qtl written by Karl W. Broman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-21 with Science categories.
Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety
Regression Based Methods To Map Quantitative Trait Loci Underlying Function Valued Phenotypes
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Author :
language : en
Publisher:
Release Date : 2014
Regression Based Methods To Map Quantitative Trait Loci Underlying Function Valued Phenotypes written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Most statistical methods for QTL mapping focus on a single phenotype. However, multiple phenotypes are commonly measured, and recent technological advances have greatly simplified the automated acquisition of numerous phenotypes, including function-valued phenotypes, such as growth measured over time. While there exist methods for QTL mapping with function-valued phenotypes, they are generally computationally intensive and focus on single-QTL models. This thesis is composed of two main parts. In the first part, I propose some simple approaches for QTL mapping with function-valued traits, including multiple-QTL models using a penalized likelihood approach. The methods are fast and maintain high power and precision. After identifying multiple QTL by these approaches, we can view the function-valued QTL effects to provide a deeper understanding of the underlying processes. However there are two weaknesses. First, the methods do not work well when the curves are not smooth. Second, they do not take account of the correlation structure among time points. In the second part, I suggest a method to overcome those weaknesses, by smoothing the data set to reduce measurement error, and with functional Principal Component Analysis (PCA). We reduce the functional data into a small number of principal components without much loss of information. We can then proceed with QTL mapping on these dimension-reduced data. We consider four subsequent methods for analysis. First, we simply treat these multiple traits as independent. Second, we use multivariate QTL mapping method proposed by \citet{knott2000}, assuming that the transformed multivariate trait data follow a multivariate normal distribution. The third and fourth ideas are to take the average and maximum of LOD scores for each trait, as considered in the first part. I have implemented these methods in an R package, funqtl (github.com/ikwak2/funqtl ).
Statistical Analysis For Mapping Linked Quantitative Trait Loci
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Author : Jie Xu
language : en
Publisher:
Release Date : 2005
Statistical Analysis For Mapping Linked Quantitative Trait Loci written by Jie Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Principles Of Statistical Genomics
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Author : Shizhong Xu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-13
Principles Of Statistical Genomics written by Shizhong Xu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Science categories.
Statistical genomics is a rapidly developing field, with more and more people involved in this area. However, a lack of synthetic reference books and textbooks in statistical genomics has become a major hurdle on the development of the field. Although many books have been published recently in bioinformatics, most of them emphasize DNA sequence analysis under a deterministic approach. Principles of Statistical Genomics synthesizes the state-of-the-art statistical methodologies (stochastic approaches) applied to genome study. It facilitates understanding of the statistical models and methods behind the major bioinformatics software packages, which will help researchers choose the optimal algorithm to analyze their data and better interpret the results of their analyses. Understanding existing statistical models and algorithms assists researchers to develop improved statistical methods to extract maximum information from their data. Resourceful and easy to use, Principles of Statistical Genomics is a comprehensive reference for researchers and graduate students studying statistical genomics.
Quantitative Trait Loci Analysis In Animals
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Author : Joel Ira Weller
language : en
Publisher: CABI
Release Date : 2009
Quantitative Trait Loci Analysis In Animals written by Joel Ira Weller and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Technology & Engineering categories.
Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.
Quantitative Trait Loci Analysis In Animals
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Author : Joel Ira Weller
language : en
Publisher: CABI
Release Date : 2009
Quantitative Trait Loci Analysis In Animals written by Joel Ira Weller and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This advanced-level textbook covers all the statistical methods that have been used or proposed for detection and analysis of QTL and marker- and gene- assisted selection in animal genetics and breeding, as well as new advances that have revolutionized the field since the first edition.