Stem Cell Plasticity
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Stem Cell Plasticity
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Author : Suraksha Agrawal
language : en
Publisher:
Release Date : 2009
Stem Cell Plasticity written by Suraksha Agrawal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Hematopoietic stem cells categories.
Microenvironment Derived Stem Cell Plasticity
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Author : Jelena Krstic
language : en
Publisher: Frontiers Media SA
Release Date : 2017-12-21
Microenvironment Derived Stem Cell Plasticity written by Jelena Krstic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-21 with Electronic book categories.
Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.
Microenvironment Derived Stem Cell Plasticity
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Author :
language : en
Publisher:
Release Date : 2017
Microenvironment Derived Stem Cell Plasticity written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.
Stem Cell Plasticity
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Author : Suraksha Agrawal
language : en
Publisher: Nova Science Pub Incorporated
Release Date : 2009-01-01
Stem Cell Plasticity written by Suraksha Agrawal and has been published by Nova Science Pub Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Medical categories.
Although hematopoetic stem cell (HSC) transplantation has been in practice for almost half a century, the improved understanding of stem cells over past two decades has revolutionised this field making it as most promising aspect of translational medicine. HSC are found in small numbers in peripheral blood as compared to bone marrow. However, use of growth factors has opened new avenues to successfully use peripheral blood as source of CD 34+ HSC. These are pluripotent cells that are competent for self renewal and differentiation to a variety of specialised cells and are replenished with fresh cells every day. Recent understanding about their mobilisation, homing and plasticity suggest that they can be useful for the maintenance and regeneration of various specialised tissues. This provides an opportunity to explore the specific niche responsible for stem cell plasticity, their trans-differentiation into specific cellular lineages as well the kinetics of their recovery whenever required. The normal physiological microenvironment may be unable to provide a suitable environment for the rapid regeneration of HSC required for coping with tissue damage and may need some external interventions. The autologous stem-cell transplantation (SCT), has decreased risk of graft -- versus -- host disease, and provides opportunities of external interventions in terms of ex vivo manipulation. In the diseases of hematopoietic and immune system allogeneic transplant remains a better modality but is associated with grave risk of graft -- versus -- host disease (GVHD). However, in these cases it is needed to engineer the hematopoietic stem cell (HSC) graft to remove the cells which cause GVHD or relapse to improve graft functions. Hematopoetic stem cell transplantations have been successful in a variety of diseases including leukemia and other hematopoetic disorders. Though results of HSCT are promising, developing a more mechanistic approach to plasticity and improving the external interventions and ex vivo manipulations may lead to improving the efficiency and speed of regeneration of transplanted cells. This could result in better use and wider application of stem cell based therapies.
Adult Stem Cell Therapies Alternatives To Plasticity
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Author : Mariusz Z. Ratajczak
language : en
Publisher: Springer
Release Date : 2014-09-10
Adult Stem Cell Therapies Alternatives To Plasticity written by Mariusz Z. Ratajczak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-10 with Science categories.
This timely volume explores various techniques for tissue and organ regeneration using stem cells isolated from adult tissues. It discusses alternative explanations of stem cell plasticity as well as current clinical results with adult stem cell therapies. It examines the presence of potential pluripotent stem cells in adult tissues, paracrine effects of stem cell therapies, and involvement of exosomes and microparticles into observed phenomena. Fifteen chapters, all written by noted leaders of their fields, focus on a variety of topics including cord blood and hematopoietic stem cells, skin and tissue organ regeneration, very small embryonic-like stem cells, and cell therapies in cardiology, neonatology, and neurology. Edited by Dr. Mariusz Ratajczak, an internationally known specialist in adult stem cell biology, Adult Stem Cell Therapies: Alternatives to Plasticity is an important addition to the Stem Cell Biology and Regenerative Medicine series.
Special Issue On Stem Cell Plasticity
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Author :
language : en
Publisher:
Release Date : 2002
Special Issue On Stem Cell Plasticity written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Somatic Stem Cells And Their Plasticity
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Author : Albrecht M. Müller
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2002
Somatic Stem Cells And Their Plasticity written by Albrecht M. Müller and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Adaptation (Physiology) categories.
To the scientist, stem cells offer a precious source of undifferentiated material for the study of cell maturation and specialization. To the clinician, these cells represent a potential source of material for the cure and replacement of damaged organs and tissues. They hold great promise for future therapy: Any disease resulting from genetically or environmentally damaged tissues could, in principle, be repaired through a strategic use of stem cells. 'Somatic Stem Cells and Their Plasticity' contains a timely series of review articles which serve as a primer for basic concepts surrounding stem cell biology. A broad range of topics is explored, including a basic definition of 'stem cell-ness', the genetic control of stem cell longevity, transcriptional regulation of stem cell fate and the debate on tissue stem cell plasticity. Aiming to provide a conceptual scaffold of our current knowledge of stem cell biology, this issue highlights areas of current uncertainty and directs interest towards future experimentation. This publication is of interest to anyone who wishes to gain further insights into current aspects of stem cell biology, as well as to people working with stem cells, such as developmental and molecular biologists and hematologists.
An Assessment Of Stem Cell Plasticity
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Author : Akiva J. Marcus
language : en
Publisher:
Release Date : 2007
An Assessment Of Stem Cell Plasticity written by Akiva J. Marcus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Encyclopedia Of Cancer
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Author : Manfred Schwab
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-23
Encyclopedia Of Cancer written by Manfred Schwab and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-23 with Medical categories.
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Stem Cell Biology
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Author : Jitka Ourednick
language : en
Publisher:
Release Date : 2005
Stem Cell Biology written by Jitka Ourednick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. It is essential that we gain a broader understanding of the factors that regulate the biology of stem cells: their ability for self-renewal, differentiation and plasticity, as well as the differences between embryonic and adult stem cells. To gain a better understanding of how and whether stem cells can be manipulated to replace cells in diseased tissues will depend on gaining a better understanding of their normal developmental properties. This volume offers contributions from numerous interdisciplinary areas bridging biotechnology and biomedical sciences. The ability to isolate and maintain pluripotent stem cells in culture offers exciting possibilities for replacing damaged or diseased organs and tissues. Moreover, stem cells will provide opportunities for major advances in our understanding of fundamental developmental processes.