Structure Function
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From Protein Structure To Function With Bioinformatics
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Author : Daniel John Rigden
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-11
From Protein Structure To Function With Bioinformatics written by Daniel John Rigden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-11 with Science categories.
Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function.
Viral Membrane Proteins Structure Function And Drug Design
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Author : Wolfgang B. Fischer
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-02
Viral Membrane Proteins Structure Function And Drug Design written by Wolfgang B. Fischer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-02 with Science categories.
In Viral Membrane Proteins: Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and functional knowledge of membrane proteins encoded by viruses. In addition, contributors to the book address questions about proteins as potential drug targets. The range of information covered includes signal proteins, ion channels, and fusion proteins. This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.
Structure Function And Plasticity Of Hippocampal Dentate Gyrus Microcircuits
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Author : Peter Jonas
language : en
Publisher: Frontiers Media SA
Release Date : 2015-02-13
Structure Function And Plasticity Of Hippocampal Dentate Gyrus Microcircuits written by Peter Jonas and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-13 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes. Several lines of evidence suggest that the dentate gyrus acts as a preprocessor of incoming information, preparing it for subsequent processing in CA3. For example, the dentate gyrus converts input from the entorhinal cortex, where cells have multiple spatial fields, into the spatially more specific place cell activity characteristic of the CA3 region. Furthermore, the dentate gyrus is involved in pattern separation, transforming relatively similar input patterns into substantially different output patterns. Finally, the dentate gyrus produces a very sparse coding scheme in which only a very small fraction of neurons are active at any one time. How are these unique functions implemented at the level of cells and synapses? Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. Furthermore, several types of GABAergic interneurons are present in this region, providing inhibitory control over granule cell activity via feedback and feedforward inhibition. Additionally, hilar mossy cells mediate an excitatory loop, receiving powerful input from a small number of granule cells and providing highly distributed excitatory output to a large number of granule cells. Finally, the dentate gyrus is one of the few brain regions exhibiting adult neurogenesis. Thus, new neurons are generated and functionally integrated throughout life. How these specific cellular and synaptic properties contribute to higher brain functions remains unclear. One way to understand these properties of the dentate gyrus is to try to integrate experimental data into models, following the famous Hopfield quote: “Build it, and you understand it.” However, when trying this, one faces two major challenges. First, hard quantitative data about cellular properties, structural connectivity, and functional properties of synapses are lacking. Second, the number of individual neurons and synapses to be represented in the model is huge. For example, the dentate gyrus contains ~1 million granule cells in rodents, and ~10 million in humans. Thus, full scale models will be complex and computationally demanding. In this Frontiers Research Topic, we collect important information about cells, synapses, and microcircuit elements of the dentate gyrus. We have put together a combination of original research articles, review articles, and a methods article. We hope that the collected information will be useful for both experimentalists and modelers. We also hope that the papers will be interesting beyond the small world of “dentology,” i.e., for scientists working on other brain areas. Ideally, the dentate gyrus may serve as a blueprint, helping neuroscientists to define strategies to analyze network organization of other brain regions.
Fat Crystal Networks
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Author : Alejandro G. Marangoni
language : en
Publisher: CRC Press
Release Date : 2004-12-27
Fat Crystal Networks written by Alejandro G. Marangoni and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-27 with Science categories.
The first authoritative source on the subject, this reference discusses the various levels of structure that influence the macroscopic physical properties of fat crystal networks. Fat Crystal Networks summarizes 50 years of structural research in the field, as well as a wealth of information on fat crystal networks pertinent to real-world challenge
Proteins
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Author : David Whitford
language : en
Publisher: John Wiley & Sons
Release Date : 2013-04-25
Proteins written by David Whitford and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-25 with Science categories.
Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
Dna Structure And Function
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Author : Richard R. Sinden
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Dna Structure And Function written by Richard R. Sinden and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics. - Explains basic DNA Structure and function clearly and simply - Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations - Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure - Highlights key experiments and ideas within boxed sections - Illustrated with 150 diagrams and figures that convey structural and experimental concepts
Neural Organization
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Author : Michael A. Arbib
language : en
Publisher: MIT Press
Release Date : 1998
Neural Organization written by Michael A. Arbib and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
In Neural Organization, Arbib, Erdi, and Szentagothai integrate structural, functional, and dynamical approaches to the interaction of brain models and neurobiologcal experiments. Both structure-based "bottom-up" and function- based "top-down" models offer coherent concepts by which to evaluate the experimental data. The goal of this book is to point out the advantages of a multidisciplinary, multistrategied approach to the brain.Part I of Neural Organization provides a detailed introduction to each of the three areas of structure, function, and dynamics. Structure refers to the anatomical aspects of the brain and the relations between different brain regions. Function refers to skills and behaviors, which are explained by means of functional schemas and biologically based neural networks. Dynamics refers to the use of a mathematical framework to analyze the temporal change of neural activities and synaptic connectivities that underlie brain development and plasticity--in terms of both detailed single-cell models and large-scale network models.In part II, the authors show how their systematic approach can be used to analyze specific parts of the nervous system--the olfactory system, hippocampus, thalamus, cerebral cortex, cerebellum, and basal ganglia--as well as to integrate data from the study of brain regions, functional models, and the dynamics of neural networks. In conclusion, they offer a plan for the use of their methods in the development of cognitive neuroscience."
Structure And Function Of The Extracellular Matrix
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Author : Bela Suki
language : en
Publisher: Academic Press
Release Date : 2021-11-27
Structure And Function Of The Extracellular Matrix written by Bela Suki and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-27 with Technology & Engineering categories.
Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki's book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. - Examines the evolutionary origins and consequences of the extracellular matrix - Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system - Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning - Provides an introduction to the properties and organization of the extracellular matrix components
Hydrogenase Structure Function Maturation And Application
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Author : Stefan Frielingsdorf
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-24
Hydrogenase Structure Function Maturation And Application written by Stefan Frielingsdorf and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-24 with Science categories.
Molecular hydrogen (H2) is an important molecule in the metabolism of diverse microorganisms. It is used either as energy source or for the disposal of reducing equivalents depending on environmental conditions. Furthermore, H2 transmits energy between different species within microbial communities. The enzymes that split or evolve H2 are called hydrogenases and these metalloproteins can be divided into three phylogenetically unrelated classes distinguishable by the metal composition of their active sites, namely [Fe]-, [FeFe]-, and [NiFe]- hydrogenases. Following a century of hydrogenase research, it is now possible to isolate, handle, and investigate these fragile enzymes. There have been numerous advances in understanding the regulation, function, structures, and maturation of these enzymes, as well as their involvement in important processes such as microbial pathogenesis and biogeochemical cycling. The employment of hydrogenases and hydrogenase-based applications could also potentially facilitate the world’s transition to a future sustainable H2-based energy economy.
A Manual Of Botany Including The Structure Functions Classification Properties And Uses Of Plants Etc
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Author : Robert Bentley
language : en
Publisher:
Release Date : 1870
A Manual Of Botany Including The Structure Functions Classification Properties And Uses Of Plants Etc written by Robert Bentley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1870 with categories.