Studies Of Regulated Membrane Trafficking

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Studies Of Regulated Membrane Trafficking

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Author : Alona Cohen
language : en
Publisher:
Release Date : 2008

Studies Of Regulated Membrane Trafficking written by Alona Cohen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

Two Studies In Membrane Trafficking

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Author : Holly Christine Dippold
language : en
Publisher:
Release Date : 2009

Two Studies In Membrane Trafficking written by Holly Christine Dippold and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

Eukaryotic cells maintain a complex organization of vesicular transport pathways through which integral membrane proteins and lipids travel. This allows the cell to maintain the proper functional composition of various intracellular membrane-bound compartments and communication with the external environment via the plasma membrane. I have studied two facets of vesicular trafficking. Chapter 1 describes the process of vesicle budding from the Golgi and its relationship to the unique morphology of the Golgi. Chapter 2 discusses the regulation of endocytosis and an attempt to find a target for a ubiquitin-specific protease necessary for endocytosis in yeast. The mechanism underlying the Golgi's flattened structure and its relation to secretory function is an intriguing question in cell biology. Golgi membranes, from yeast to humans, are enriched in phosphatidylinositol-4-phosphate (PtdIns(4)P). In a lipid binding screen, GOLPH3 was identified as a novel PtdIns(4)P-binding protein that depends upon PtdIns(4)P for its Golgi localization. GOLPH3 binds MYO18A, connecting the Golgi to F-actin, thus transmitting a tensile force necessary for Golgi budding and morphology. The same process generating the extended Golgi ribbon observed by fluorescence microscopy and the flattened form observed by electron microscopy drives the formation of transport vesicles. Integral plasma membrane proteins are down-regulated by endocytosis followed by trafficking to the lysosome for degradation. Can1p is a yeast arginine permease at the plasma membrane and undergoes such regulation. Canavanine is a toxic arginine analog that enters the cell through Can1p. A screen of viable yeast deletion mutants to identify genes which when deleted result in hypersensitivity to canavanine was conducted to identify novel components involved in down-regulation and internalization of plasma membrane proteins. Three genes identified were ubiquitin-specific proteases. By visual screening, deletion of UBP3 (UBiquitin-specific Protease 3) was observed to stabilize Can1p-GFP and other endocytic cargoes at the plasma membrane. Rescue experiments show that Ubp3p catalytic activity is necessary for endocytosis. Biochemical experiments indicate that Ubp3p is in a complex with Bre5p, and that Bre5p is also necessary for plasma membrane protein internalization. In conclusion, Ubp3p and its co-factor Bre5p are responsible for deubiquitination and positive regulation of an unidentified protein involved in endocytosis.

Regulatory Mechanisms Of Intracellular Membrane Transport

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Author : Sirkka Keränen
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-27

Regulatory Mechanisms Of Intracellular Membrane Transport written by Sirkka Keränen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-27 with Medical categories.

This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.

Crosstalk And Integration Of Membrane Trafficking Pathways

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Author : Roberto Weigert
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-04-11

Crosstalk And Integration Of Membrane Trafficking Pathways written by Roberto Weigert and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-11 with Science categories.

Membrane traffic is a broad field that studies the complex exchange of membranes that occurs inside the cell. Protein, lipids and other molecules traffic among intracellular organelles, and are delivered to, or transported from the cell surface by virtue of membranous carriers generally referred as "transport intermediates". These carriers have different shapes and sizes, and their biogenesis, modality of transport, and delivery to the final destination are regulated by a multitude of very complex molecular machineries. A concept that has clearly emerged in the last decade is that each membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways. The aim of this book is to provide a general overview of the extent of this crosstalk.

Studies Of Constitutive Endocytic Membrane Trafficking And Its Regulation By P13 Kinase

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Author : Jayme L. Martys
language : en
Publisher:
Release Date : 1997

Studies Of Constitutive Endocytic Membrane Trafficking And Its Regulation By P13 Kinase written by Jayme L. Martys and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Trafficking Inside Cells

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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30

Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Connections To Membrane Trafficking Where You Least Expect Them Diseases Dynamics Diet And Distance

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Author : Rachel Susan Kraut
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-28

Connections To Membrane Trafficking Where You Least Expect Them Diseases Dynamics Diet And Distance written by Rachel Susan Kraut and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-28 with categories.

Energy Requirements In Membrane Trafficking

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Author : Carlos M. Guardia
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-07

Energy Requirements In Membrane Trafficking written by Carlos M. Guardia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-07 with Science categories.

Lipid And Protein Regulation Of Membrane Trafficking

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Author : Junyong Jia
language : en
Publisher:
Release Date : 2007

Lipid And Protein Regulation Of Membrane Trafficking written by Junyong Jia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Regulatory Mechanisms Of Intracellular Membrane Transport

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Author : Sirkka Keränen
language : en
Publisher: Springer
Release Date : 2014-10-08

Regulatory Mechanisms Of Intracellular Membrane Transport written by Sirkka Keränen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-08 with Science categories.

This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.