Study On The Cellular Regulation And Function Of Lysine Malonylation Glutarylation And Crotonylation
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Study On The Cellular Regulation And Function Of Lysine Malonylation Glutarylation And Crotonylation
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Author : Xiucong Bao
language : en
Publisher: Springer Nature
Release Date : 2020-03-20
Study On The Cellular Regulation And Function Of Lysine Malonylation Glutarylation And Crotonylation written by Xiucong Bao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-20 with Science categories.
This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases.
Sirtuins In Health And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-02-03
Sirtuins In Health And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-03 with Science categories.
Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research. Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field Provides the latest updates on sirtuins in health and disease
Vibrio Virulence Regulation And Host Interactions
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Author : Lixing Huang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-03
Vibrio Virulence Regulation And Host Interactions written by Lixing Huang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-03 with Science categories.
Mitochondria Hubs Of Cellular Signaling Energetics And Redox Balance
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Author : Miguel A. Aon
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-11
Mitochondria Hubs Of Cellular Signaling Energetics And Redox Balance written by Miguel A. Aon and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-11 with Electronic book categories.
Poised at the convergence of most catabolic and anabolic pathways, mitochondria are the center of heterotrophic aerobic life, representing a hub in the overall metabolic network of cells. The energetic functions performed by mitochondria face the unavoidable redox hurdle of handling huge amounts of oxygen while keeping its own as well as the cellular redox environment under control. Reactive oxygen species (ROS) are produced in the respiratory chain as a result of the energy supplying function of mitochondria. Originally considered an unavoidable by-product of oxidative phosphorylation, ROS have become crucial signaling molecules when their levels are kept within physiological range. This occurs when their production and scavenging are balanced within mitochondria and cells. Mitochondria-generated hydrogen peroxide can act as a signaling molecule within mitochondria or in the cytoplasm, affecting multiple networks that control, for example, cell cycle, stress response, cell migration and adhesion, energy metabolism, redox balance, cell contraction, and ion channels. However, under pathophysiological conditions, excessive ROS levels can happen due to either overproduction, overwhelming of antioxidant defenses, or both. Under oxidative stress, detrimental effects of ROS include oxidation of protein, lipids, and nucleic acids; mitochondrial depolarization and calcium overload; and cell-wide oscillations mediated by ROS-induced ROS release mechanisms. Mitochondrial dysfunction is central in the pathogenesis of numerous human maladies including cardiomyopathies and neurodegeneration. Diseases characterized by altered nutrient metabolism, such as diabetes and cancer, exhibit elevated ROS levels. These may contribute to pathogenesis by increasing DNA mutation, affecting regulatory signaling and transcription, and promoting inflammation. Under metabolic stress, several ionic channels present in the inner and outer mitochondrial membranes can have pro-life and -death effects. In the present E-book, based on the Frontiers Research Topic entitled: "Mitochondria: Hubs of cellular signaling, energetics and redox balance", we address one of the fundamental questions that the field of ROS biology faces today: how do mitochondria accomplish a reliable energy provision and at the same time keep ROS levels within physiological, non-harming, limits but crucial for cellular signaling function? Additionally, and within the perspective of mitochondria as signaling-energetic hubs in the extensive cellular metabolic network, we ask how can their collective dynamics scale from the subcellular to the cellular, tissue and organ levels to affect function in health and disease.
Metabolism And Chromatin Modification In Cancer
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Author : Guillermo Barreto
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-13
Metabolism And Chromatin Modification In Cancer written by Guillermo Barreto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-13 with Science categories.
Lipid Modifications Of Proteins
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Author : Patrick J. Casey
language : en
Publisher: Academic Press
Release Date : 1995-05-16
Lipid Modifications Of Proteins written by Patrick J. Casey and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-05-16 with Nature categories.
This volume is organized around the three major classes of lipids that have been identified in covalent attachment to proteins in eukaryotic cells: isoprenoids, saturated fatty acyl groups and glycosylphosphatidylinositol ( GPI ).
Sirtuins
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Author : Riekelt H. Houtkooper
language : en
Publisher: Springer
Release Date : 2016-11-17
Sirtuins written by Riekelt H. Houtkooper and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-17 with Medical categories.
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.
Waken The Silent Majority Principles And Pathogenic Significance Of Non Acetyl Acylation And Other Understudied Post Translational Modifications
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Author : Yong Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-04
Waken The Silent Majority Principles And Pathogenic Significance Of Non Acetyl Acylation And Other Understudied Post Translational Modifications written by Yong Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-04 with Science categories.
Frontiers In Cardiovascular Medicine Rising Stars 2022
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Author : Liqiu Yan
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-01
Frontiers In Cardiovascular Medicine Rising Stars 2022 written by Liqiu Yan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-01 with Medical categories.
We are delighted to present the inaugural Frontiers in Cardiovascular Medicine “Rising Stars” article collection. This collection showcases the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers were individually nominated by the Chief Editors of the Journal in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of cardiovascular medicine, including the elucidation of fundamental biology, the development of novel diagnostics or therapeutics, computational modelling approaches, and bioengineering strategies for regeneration.
Epigenetic Technological Applications
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Author : Yujun George Zheng
language : en
Publisher: Academic Press
Release Date : 2015-05-30
Epigenetic Technological Applications written by Yujun George Zheng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-30 with Science categories.
Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and application Includes epigenetic applications for state-of-the-art technologies Contains a global perspective on the future of epigenetics