Synthesis Of Functionalized Organoboron Compounds Through Copper I Catalysis
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Synthesis Of Functionalized Organoboron Compounds Through Copper I Catalysis
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Author : Koji Kubota
language : en
Publisher: Springer
Release Date : 2017-06-27
Synthesis Of Functionalized Organoboron Compounds Through Copper I Catalysis written by Koji Kubota and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-27 with Science categories.
This book describes state-of-the-art borylation chemistry using copper(I) catalysis. Enantioselective reactions are included to afford a variety of functionalized, complex organoboronate esters, which will find wide application in asymmetric synthesis, drug discovery, and material science. Organoboron compounds are recognized as useful reagents in organic synthesis; therefore, great effort has been devoted to the development of a simple, mild, and efficient method for their preparation in the past several years. However, the synthesis of functionalized organoboron compounds remains a challenging issue because known reactions often require the use of highly reactive organometallic carbon nucleophiles. This book focuses on conceptually new, formal nucleophilic copper(I)-catalyzed borylation reactions with diboron compounds that show high selectivity and excellent functional group compatibility. Theoretical studies based on density functional theory calculations to understand the reaction mechanisms have also been described. Advances in this novel borylation chemistry will allow the rapid and efficient synthesis of complex molecules with potentially interesting properties in combination with the boron functionalization process.
Copper I Catalyzed Stereoselective Borylation Reactions
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Author : Yu Ozawa
language : en
Publisher: Springer Nature
Release Date : 2023-05-30
Copper I Catalyzed Stereoselective Borylation Reactions written by Yu Ozawa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-30 with Science categories.
This book focuses on the development of novel functionalized organoboron compounds and those synthetic methods. High degrees of chemo-, regio-, and stereoselectivities of the borylation reactions are attained through catalyst design and optimization. Furthermore, the selectivity-determining mechanisms are analyzed with state-of-the-art DFT and other computational methods. In this book, the author synthesizes some multi-substituted alkenyl and allylic boronates via borylation reactions using a copper(I)/diboron catalyst system. Those compounds contain novel densely substituted and distorted structures, which have not been accessed by other methods. The high stereoselectivities are achieved by the optimization of the catalyst, especially the ligand. Some new ligands are also developed in this book. Furthermore, the derivatization of the borylation products is demonstrated to access the sterically demanding complex molecules. Also, the author performs computational analysis to reveal how the catalyst controls the selectivities. The deep insight into the reaction mechanism provides guides for rational catalyst design for not only copper(I) catalysis but also other transition metal catalysis. Thus, the content should be of interest to academic and industrial scientists in a wide range of areas.
Seminars In Organic Synthesis
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Author : Francesco Sannicolò
language : en
Publisher: Royal Society of Chemistry
Release Date : 2003
Seminars In Organic Synthesis written by Francesco Sannicolò and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
The latest volume in this respected series encompasses subjects as diverse as materials with optical or biological properties, chiral molecules, advanced physical methods in organic synthesis and non-classical synthetic methodologies. Critical surveys are presented on: total synthesis of natural products; organometallic compounds in organic synthesis; the introduction and transformation of functional groups; and solid supported synthesis. The accompanying CD-ROM provides pdf files of the articles included in the book. This volume will be an invaluable reference source for students and researchers in both academia and industry.
Practical Functional Group Synthesis
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Author : Robert A. Stockland, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2016-01-26
Practical Functional Group Synthesis written by Robert A. Stockland, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-26 with Science categories.
A practical handbook for chemists performing bond forming reactions, this book features useful information on the synthesis of common functional groups in organic chemistry. • Details modern functional group synthesis through carbon-heteroelement (N, O, P, S, B, halogen) bond forming reactions with a focus on operational simplicity and sustainability. • Summarizes key and recent developments – which are otherwise scattered across journal literature – into a single source • Contains over 100 detailed preparations of common functional groups • Included 25 troubleshooting guides with suggestions and potential solutions to common problems. • Complements the text in enhanced ebook editions with tutorial videos where the author provides an introduction to microwave assisted chemistry
Boron Reagents In Synthesis
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Author : Adiel Coca
language : en
Publisher: ACS Symposium
Release Date : 2018-02-02
Boron Reagents In Synthesis written by Adiel Coca and has been published by ACS Symposium this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-02 with Science categories.
Boron compounds have been used extensively in organic synthesis for more than sixty years. Some of the best known reactions in synthesis, such as the Suzuki-Miyaura cross-coupling and the hydroboration reaction, involve boron compounds. Several natural products containing boron have been isolated in the last fifty years, including ionophoric macrodiolide antibiotics boromycin, borophycin, aplasmomycins A, B, and C, and tartrolons B, C, and E, as well as autoinducer-2. The study of compounds containing boronic acids for application in pharmaceuticals and materials science has grown tremendously over the last few decades. These include bortezomib, ixazomib, and tavaborole. Several more boron-based drugs are currently in clinical trials. Boron neutron capture therapy has the potential to provide a treatment for various cancers. In addition, materials bearing boronic acids are been studied as potential sensors for biological molecules, such as saccharides and glycoproteins that possess cis-1,2- or cis-1,3-diols.
Copper Catalyzed Electrophilic Amination Of Sp2 And Sp3 C H Bonds
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Author : Stacey L. McDonald
language : en
Publisher: Springer
Release Date : 2016-08-18
Copper Catalyzed Electrophilic Amination Of Sp2 And Sp3 C H Bonds written by Stacey L. McDonald and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-18 with Science categories.
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Heterogeneous Catalysis
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Author : K.L. Ameta Ph.D.
language : en
Publisher: CRC Press
Release Date : 2014-09-13
Heterogeneous Catalysis written by K.L. Ameta Ph.D. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-13 with Medical categories.
For more than a century, bioactive heterocycles have formed one of the largest areas of research in organic chemistry. They are important from a biological and industrial point of view as well as to the understanding of life processes and efforts to improve the quality of life. Heterogeneous Catalysis: A Versatile Tool for the Synthesis of Bioactiv
Ideas In Chemistry And Molecular Sciences
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Author : Bruno Pignataro
language : en
Publisher: John Wiley & Sons
Release Date : 2010-04-16
Ideas In Chemistry And Molecular Sciences written by Bruno Pignataro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-16 with Science categories.
Written by some of the most talented young chemists in Europe, this text covers most of the groundbreaking issues in chemistry. It provides an account of the latest research results in European chemistry based on a selection of leading young scientists participating in the 2008 European Young Chemists Award competition. The contributions range from self-organization to new catalytic synthetic methodologies to organocatalysis. In addition, the authors provide a current overview of their field of research and a preview of future directions. For organic, catalytic, natural products and biochemists.
Copper Catalyzed Multi Component Reactions
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Author : Yusuke Ohta
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-20
Copper Catalyzed Multi Component Reactions written by Yusuke Ohta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-20 with Science categories.
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Synthesis And Application Of Organoboron Compounds
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Author : Elena Fernández
language : en
Publisher:
Release Date : 2015
Synthesis And Application Of Organoboron Compounds written by Elena Fernández and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.