Synthetic Gene Circuits
DOWNLOAD
Download Synthetic Gene Circuits PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Synthetic Gene Circuits book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Synthetic Gene Circuits
DOWNLOAD
Author : Filippo Menolascina
language : en
Publisher: Humana
Release Date : 2022-01-21
Synthetic Gene Circuits written by Filippo Menolascina and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-21 with Medical categories.
This volume provides clear and direct protocols to implement automated Design-Build-Test-Learn (DBTL) into synthetic biology research. Chapters detail techniques to model and simulate biological systems, redesign biological systems, setting up of an automated biolaboratory, step-by-step guide on how to perform computer aided design, RNA sequencing, microfluidics -using bacterial cell free extracts, live mammalian cells, computational and experimental procedures, metabolic burden, computational techniques to predict such burden from models, and how DNA parts can be engineered in mammalian cells to sense, and respond to, and intracellular signals in general. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Synthetic Gene Circuits: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Systems Synthetic Biology
DOWNLOAD
Author : Bor-Sen Chen
language : en
Publisher: Nova Science Publishers
Release Date : 2017
Systems Synthetic Biology written by Bor-Sen Chen and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Science categories.
Prof. Chen received the Ph.D degree from the University of Southern California in 1982. He was a professor at National Tsing Hua University and became a distinguished chair professor in 2014. He is a life fellow of IEEE. He has published about 300 journal papers in control, signal processing, communication, systems and synthetic biology. Dr. Hsu received his Ph.D degree form National Tsing Hua University in 2015. Book Description: In this book, the synthetic gene circuits are modeled by nonlinear stochastic systems to consider random genetic variations and random in vivo environmental disturbances. The authors' design purpose is to engineer a robust genetic circuit to achieve a desired behavior or product to tolerate intrinsic random fluctuation and environmental disturbance in the host cell. In this book, the authors first construct several promoter-RBS component libraries according to their regulatory strengths. Then, based on a stochastic system model, they use design biological filters, biological transistor biosensors, genetic lysis circuits, and a genetic transmitter and receiver by selecting adequate promoter-RBS components from their corresponding libraries to meet the prescribed design (user-oriented) specifications through the proposed library-based researching method. These synthetic gene circuits are also implemented by real experiments to confirm their design performance in this book. Based on the purposed synthetic design method, we could achieve these design specifications at one time, saving much trial time by the conventional methods. Therefore, the purposed systematic design methods in this book have many potential applications to more complex gene circuit design of systems synthetic biology in the future.
The Science And Applications Of Synthetic And Systems Biology
DOWNLOAD
Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-12-30
The Science And Applications Of Synthetic And Systems Biology written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-30 with Science categories.
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Introduction To Synthetic Biology
DOWNLOAD
Author : Mario Andrea Marchisio
language : en
Publisher: Springer
Release Date : 2018-05-14
Introduction To Synthetic Biology written by Mario Andrea Marchisio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-14 with Medical categories.
The textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.
Synthetic Genomics
DOWNLOAD
Author : Miguel Fernández-Niño
language : en
Publisher: BoD – Books on Demand
Release Date : 2022-02-02
Synthetic Genomics written by Miguel Fernández-Niño and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-02 with Science categories.
The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field.
Engineering Genetic Circuits
DOWNLOAD
Author : Chris J. Myers
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Engineering Genetic Circuits written by Chris J. Myers and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
This text presents the modeling, analysis, and design methods for systems biology. It discusses how to examine experimental data to learn about mathematical models, develop efficient abstraction and simulation methods to analyze these models, and use analytical methods to design new circuits. The author reviews basic molecular biology and biochemistry principles, covers several methods for modeling and analyzing genetic circuits, and uses phage lambda as an example throughout to help illustrate the methods. He also explores the emerging area of synthetic biology. iBioSim software, lecture slides, and a password-protected solutions manual are available on the author's website.
Engineering Tuneable Gene Circuits In Yeast
DOWNLOAD
Author : Stephen Checkley
language : en
Publisher: GRIN Verlag
Release Date : 2015-09-14
Engineering Tuneable Gene Circuits In Yeast written by Stephen Checkley and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-14 with Science categories.
Doctoral Thesis / Dissertation from the year 2011 in the subject Chemistry - Bio-chemistry, grade: pass, University of Manchester (Manchester Institute of Biotechnology), course: Systems biology doctoral training program -synthetic biology, language: English, abstract: Synthetic biology is an emergent field incorporating aspects of computer science, molecular biology-based methodologies in a systems biology context, taking naturally occurring cellular systems, pathways, and molecules, and selectively engineering them for the generation of novel or beneficial synthetic behaviour. This study described the construction of a novel synthetic gene circuit with interchangeable gene expression components enabling the investigation of tuning circuits for optimal signal to noise ratio. The circuit utilises the inducible downstream transcriptional activation properties of the pheromone-response pathway in the budding yeast Saccharomyces cerevisiae as the basis for initiation.
Genetic Design Automation
DOWNLOAD
Author : Hasan Baig
language : en
Publisher: Springer Nature
Release Date : 2020-09-25
Genetic Design Automation written by Hasan Baig and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-25 with Technology & Engineering categories.
This textbook introduces readers to the recent advances in the emerging field of genetic design automation (GDA). Starting with an introduction and the basic concepts of molecular biology, the authors provide an overview of various genetic design automation tools. The authors then present the DVASim tool (Dynamic Virtual Analyzer and Simulator) which is used for the analysis and verification of genetic logic circuits. This includes methods and algorithms for the timing and threshold value analyses of genetic logic circuits. Next, the book presents the GeneTech tool (A technology mapping tool for genetic circuits) and the methods developed for optimization, synthesis, and technology mapping of genetic circuits. Chapters are followed by exercises which give readers hands-on practice with the tools presented. The concepts and algorithms are thoroughly described, enabling readers to improve the tools or use them as a starting point to develop new tools. Both DVASim and GeneTech are available from the developer’s website, free of charge. This book is intended for a multidisciplinary audience of computer scientists, engineers and biologists. It provides enough background knowledge for computer scientists and engineers, who usually do not have any background in biology but are interested to get involved in this domain. This book not only presents an accessible basic introduction to molecular biology, it also includes software tools which allow users to perform laboratory experiments in a virtual in-silico environment. This helps newbies to get a quick start in understanding and developing genetic design automation tools. The third part of this book is particular useful for biologists who usually find it difficult to grasp programming and are reluctant to developing computer software. They are introduced to the graphical programming language, LabVIEW, from which they can start developing computer programs rapidly. Readers are further provided with small projects which will help them to start developing GDA tools.
Synthetic Biology
DOWNLOAD
Author : Jeffrey Carl Braman
language : en
Publisher: Springer Nature
Release Date :
Synthetic Biology written by Jeffrey Carl Braman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Design And Analysis Of Biomolecular Circuits
DOWNLOAD
Author : Heinz Koeppl
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-21
Design And Analysis Of Biomolecular Circuits written by Heinz Koeppl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-21 with Technology & Engineering categories.
The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.