Targeting Dna Damage Response To Enhance Antitumor Innate Immunity In Radiotherapy
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Targeting Dna Damage Response To Enhance Antitumor Innate Immunity In Radiotherapy
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Author : Qiang Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-08
Targeting Dna Damage Response To Enhance Antitumor Innate Immunity In Radiotherapy written by Qiang Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-08 with Medical categories.
The Dna Damage Response Implications On Cancer Formation And Treatment
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Author : Kum Kum Khanna
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-18
The Dna Damage Response Implications On Cancer Formation And Treatment written by Kum Kum Khanna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Medical categories.
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.
Ionizing Radiation Reprograms Tumor Immune Microenvironment By Inducing Immunogenic Cell Death
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Author : Fei Yu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-25
Ionizing Radiation Reprograms Tumor Immune Microenvironment By Inducing Immunogenic Cell Death written by Fei Yu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-25 with Medical categories.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Dna Repair Machinery In Innate And Adaptive Immunity
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Author : Feilong Meng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-01
Dna Repair Machinery In Innate And Adaptive Immunity written by Feilong Meng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Science categories.
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy
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Author : Patrik Andersson
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Combinatorial Approaches To Enhance Anti Tumor Immunity Focus On Immune Checkpoint Blockade Therapy written by Patrik Andersson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Inflammation And Immunity In Cancer
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Author : Tsukasa Seya
language : en
Publisher: Springer
Release Date : 2015-03-26
Inflammation And Immunity In Cancer written by Tsukasa Seya and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-26 with Medical categories.
This book overviews cancer immunity from broad scientific fields, based on the concept that cancer is a sort of by-product of infection, inflammation, and host immune response. The innate and acquired arms of the immune system mainly participate in tumor immune surveillance, and their activation is critically modulated by the situation of the tumor microenvironment. Many types of immune cells join the formation of the microenvironment. In particular, macrophages and dendritic cells enter the tumor mass to be main players in the inflammatory milieu of tumors. After introducing these topics, the book discusses immunotherapy for cancer patients as an outgrowth of this concept of infection and inflammation. With the contributions of leading scientists actively involved in the field of antitumor immunity study, this book encourages readers to understand the mechanism of general cancers based on inflammation and will facilitate prevention and the development of therapeutics for cancer.
Factors Determining Long Term Anti Tumor Responses To Immune Checkpoint Blockade Therapy
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Author : Alison Taylor
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-31
Factors Determining Long Term Anti Tumor Responses To Immune Checkpoint Blockade Therapy written by Alison Taylor and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-31 with Medical categories.
Immunogenic Cell Death In Cancer From Benchside Research To Bedside
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Author :
language : en
Publisher:
Release Date : 2016
Immunogenic Cell Death In Cancer From Benchside Research To Bedside written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated 'danger signaling' remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and 'danger signaling' has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of "immunogenic cell death" (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.
Exploiting Dna Damage Response In The Era Of Precision Oncology
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Author : Yitzhak Zimmer
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-11
Exploiting Dna Damage Response In The Era Of Precision Oncology written by Yitzhak Zimmer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-11 with Medical categories.
Topic Editor Christian Reinhardt has received funding from companies Gilead, and lecture fees from Abbvie, Merck, and AstraZeneca. All other topic editors declare no competing interests with regards to the Research Topic subject.