Targeting Human Inflammatory Skin Diseases With Natural Products Exploring Potential Mechanisms And Regulatory Pathways
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Targeting Human Inflammatory Skin Diseases With Natural Products Exploring Potential Mechanisms And Regulatory Pathways
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Author : Bey Hing Goh
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-07
Targeting Human Inflammatory Skin Diseases With Natural Products Exploring Potential Mechanisms And Regulatory Pathways written by Bey Hing Goh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-07 with Science categories.
Multi Targeted Natural Products As Cancer Therapeutics Challenges And Opportunities Volume I 2nd Edition
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Author : Jiang-Jiang Qin
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-11
Multi Targeted Natural Products As Cancer Therapeutics Challenges And Opportunities Volume I 2nd Edition written by Jiang-Jiang Qin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-11 with Medical categories.
This Research Topic is part of a series with: Multi-targeted Natural Products as Cancer Therapeutics: Challenges and Opportunities, Volume II Cancer remains a leading cause of disease-related deaths worldwide, despite recent advances in our understanding of cancer initiation, progression, and metastasis. Chemotherapy and radiotherapy have been used as standard non-surgical treatments of human cancer for decades, however, the survival rates of patients with cancer, especially those with advanced diseases are still very low due to the high toxicities of these treatments as well as the severe side effects. This fact has motivated researchers to discover new cancer therapeutics with minimum side effects, which intensively promotes the rapid development of single specific molecule-targeted therapies (SSMTT). Many efforts have been made in world-wide cancer drug discovery research and several single molecule-targeted therapies have been successfully developed. Unfortunately, most of the investments failed because cancer is a genetic disease and always harbors multiple alternations of molecules or genes at the genomic, genetic and epigenetic levels. The inhibition of a single molecule or signaling pathway by SSMTT frequently results in a hyperactive compensation of other cancer-related molecules and signaling pathways as well as the subsequent development of drug resistance. Therefore, identifying multi-targeted therapies, i.e. drugs that are able to target multiple cancer-related genes, proteins, or signaling pathways is a more promising way to success in developing new cancer therapeutics. Natural products, especially those from traditional Chinese medicine and folk remedies in other countries are an extraordinarily important source for new drug discovery over the past decades. Of note, many natural products have often been demonstrated to target several crucial genes or proteins in cancer-related signaling networks and exert synergistic effects. For example, Japonicone A, a dimeric sesquiterpenoid from the medicinal plant Inula japonica, has been found to inhibit tumor growth and metastasis by dually targeting the TNF-α/NF-κB and p53/MDM2 signaling pathways. Traditionally, researchers have believed that the multi-targeting mechanisms of natural products have limited their use in cancer treatment due to the low specificity and potential side effects. The growing interest in developing multi-targeted cancer therapies may provide another golden opportunity to develop natural products as new cancer therapeutics. Nevertheless, critical investigations for a comprehensive understanding of the molecular mechanisms of natural products also mean more challenges. Our long-term goals are to fully understand the molecular targets and mechanisms of action of anticancer natural products and develop them as novel cancer preventive and therapeutic agents. The specific goal of this Research Topic is to bring together the recent findings of newly identified anticancer natural products, especially those with multiple molecular targets. Papers (Original Research articles or Reviews) which discuss the in vitro and in vivo efficacy and pharmacological and toxicological properties of natural products are also welcome to be submitted. Guidelines for the conception and review of submissions As many anticancer drugs working as cytotoxic compounds have non-selective effects annihilating their potential therapeutic benefits, manuscripts are advised to provide evidence of a significant selectivity towards cancer cells (vs. healthy cells). Specifically, if the studied anticancer drug or modality does not target an oncogenic pathway, the authors should make every effort possible to prove that the cytotoxic or cytostatic effects they have identified exhibit selectivity for cancer cells (ideally 1 log difference in EC50 or IC50) vs. non-malignant cells (eg, fibroblasts or primary culture of cells). The authors should also demonstrate the applicability of their anticancer modalities on a minimum of two well-authenticated cancer cell lines (ideally originating from distinct organs/tissues). For manuscripts dealing with plant extracts or other natural substances/compounds, the composition and the stability of the study material must be described in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominating compound(s) are requested. The level of purity must be proven and included. Please refer to the Four Pillars of Best Practice in Ethnopharmacology, a subset of which concerning general standards in natural product research are applied to all such studies in all sections of Frontiers in Pharmacology.
Crosstalk Skin Cells And Immune Cells In Inflammatory Skin Diseases
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Author : Jeong Eun Kim
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-11
Crosstalk Skin Cells And Immune Cells In Inflammatory Skin Diseases written by Jeong Eun Kim and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-11 with Medical categories.
The skin is the human body's largest organ consisting of two layers: epidermis and dermis, and appendages: hair, and sweat glands. The skin not only wraps the body but also protects it from external stimuli and infection, perceives sensations such as pain and itch, and coordinates with various circulating immune cells for immune response/regulation. Recent studies have shown that inflammatory skin diseases, including psoriasis and atopic dermatitis, harbor systemic inflammation/immune abnormalities such as strong Th activation and expansion of specific immune cell subsets. Novel biologics and small molecule inhibitors targeting specific biomarkers and immune signals are much more effective and safer than conventional systemic therapies for these skin diseases.
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis
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Author : Cecilia Battistelli
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-10
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis written by Cecilia Battistelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-10 with categories.
Natural Products For Skin Diseases A Treasure Trove For Dermatologic Therapy
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Author : Heba Abd El-Sattar El-Nashar
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-10-12
Natural Products For Skin Diseases A Treasure Trove For Dermatologic Therapy written by Heba Abd El-Sattar El-Nashar and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Medical categories.
Natural Products for Skin Diseases: A Treasure Trove for Dermatologic Therapy is an enlightening journey through the realm of natural remedies for various skin diseases. The editors have compiled information on effective and holistic treatment approaches that can be applied in clinical settings. This book brings diverse range of topics, including skin protection against harmful radiation, natural remedies for burns and wounds, management of skin pigmentation issues, and herbal treatments for scabies. It also explores the potential of natural cosmetics and their future applications, along with the use of natural products and nanoparticles in skin delivery. All chapters are contributed by experts in dermatology and herbal medicine, and are supplemented with scientific references for advanced readers. The book primarily serves as a textbook for students in medicine and dermatologists in training. It also serves as a valuable guide for dermatologists, researchers, and healthcare professionals, revealing the treasure trove of benefits that natural products offer for treating skin diseases.
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis Volume Ii
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Author : Cecilia Battistelli
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-17
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis Volume Ii written by Cecilia Battistelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-17 with Science categories.
Emerging Talents In Pharmacology Of Anti Cancer Drugs 2022
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Author : Husain Yar Khan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-16
Emerging Talents In Pharmacology Of Anti Cancer Drugs 2022 written by Husain Yar Khan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-16 with Science categories.
New Therapeutic Approaches For Sars Cov 2 Covid 19
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Author : Sergio Cimerman
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-28
New Therapeutic Approaches For Sars Cov 2 Covid 19 written by Sergio Cimerman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-28 with Medical categories.
Genomics Proteomics And Metabolomics In Nutraceuticals And Functional Foods
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Author : Debasis Bagchi
language : en
Publisher: John Wiley & Sons
Release Date : 2015-10-12
Genomics Proteomics And Metabolomics In Nutraceuticals And Functional Foods written by Debasis Bagchi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-12 with Technology & Engineering categories.
Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.
Marine Compounds And Cancer
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Author : Friedemann Honecker
language : en
Publisher: MDPI
Release Date : 2018-06-26
Marine Compounds And Cancer written by Friedemann Honecker and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-26 with Science categories.
This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs