Targeting Neuro Immuno Vascular Interactions In The Brain And The Periphery
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Targeting Neuro Immuno Vascular Interactions In The Brain And The Periphery
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Author : Imola Wilhelm
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-13
Targeting Neuro Immuno Vascular Interactions In The Brain And The Periphery written by Imola Wilhelm and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-13 with Science categories.
Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets
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Author : Xiaoxing Xiong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-10
Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets written by Xiaoxing Xiong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Medical categories.
Neuroscience In The 21st Century
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Author : Donald W. Pfaff
language : en
Publisher: Springer
Release Date : 2016-10-27
Neuroscience In The 21st Century written by Donald W. Pfaff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-27 with Medical categories.
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Cytokines And The Cns
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Author : Richard M. Ransohoff
language : en
Publisher: CRC Press
Release Date : 2005-10-31
Cytokines And The Cns written by Richard M. Ransohoff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-31 with Medical categories.
Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS. As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist’s cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function. Cytokines and the CNS, Second Edition is patterned after the first edition; however, the wealth of knowledge now available adds a tremendous amount of insight and new implications. To guarantee a fresh perspective, the editors made a conscious choice to utilize an entirely new set of contributors, all experts in various aspects of cytokine research. Cytokines and the CNS, Second Edition starts with a chapter on the CNS, focusing on pathological reactions to insult. Next, come three chapters on cytokine biology, followed by four chapters that integrate cytokine biology into basic CNS processes (development; inflammation; immunity; degeneration/repair), after which five chapters apply this body of knowledge to disease or pathology. The book closes with a look at the application of cytokine biology to the treatment of disease, a brand new area of research.
Recent Advances In Psychiatry From Psycho Neuro Immunology Research Autoimmunencephalitis Autoimmune Encephalopathy Mild Encephalitis
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Author : Karl Bechter
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-12
Recent Advances In Psychiatry From Psycho Neuro Immunology Research Autoimmunencephalitis Autoimmune Encephalopathy Mild Encephalitis written by Karl Bechter and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-12 with categories.
Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.
Insect Immunology
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Author : Nancy E. Beckage
language : en
Publisher: Academic Press
Release Date : 2011-04-28
Insect Immunology written by Nancy E. Beckage and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
This work is the first book-length publication on the topic of insect immunology since 1991, complementing earlier works by offering a fresh perspective on current research. Interactions of host immune systems with both parasites and pathogens are presented in detail, as well as the genomics and proteomics, approaches which have been lacking in other publications. Beckage provides comprehensive coverage of topics important to medical researchers, including Drosophila as a model for studying cellular and humoral immune mechanisms, biochemical mediators of immunity, and insect blood cells and their functions. Encompasses the most important topics of insect immunology including mechanisms, genes, proteins, evolution and phylogeny Provides comprehensive coverage of topics important to medical researchers including Drosophila as a model for studying cellular and humoral immune mechanisms, biochemical mediators of immunity, and insect blood cells and their functions Most up-to-date information published with contributions from international leaders in the field
Stroke E Book
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Author : James C. Grotta
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-02-06
Stroke E Book written by James C. Grotta and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-06 with Medical categories.
Authored by the world’s foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You’ll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today’s stroke medicine. Helps you recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Keeps you abreast of the overwhelming volume of studies and guidelines in this dynamic field, providing clear summaries and practical evaluations of all relevant data. Contains updates throughout, including the latest clinical trials (thrombectomy, DAWN, DEFUSE), genetics research, prevention research, new therapies, and the new guidelines from the ASA. Includes new slides for lectures, covering basic science, case studies, and interventional treatment overviews. Features a Key Points summary at the beginning of each chapter so you can quickly find important information. Provides abundant full-color CT images and pathology slides that help you make efficient and accurate diagnoses.
Peripheral Immunity In Parkinson S Disease Emerging Role And Novel Target For Therapeutics
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Author : Cristoforo Comi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-23
Peripheral Immunity In Parkinson S Disease Emerging Role And Novel Target For Therapeutics written by Cristoforo Comi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-23 with categories.
The Blood Brain Barrier Bbb
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Author : Gert Fricker
language : en
Publisher: Springer
Release Date : 2014-10-24
The Blood Brain Barrier Bbb written by Gert Fricker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-24 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Membrane Transporters And Channels As Targets For Drugs
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Author : Graça Soveral
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-03
Membrane Transporters And Channels As Targets For Drugs written by Graça Soveral and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-03 with categories.
Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.