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Targeting The Microenvironment Niche In Hematologic Malignancies


Targeting The Microenvironment Niche In Hematologic Malignancies
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Targeting The Microenvironment Niche In Hematologic Malignancies


Targeting The Microenvironment Niche In Hematologic Malignancies
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Author : Cirino Botta
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-02

Targeting The Microenvironment Niche In Hematologic Malignancies written by Cirino Botta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-02 with Medical categories.




Targeting The Microenvironment Niche In Solid And Hematologic Malignancies Basic And Translational Research


Targeting The Microenvironment Niche In Solid And Hematologic Malignancies Basic And Translational Research
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Author : Cirino Botta
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-28

Targeting The Microenvironment Niche In Solid And Hematologic Malignancies Basic And Translational Research written by Cirino Botta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-28 with Medical categories.




Stem Cells From Hype To Real Hope


Stem Cells From Hype To Real Hope
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Author : Khawaja Husnain Haider
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2018-12-17

Stem Cells From Hype To Real Hope written by Khawaja Husnain Haider and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-17 with Medical categories.


This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.



Linking Cellular Metabolism To Hematological Malignancies Volume Ii


Linking Cellular Metabolism To Hematological Malignancies Volume Ii
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Author : Jian Yu
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-18

Linking Cellular Metabolism To Hematological Malignancies Volume Ii written by Jian Yu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-18 with Medical categories.




Overcoming Physiologic Barriers To Treatments For Hematologic Malignancies By Molecularly Targeting The Tumor Microenvironment


Overcoming Physiologic Barriers To Treatments For Hematologic Malignancies By Molecularly Targeting The Tumor Microenvironment
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Author : Qin Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-29

Overcoming Physiologic Barriers To Treatments For Hematologic Malignancies By Molecularly Targeting The Tumor Microenvironment written by Qin Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-29 with Science categories.


Hematologic malignancies (HMs) represent a group of hematologic cancers originating from bone marrow or lymphoid organs. Currently, leukaemia, lymphoma, and multiple myeloma are the most common HMs. Conventional treatments for HMs include bone marrow transplantation, radiotherapy, chemotherapy, and immunotherapy. Despite the significant achievements obtained over the past decade in the drug therapy of HMs, tumor metastasis and relapse in patients often occurred after an initial response, indicating the generation of drug resistance to current therapies. Moreover, many clinically used therapeutic drugs are often associated with dose-related side effects and a lack of specificity to tumor tissues. The tumor microenvironment (TME) in HMs consists of a complicated network of cellular interactions and signaling cross-talking within the bone marrow cavity, and it plays an essential role in the progression and metastasis of HM. Furthermore, the TME in HMs has formed physiologic barriers such as immunosuppressive microenvironment, upregulated anti-apoptotic system, drug resistance, etc. to facilitate drug resistance and relapse of HMs. It has become widely accepted that effective treatment against HMs may require targeting both the cancer cell and TME.



Hematologic Cancers From Molecular Pathobiology To Targeted Therapeutics


Hematologic Cancers From Molecular Pathobiology To Targeted Therapeutics
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Author : Jianguo Tao
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-13

Hematologic Cancers From Molecular Pathobiology To Targeted Therapeutics written by Jianguo Tao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Medical categories.


In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack and eradicate tumor cells at molecular level and significantly impacted our current therapeutics for hematological malignancies. The recent and ongoing rapid expansion of knowledge in this area has become extensive, dynamic and diffuse over the literature and research publications. This has led to the need to capture and compile the new and current information about hematologic cancer with special emphasis on translation from molecular pathobiology to targeted therapeutics. In this book experts from around the world share their thoughts and knowledge about the pathobiology of hematologic cancer,as well as their view on current treatment approaches and future development in these malignant hematologic diseases. This book is well suited for hematology residents, fellows and hematology-oncology physicians, hematopathologist as well as basic research scientist in the area of hematologic malignancies.



Hematopoietic Stem Cell Niche


Hematopoietic Stem Cell Niche
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-03-10

Hematopoietic Stem Cell Niche written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Science categories.


Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments, such as new data on disease and clinical applications. Specific chapters delve into the evolution of hematopoietic stem cell niches, the role of CNS in the regulation of HSCs, and targeting the bone marrow niche in hematological malignancies. In addition, video content illustrates protocols, transplantation techniques, and work with mice. - Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques - Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice - Each volume concentrates on one organ, making this a unique publication



Rodak S Hematology E Book


Rodak S Hematology E Book
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Author : Elaine M. Keohane
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-02-19

Rodak S Hematology E Book written by Elaine M. Keohane and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-19 with Medical categories.


Featuring hundreds of full-color photomicrographs, Rodak’s Hematology: Clinical Principles and Applications, 5th Edition prepares you for a job in the clinical lab by exploring the essential aspects of hematology. It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This text also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Clinical lab experts Elaine Keohane, Larry Smith, and Jeanine Walenga also cover key topics such as working in a hematology lab, the parts and functions of the cell, and laboratory testing of blood cells and body fluid cells. Instructions for lab procedures include sources of possible errors along with comments. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology instruments are described, compared, and contrasted. UPDATED, full-color illustrations make it easier to visualize hematology concepts and show what you’ll encounter in the lab, with images appearing near their mentions in the text so you don’t have to flip pages back and forth. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW coverage of hematogones in the chapter on pediatric and geriatric hematology helps you identify these cells, a skill that is useful in diagnosing some pediatric leukemias. UPDATED chapter on molecular diagnostics covers new technology and techniques used in the lab.



Hematology Basic Principles And Practice E Book


Hematology Basic Principles And Practice E Book
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Author : Leslie E. Silberstein
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-06-14

Hematology Basic Principles And Practice E Book written by Leslie E. Silberstein and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-14 with Medical categories.


Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas. Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more. Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies. New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.



Leukemia Stem Cells In Hematologic Malignancies


Leukemia Stem Cells In Hematologic Malignancies
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Author : Haojian Zhang
language : en
Publisher: Springer
Release Date : 2019-07-23

Leukemia Stem Cells In Hematologic Malignancies written by Haojian Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-23 with Medical categories.


This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.