Test No 493 Performance Based Test Guideline For Human Recombinant Estrogen Receptor Hrer In Vitro Assays To Detect Chemicals With Er Binding Affinity
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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 493 Performance Based Test Guideline For Human Recombinant Estrogen Receptor Hrer In Vitro Assays To Detect Chemicals With Er Binding Affinity
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2024-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 493 Performance Based Test Guideline For Human Recombinant Estrogen Receptor Hrer In Vitro Assays To Detect Chemicals With Er Binding Affinity written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-25 with categories.
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology for human recombinant in vitro assays to detect substances with estrogen receptor binding affinity (hrER binding assays).
Animal Models In Research
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Author : Harikrishnan Vijayakumar Sreelatha
language : en
Publisher: Springer Nature
Release Date : 2024-04-03
Animal Models In Research written by Harikrishnan Vijayakumar Sreelatha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-03 with Medical categories.
This book describes the development of animal models widely used in biomedical research using step-wise instructions and photographs. Showcasing a wide range of species from zebra fishes, birds, rodents, rabbits, dogs, and pigs, the book includes detailed methodology on how to work with these species and to develop various models. The animal models in neurology including stroke, Alzheimer’s disease, Parkinson’s disease, and Schizophrenia; Animal models in cancer research, sleep disorders, and cardiovascular diseases are described to meet the understanding of researchers who plan to replicate these models in their laboratories. In depth detailing on the development of targeted gene knockouts and transgenics, implantation models that are used in toxicology studies, and pharmacokinetic studies in pigs and dogs are a highlight. Further, the book describes pharmacologic, chemically induced, surgically induced, microbiologically induced, infectious models, models for neurobehavioral studies, oncology research, and pain research. The book has dedicated sections on anesthesia and analgesia and teaches procedures like venous cut-downs and cannulations in pigs and dogs, and endotracheal intubation, mechanical ventilation and thoracotomy in rodents and will serve as a self-training tool. Concepts in the field of animal model development are explained using examples. Sample size selection, study design, and statistical evaluation of experiments involving laboratory animals are explained to enable young researchers to practically understand the nuances. This book will be a valuable tool for academicians, students, scientists, and veterinarians and will benefit equally who are new to the field and who are already working with laboratory animals.
A Handbook Of Environmental Toxicology
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Author : J.P.F. D'Mello
language : en
Publisher: CABI
Release Date : 2019-12-04
A Handbook Of Environmental Toxicology written by J.P.F. D'Mello and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Science categories.
Written by an international team of authors from a range of educational, medical and research establishments, this book is an essential reference for advanced students and researchers in the areas of environmental sciences, ecology, agriculture, environmental health and medicine, in addition to industry and government personnel responsible for environmental regulations and directives. A Handbook of Environmental Toxicology focuses on two key aspects: human disorders and ecotoxicology as affected by major toxins originating from biological sources and pollutants, as well as radiation generated spontaneously or as a result of anthropogenic activity. A diverse array of these potentially harmful agents regularly appear in the atmosphere, soil, water and food, compromising both human health and biodiversity in natural and managed ecosystems.
Adverse Effects Of Engineered Nanomaterials
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Author : Bengt Fadeel
language : en
Publisher: Academic Press
Release Date : 2017-02-14
Adverse Effects Of Engineered Nanomaterials written by Bengt Fadeel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-14 with Medical categories.
Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population. - Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field - Discusses the health implications of experimental data in nanotoxicology - Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters
The History Of Alternative Test Methods In Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-20
The History Of Alternative Test Methods In Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-20 with Medical categories.
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-12-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Science categories.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Reproductive And Developmental Toxicology
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Author : Ramesh C. Gupta
language : en
Publisher: Academic Press
Release Date : 2022-02-11
Reproductive And Developmental Toxicology written by Ramesh C. Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-11 with Medical categories.
**Selected for Doody's Core Titles® 2024 in Toxicology**Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. - Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development - Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis - Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more
Handbook Of Cosmetic Science And Technology
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Author : Frank Dreher
language : en
Publisher: CRC Press
Release Date : 2022-08-11
Handbook Of Cosmetic Science And Technology written by Frank Dreher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-11 with Medical categories.
With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
Ecotoxicology Of Nanoparticles In Aquatic Systems
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Author : Julian Blasco
language : en
Publisher: CRC Press
Release Date : 2019-07-19
Ecotoxicology Of Nanoparticles In Aquatic Systems written by Julian Blasco and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-19 with Science categories.
The use of nanoparticles in medicine, industrial, and other applications has triggered an interest in their potential. This book explores the use of nanoparticles related to their occurrence in the environment, their impact on biota in aquatic systems, application of new methodologies, and changes associated with new global scenarios. The book also covers the bioaccumulation and internalization of nanoparticles as key aspects to assess their uptake and discusses the methodologies for testing ENPs ecotoxicity at different trophic levels.
Test No 493 Performance Based Test Guideline For Human Recombinant Estrogen Receptor Hrer In Vitro Assays To Detect Chemicals With Er Binding Affinity
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Author :
language : en
Publisher:
Release Date : 2015
Test No 493 Performance Based Test Guideline For Human Recombinant Estrogen Receptor Hrer In Vitro Assays To Detect Chemicals With Er Binding Affinity written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.