The Antibody Molecule
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The Antibody Molecule
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Author : Alfred Nisonoff
language : en
Publisher: Academic Press
Release Date : 2014-06-28
The Antibody Molecule written by Alfred Nisonoff and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Nature categories.
The Antibody Molecule reviews the literature leading to current knowledge of the structure of immunoglobulins. The book begins by outlining some of the basic structural characteristics of immunoglobulins without citing the references on which the information is based. Separate chapters follow covering the chemical nature of the active site of an antibody molecule and mechanisms of interaction with hapten; the general structural features and properties of the various classes of human immunoglobulin; and amino acid sequences of human and mouse L chains and of human and rabbit H chains. Subsequent chapters deal with the evolution of the immunoglobulin classes; special properties of mouse, guinea pig, rabbit, and horse immunoglobulins; idiotypic specificities of immunglobulins; and the genetic control of antibodies. This book is meant for immunologists who have not personally observed the development of this exciting period in the history of immunology. It will also provide useful supplemental reading for the serious student or investigator who wishes to become familiar with the nature of the antibody molecule, its genetic control, and mode of action.
The Antibody Molecule
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Author : Anthony R. Rees
language : en
Publisher: Oxford Medical Histories
Release Date : 2015
The Antibody Molecule written by Anthony R. Rees and has been published by Oxford Medical Histories this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
'The Antibody Molecule' is a beautifully illustrated review of the remarkable developments within immunology from the discovery of the antibody molecule to its exploitation in medicine and the scientists and pioneers who were involved. This engaging and authoritative history will appeal to a wide audience
Biochemistry Of Antibodies
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Author : R. Nezlin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biochemistry Of Antibodies written by R. Nezlin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
When the history of immunology in the twentieth century is written, the decade of the 1960's will, in all probability, stand out as the period of greatest advance in the development of molecular immunology. It is appropriate and useful, therefore, that a schol arly and integrated presentation of this progress should be made available in English. The translation of Dr. Nezlin's "Biochem istry of Antibodies" from Russian admirably fulfills this need in the form of a scientific monograph directed to medical and biolog ical scientists. The appearance of this monograph also serves to emphasize the conceptual unification of diverse immunological phenomena which has emerged from progress in molecular immunology. This unity is a consequence of the key role played by the antibody mol ecule (either in solution or cell-bound) in every biological process properly described as immunological. Indeed, immunology as an independent natural science can be described as the study of the structure, interactions, and biosynthes is of the antibody molecule.
The Immunoglobulins
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Author : Roald Nezlin
language : en
Publisher: Academic Press
Release Date : 1998-05-06
The Immunoglobulins written by Roald Nezlin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-06 with Science categories.
This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Describes recent reviews on the structure and function of immunoglobulin molecules of various species Summarizes in detail recent findings on the fine structure of the antigen-combining site Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties Presents extensive references and is lavishly illustrated
The Antibody Enigma
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Author : Thomas Kindt
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Antibody Enigma written by Thomas Kindt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Antibody Enigma is a somewhat personal view of the antibody diversity question from two investigators who have spent the past 18 years trying to penetrate the enigma. It is not and was not meant to be an all-embracing comprehensively referenced review of the subject of antibody diversity. Because of the subjective viewpoint, there are un doubtedly omissions of data that others consider to be seminal, and if we have offended anyone by omitting their own contribution we sin cerelyapologize. We have lived with "The Enigma" on and off for the past two years. It has been both hard work and good fun but, above all, it has been a learning experience. There were several difficult decisions to make in putting together the final text, but perhaps the most difficult was de ciding upon a stopping point. The field of antibody diversity is presently enjoying an unparalleled expansion of information, and because of this it was very tempting to await further developments in hopes of tying up as many loose ends as possible. This was decided against for several reasons; the major factor was that the project was growing burdensome for both of us. From a more objective point of view this appears to be a reasonable time to stop our exposition.
Antibodies
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Author : A. Szentivanyi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Antibodies written by A. Szentivanyi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
This publication is based on a Symposium that has been held in Clearwater, Florida on February 19-21, 1986, on antibodies, their structure, synthesis, function, and clinical applicability in disease. Organization of this symposium by the University of South Florida College of Medicine was prompted by the unparalleled current expansion of information on these topics in general, and in the field of antibody diver sity, in particular. The issues that surround the last named dimension of this field, began to surface in the late 1950's with the first conclusive genetic studies having been answered, and a new set of concepts has been de fined. As we see it from the material presented in this volume, now new and different questions are being raised and answered by studies in progress, and it may be expected that there will be other questions that will be with us for a considerably longer time. We believe that the symposium brought together many prominent investi gators with different backgrounds and training experiences such as immunolo gists, microbiologists, biochemists, molecular biologists, and clinical sci entists, thus providing an excellent example of the interdisciplinary value of modern immunology and modern biomedical science in general. We believe, therefore, that bringing these complex topics to a wide audience of bio medical scientists through this symposium as well as this volume is of value to the scientific and to the medical community.
The Production Of Antibodies
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Author : Sir Frank Macfarlane Burnet
language : en
Publisher:
Release Date : 1949
The Production Of Antibodies written by Sir Frank Macfarlane Burnet and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1949 with Science categories.
Images Of Biologically Active Structures In The Immune System
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Author : Hilary Koprowski
language : en
Publisher:
Release Date : 1985-08-01
Images Of Biologically Active Structures In The Immune System written by Hilary Koprowski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-08-01 with categories.
Immunoglobulins
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Author : Gary W. Litman
language : en
Publisher: Springer
Release Date : 1978
Immunoglobulins written by Gary W. Litman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Since the discovery more than thirty years ago that antibody actlvlty could be localized to discrete plasma protein fractions, the study of immunoglobulin struc ture and function has dominated the field of immunochemistry. During this time, sources of homogeneous immunoglobulin molecules have been discovered, the subunit nature of the proteins has been defined, and the three-dimensional struc tures of the antigen-recognition portion of several antibody molecules have been elucidated. Insights into the complicated genetic control of these proteins are being gained rapidly through analysis of amino acid sequences of naturally occurring and induced homogeneous immunoglobulins. Immunoglobulins have been analyzed by protein chemists as models of complex multimeric systems, examined by geneticists studying serum protein polymorphisms, and employed by molecular biologists as highly selective probes capable of distinguishing minor features of molecular topog raphy. Clinical applications have ranged from the now routine quantitation of immunoglobulin levels to the use of antibodies to detect trace levels of a variety of natural products and drug metabolites. All these applications have depended ulti mately on a thorough understanding of the immunoglobulin and its antigen-combin ing site. To cover the entire field of immunoglobulin structure and function would require many volumes this size; therefore, subjects presented in this volume represent those which we felt contribute most to our current understanding of this protein family. The first chapters deal with the structure and function of the immunoglobulin molecule.
Antibody Structure And Molecular Immunology
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Author : Federation of European Biochemical Societies
language : en
Publisher:
Release Date : 1975
Antibody Structure And Molecular Immunology written by Federation of European Biochemical Societies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Antigens categories.