The Applied Genomic Epidemiology Handbook

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The Applied Genomic Epidemiology Handbook

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Author : Allison Black
language : en
Publisher: CRC Press
Release Date : 2024-03-18

The Applied Genomic Epidemiology Handbook written by Allison Black and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-18 with Computers categories.

The Applied Genomic Epidemiology Handbook: A Practical Guide to Leveraging Pathogen Genomic Data in Public Health provides rationale, theory, and implementation guidance to help public health practitioners incorporate pathogen genomic data analysis into their investigations. During the SARS-CoV-2 pandemic, viral whole genome sequences were generated, analyzed, and shared at an unprecedented scale. This wealth of data posed both tremendous opportunities and challenges; the data could be used to support varied parts of the public health response but could be hard for much of the public health workforce to analyze and interpret, given a historical lack of experience working with pathogen genomic data. This book addresses that gap. Structured into eight wide-ranging chapters, this book describes how the overlapping timescales of pathogen evolution and infection transmission enable exploration of epidemiologic dynamics from pathogen sequence data. Different approaches to sampling and genomic data inclusion are presented for different types of epidemiologic investigations. To support epidemiologists in diving into pathogen genomic data analysis, this book also introduces the analytic tools and approaches that are readily used in public health departments and presents case studies to show step-by-step how genomic data are used and evaluated in disease investigations. Despite the breadth of scientific literature that uses pathogen genomic data to investigate disease dynamics, there remains little practical guidance to help applied epidemiologists build their ability to explore epidemiologic questions with pathogen genomic data. This handbook was written to serve as that guide. Including case studies, common methods, and software tools, this book will be of great interest to public health microbiologists or lab directors, bioinformaticians, epidemiologists, health officers, academics, as well as students working in a public health context.

Principles Of Computational Genomics

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Author : Paolo Provero
language : en
Publisher: CRC Press
Release Date : 2025-05-13

Principles Of Computational Genomics written by Paolo Provero and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-13 with Science categories.

The advent of high-throughput experimental assays, and in particular of next-generation sequencing, has revolutionized life sciences by enabling the generation of data at the scale of the whole genome. Extracting biologically useful or clinically actionable information from this data requires analytical methods quite different from the ones used to analyze low-throughput experimental results. The development of these methods is the goal of computational biology. Understanding the principles on which these methods are based is thus necessary for all students and researchers in life sciences. This book provides the conceptual framework needed to understand computational genomics enough to be able to follow the arguments in recent papers, or to collaborate with computational scientists in research projects. In particular, it introduces the mathematical and statistical basis of the methods in some depth. The main focus is on the analysis of next-generation-sequencing assays, both for the interpretation of the DNA sequence per se (sequence alignment, phylogenetic tree reconstruction, genetic variants) and for the study of gene regulation and epigenomics (gene expression, transcription factor binding, chromatin states, 3D structure of the genome). The final chapter discusses the associations of genetic variants with phenotypes and diseases, and their biological interpretation. Principles of Computational Genomics provides a solid foundation for understanding the many parts of computational genomics, including those not treated directly in the book. It will be of great benefit to students and researchers across the life sciences.

Systems Biology And Machine Learning Methods In Reproductive Health

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Author : Abhishek Sengupta
language : en
Publisher: CRC Press
Release Date : 2025-01-10

Systems Biology And Machine Learning Methods In Reproductive Health written by Abhishek Sengupta and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-10 with Computers categories.

Systems Biology and Machine Learning Methods in Reproductive Health is an innovative and wide-ranging book that discovers the synergetic combination of disciplines: systems biology and machine learning, with an application in the field of reproductive health. This book assembles the expertise of leading scientists and clinicians to present a compilation of cutting-edge techniques and case studies utilizing computational methods to elucidate intricate biological systems, elucidate reproductive pathways, and address critical issues in the fields of fertility, pregnancy, and reproductive disorders. Bringing science and data science together, this groundbreaking book provides scientists, clinicians, and students with a step-by-step guide to uncovering the complexities of reproductive health through cutting-edge computational tools.

Rna Computational Methods For Structure Kinetics And Rational Design Volume One

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Author : Peter G. Clote
language : en
Publisher: CRC Press
Release Date : 2025-03-20

Rna Computational Methods For Structure Kinetics And Rational Design Volume One written by Peter G. Clote and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Computers categories.

Comprising two volumes, RNA: Computational Methods for Structure, Kinetics, and Rational Design is a comprehensive treatment of computational methods concerning the secondary structure, folding kinetics and rational design of RNA. Volume One concerns energy and structure and is divided into five chapters. Chapter 1 describes the molecular structure of ribonucleotides, basic classes of RNA and databases of RNA sequences and structure. Chapter 2 presents the basic concepts of thermodynamics, since thermodynamics-based algorithms constitute an essential tool in rational design of functional RNA molecules. Chapter 3 describes how empirical secondary structure energy parameters are obtained from ultraviolet absorbance experiments via Van 't Hoff plots and least-squares data fitting. Chapter 4 describes methods from combinatorics, automata and formal language theory, and complex analysis. Chapter 5 provides an overview of some of the most important thermodynamics-based algorithms related to secondary structure. Exercises and solutions are provided at the end of every chapter and source code is available at the book's website (sometimes including computer programs using Python and extensions Numpy and Scipy). This book provides the nuts, bolts and tools to take the next steps in computational RNA synthetic biology. It is perfect for advanced undergraduate, graduate and post-graduate readers having analytical interests and skills from areas such as physical chemistry, physics, mathematics, computer science, and statistics.

Computational Intelligence For Oncology And Neurological Disorders

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Author : Mrutyunjaya Panda
language : en
Publisher: CRC Press
Release Date : 2024-07-15

Computational Intelligence For Oncology And Neurological Disorders written by Mrutyunjaya Panda and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-15 with Computers categories.

With the advent of computational intelligence-based approaches, such as bio-inspired techniques, and the availability of clinical data from various complex experiments, medical consultants, researchers, neurologists, and oncologists, there is huge scope for CI-based applications in medical oncology and neurological disorders. This book focuses on interdisciplinary research in this field, bringing together medical practitioners dealing with neurological disorders and medical oncology along with CI investigators. The book collects high-quality original contributions, containing the latest developments or applications of practical use and value, presenting interdisciplinary research and review articles in the field of intelligent systems for computational oncology and neurological disorders. Drawing from work across computer science, physics, mathematics, medical science, psychology, cognitive science, oncology, and neurobiology among others, it combines theoretical, applied, computational, experimental, and clinical research. It will be of great interest to any neurology or oncology researchers focused on computational approaches.

Handbook Of Statistical Genomics

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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-02

Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-02 with Science categories.

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

The Handbook Of Occupational And Environmental Medicine

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Author : Tee L. Guidotti
language : en
Publisher: Bloomsbury Publishing USA
Release Date : 2020-10-27

The Handbook Of Occupational And Environmental Medicine written by Tee L. Guidotti and has been published by Bloomsbury Publishing USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Medical categories.

Provides health professionals with a single, accessible, and interesting source to prepare for the field of occupational and environmental medicine. The new edition is extensively updated and includes questions for review in preparation for taking exams. This set is designed to be a thorough introduction for physicians entering the occupational and environmental medicine field, whether preparing for specialty examinations or moving into the field from other medical specialties or from primary care. It also serves as a convenient guide and reference for nurses, health professionals, and those outside of health care who need a quick orientation. The set is written with a strong and coherent point of view about the value of occupational and environmental medicine and commitment to ethical, worker-centered practice. It is unusual in the depth of its coverage; its inclusion of important topics that are usually overlooked in textbooks of the field, such as risk science; its emphasis on good management of occupational health services; and its thorough integration of material that fits topics together rather than presenting them as if they were separate and unrelated.

Oxford Handbook Of Public Health Practice

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Author : Charles Guest
language : en
Publisher: OUP Oxford
Release Date : 2013-02-28

Oxford Handbook Of Public Health Practice written by Charles Guest and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-28 with Medical categories.

Fully revised and updated for the third edition, the Oxford Handbook of Public Health Practice remains the first resort for all those working in this broad field. Structured to assist with practical tasks, translating evidence into policy, and providing concise summaries and real-world issues from across the globe, this literally provides a world of experience at your fingertips. Easy-to-use, concise and practical, it is structured into seven parts that focus on the vital areas of assessment, data and information, direct action, policy, health-care systems, personal effectiveness and organisational development. Reflecting recent advances, the most promising developments in practical public health are presented, as well as maintaining essential summaries of core disciplines. This handbook is designed to assist students and practitioners around the world, for improved management of disasters, epidemics, health behaviour, acute and chronic disease prevention, community and government action, environmental health, vulnerable populations, and more.

Practical Handbook Of Microbiology

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Author : Lorrence H Green
language : en
Publisher: CRC Press
Release Date : 2021-05-04

Practical Handbook Of Microbiology written by Lorrence H Green and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Science categories.

Practical Handbook of Microbiology, 4th edition provides basic, clear and concise knowledge and practical information about working with microorganisms. Useful to anyone interested in microbes, the book is intended to especially benefit four groups: trained microbiologists working within one specific area of microbiology; people with training in other disciplines, and use microorganisms as a tool or "chemical reagent"; business people evaluating investments in microbiology focused companies; and an emerging group, people in occupations and trades that might have limited training in microbiology, but who require specific practical information. Key Features Provides a comprehensive compendium of basic information on microorganisms—from classical microbiology to genomics. Includes coverage of disease-causing bacteria, bacterial viruses (phage), and the use of phage for treating diseases, and added coverage of extremophiles. Features comprehensive coverage of antimicrobial agents, including chapters on anti-fungals and anti-virals. Covers the Microbiome, gene editing with CRISPR, Parasites, Fungi, and Animal Viruses. Adds numerous chapters especially intended for professionals such as healthcare and industrial professionals, environmental scientists and ecologists, teachers, and businesspeople. Includes comprehensive survey table of Clinical, Commercial, and Research-Model bacteria. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. Chapter 21, "Archaea," of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license available at http://www.taylorfrancis.com See Emanuel Goldman's Open Access article: "Lamarck redux and other false arguments against SARS-CoV-2 vaccination," https://www.embopress.org/doi/full/10.15252/embr.202254675

Handbook Of Statistical Methods For Case Control Studies

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Author : Ørnulf Borgan
language : en
Publisher: CRC Press
Release Date : 2018-06-27

Handbook Of Statistical Methods For Case Control Studies written by Ørnulf Borgan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-27 with Mathematics categories.

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.